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Results of my 6 years of injecting exogenous GDF11

gdf11

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341 replies to this topic

#331 rodentman

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Posted 01 July 2020 - 09:22 PM

this time after trending bad for 24-48hrs (0.05ng injection), rmssd, hrv, diastolic BP, pulse are now trending better than baseline.

 

baseline bp 71, hrv 44, rmssd 17, pulse 80

24hrs after injection diastolic BP 86, hrv 39,rmssd 12, pulse 83

10days after injection injection diastolic BP 73, hrv 48,rmssd 23, pulse 68

 

did anyone experince such trend?shall i try 0.025ng when parameters plateau or start trending bad again?
 

 

For me, it's all over the place, and it's more about trends. The 10 day moving average can sometimes help remove all the noise.

But I honestly don't know if you have to do any sorta 'reload' period after such a long break.  Maybe Steve knows the answer there.



#332 lost69

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Posted 08 July 2020 - 09:52 AM

i had another injection at lower dose 0.025ng 11days later, had worse trends for 3 days and then improvement on all parameters exept diastolic around 75-80.vocal range keeps improving, so i am sure there is repair going on in the end so i ll keep low doses every 10 days and just consider the trends after few days from injection



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#333 rodentman

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Posted 08 July 2020 - 06:25 PM

i had another injection at lower dose 0.025ng 11days later, had worse trends for 3 days and then improvement on all parameters exept diastolic around 75-80.vocal range keeps improving, so i am sure there is repair going on in the end so i ll keep low doses every 10 days and just consider the trends after few days from injection

 

glad to hear your vocal range is improving.  I am also doing doses at about every 10 days or so... but I'm still at a higher dose, about 100pg, but I keep changing things, trying to find the 'sweet spot'.



#334 nickthird

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Posted 18 July 2020 - 08:29 PM

Does this help with vision and myopia?



#335 aribadabar

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Posted 20 July 2020 - 08:05 PM

Does this help with vision and myopia?

No.



#336 QuestforLife

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Posted 12 January 2021 - 09:57 AM

I am starting an LLC to procure peptides and GDF11. Who would want me to order and send out 5ug vials for them from a reputable company? I'm not asking for cash upfront just a commitment to buy it when I get it.

 

Did you go ahead with this? If so, I would be interested.



#337 DJSwarm

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Posted 17 January 2021 - 06:51 PM

Question for the group...

 

Has any one tried this around a run of senolytics, particularly Dasatinib and Quercetin (D + Q), D + Feinstein, or the more accessible Long Pepper + Theaflavin and Feinstein?

 

In my head this looks like a potent 1 2 anti aging punch. Senolytics to remove senescent cells and GDF11 to reactivate stem cell activity and regenerate tissue.

 

I'd be interested in hearing your experience.



#338 Mind

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Posted 18 January 2021 - 01:43 PM

Question for the group...

 

Has any one tried this around a run of senolytics, particularly Dasatinib and Quercetin (D + Q), D + Feinstein, or the more accessible Long Pepper + Theaflavin and Feinstein?

 

In my head this looks like a potent 1 2 anti aging punch. Senolytics to remove senescent cells and GDF11 to reactivate stem cell activity and regenerate tissue.

 

I'd be interested in hearing your experience.

 

Seems like a reasonable n=1 biohacking experiment. I suspect there is some intersection between the people who have taken D+Q (or some other senolytic) and have experimented with GDF-11. Steve Perry might know of a few.



#339 aribadabar

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Posted 18 January 2021 - 07:41 PM

Question for the group...

 

Has any one tried this around a run of senolytics, particularly Dasatinib and Quercetin (D + Q), D + Feinstein, or the more accessible Long Pepper + Theaflavin and Feinstein?

 

In my head this looks like a potent 1 2 anti aging punch. Senolytics to remove senescent cells and GDF11 to reactivate stem cell activity and regenerate tissue.

 

I'd be interested in hearing your experience.

 

I have - you definitely feel D, but Q and F's effects are imperceptible to me.

I have taken GDF11 at 3ng semi-weekly for a few years - I can't say something unmistakable occurred at that dose. A10ng+ however, the GERD/chest heaviness side effect mentioned by Steve is quite pronounced.

 

I am sub 40 so probably that's why I can't report anything profound but still hope it helped somewhat.


Edited by aribadabar, 18 January 2021 - 07:43 PM.


#340 DJSwarm

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Posted 20 January 2021 - 09:50 PM

I have - you definitely feel D, but Q and F's effects are imperceptible to me.

I have taken GDF11 at 3ng semi-weekly for a few years - I can't say something unmistakable occurred at that dose. A10ng+ however, the GERD/chest heaviness side effect mentioned by Steve is quite pronounced.

 

I am sub 40 so probably that's why I can't report anything profound but still hope it helped somewhat.

 

Unfortunately it is looking like GDF11 is mainly helpful for the >50 crowd with the benefit tracking age. You might get better results from BPC-157 for the healing factor and wait until your GDF11 level drops with age a bit. (standard disclaimers) Rocket is also "younger" and didn't notice any improvement but did quickly hit side effects and claims "others" were having the same problem seeing benefits. Eating well and exercise or CR should boost your GDF11 levels without the need for constant injections.

 

If you don't mind, how much D were you taking and what did you feel?

 

Ideally, you shouldn't feel much to anything from a senolytic. Too high a rate of senescent cell removal could possibly end up feeling like the flu from dying cells proinflammatory factors, but I wouldn't expect that high a level of turn over would be good long term as you don't want to overwhelm your repair mechanisms.

 

I'm just about to hit the big 60 and for covid decided to try some runs of long pepper with Finestien for the lock down. I'm going about once every 4 months for about 1 week on.

I tried Trikatu (black pepper, long pepper, ginger) and then "4:1" long pepper extract for about "2 grams" pepper equivalent and have been shooting for 1.2 grams Finestien. Based on some further research I'll probably hold the pepper level as is but increase the Finestien between 1.2 - 3 gr and add fenugreek to further boost bioavailability while doing a shorter 2 day run.

 

The OCD biomarker keepers will hate me for this but the only markers I'm using are how I "feel" and my hair which hasn't been cut since last March. I would say general health and energy are up (over the fall I had to move our family of 5 to a new home and did so without issue) and the effects on my hair were immediately noticeable.  At the start I was pretty gray/white in both hair and beard. After the first run there was a noticeable line as the gray grew out and both darker and browner hair replaced it.  For a while I had noticeably "frosted" tips. The second run I could watch as a visibly dark line in my beard started at the tips of my mouth, traveled down to my jaw and then spread out. It looked like I had drawn in a goatee for a while. Just finished the third run, it takes about a month before anything overtly noticeable shows. I promise to use more biomarkers if I do a run of D. :)

 

I've been seriously considering an off cycle GDF11 run and / or BPC157. GDF11 looks more useful at my age but I admit the injections and dosing are intimidating. BPC157 can be used orally and seems more forgiving but it also looks to be more of a healing factor than a regenerative. Decisions, decisions ...

 

No noticeable problematic side effects so far. I admit liking the intermittent aspect of doing short runs to limit risk and then waiting.

 

According to the latest blood protein research you are just coming off the aging wave that hits from 30-34 (waves hit at 30, 60 and 80). Theoretically, a senescent cell drop should ameliorate that to a degree.  Can you still party like its 2010? AKA, seen any noticeable benefit from the senolytics?



#341 aribadabar

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Posted 20 January 2021 - 11:04 PM

Unfortunately it is looking like GDF11 is mainly helpful for the >50 crowd with the benefit tracking age. You might get better results from BPC-157 for the healing factor and wait until your GDF11 level drops with age a bit. (standard disclaimers) Rocket is also "younger" and didn't notice any improvement but did quickly hit side effects and claims "others" were having the same problem seeing benefits. Eating well and exercise or CR should boost your GDF11 levels without the need for constant injections.

 

If you don't mind, how much D were you taking and what did you feel?

 

Ideally, you shouldn't feel much to anything from a senolytic. Too high a rate of senescent cell removal could possibly end up feeling like the flu from dying cells proinflammatory factors, but I wouldn't expect that high a level of turn over would be good long term as you don't want to overwhelm your repair mechanisms.

 

I'm just about to hit the big 60 and for covid decided to try some runs of long pepper with Finestien for the lock down. I'm going about once every 4 months for about 1 week on.

I tried Trikatu (black pepper, long pepper, ginger) and then "4:1" long pepper extract for about "2 grams" pepper equivalent and have been shooting for 1.2 grams Finestien. Based on some further research I'll probably hold the pepper level as is but increase the Finestien between 1.2 - 3 gr and add fenugreek to further boost bioavailability while doing a shorter 2 day run.

 

The OCD biomarker keepers will hate me for this but the only markers I'm using are how I "feel" and my hair which hasn't been cut since last March. I would say general health and energy are up (over the fall I had to move our family of 5 to a new home and did so without issue) and the effects on my hair were immediately noticeable.  At the start I was pretty gray/white in both hair and beard. After the first run there was a noticeable line as the gray grew out and both darker and browner hair replaced it.  For a while I had noticeably "frosted" tips. The second run I could watch as a visibly dark line in my beard started at the tips of my mouth, traveled down to my jaw and then spread out. It looked like I had drawn in a goatee for a while. Just finished the third run, it takes about a month before anything overtly noticeable shows. I promise to use more biomarkers if I do a run of D. :)

 

I've been seriously considering an off cycle GDF11 run and / or BPC157. GDF11 looks more useful at my age but I admit the injections and dosing are intimidating. BPC157 can be used orally and seems more forgiving but it also looks to be more of a healing factor than a regenerative. Decisions, decisions ...

 

No noticeable problematic side effects so far. I admit liking the intermittent aspect of doing short runs to limit risk and then waiting.

 

According to the latest blood protein research you are just coming off the aging wave that hits from 30-34 (waves hit at 30, 60 and 80). Theoretically, a senescent cell drop should ameliorate that to a degree.  Can you still party like its 2010? AKA, seen any noticeable benefit from the senolytics?

 

75-100mg D for 2 days every quarter. The effects are dose-dependent and consist of pronounced nausea, general weakness and mild flu-like symptoms. You feel "off" most of the day 1.

As to hair hair restoration - no dice I am still prematurely graying but I guess that's due to a genetic reason as that has been the case progressively since my early 20s and D didn't help one iota.

 

I have been using BPC-157 occasionally on at least 5 different cycles but can't report anything noteworthy there either. Maybe mine was bunk , who knows?

I can't pinpoint/ascribe anything to senolytics but then again perhaps my senescent cell burden is minimal ( to nonexistent now, after a few D+Q cycles)

 

Pro tip - you need to add Fisetin to your phone custom/user dictionary as the auto-correct totally killed it at each instance.



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#342 Mind

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Posted 04 May 2021 - 04:23 PM

A recent review of GDF-11 studies, seems somewhat positive: https://www.longecit...gdf11-in-aging/







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