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Mitochondrial theory in cancer, Alzheimer and longevity

mitochondria cancer alzheimer aging

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#1 toto75015

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Posted 07 January 2016 - 04:06 PM


Hi,

 

I've discovered the research of a french physician named Laurent Schwartz on cancer. Unfortunately I found nothing in english on Youtube, only videos in french (for those who can understand french).

 

To summarize his approach:

 

Regarding the research on cancer:

  • he considers that the pharmaceutical industry did no progress on fighting cancer in the last 5 decades, and demonstrate it by statistical analysis showing that we made no progress on the chance to survive on cancer today compared as in the 60's
  • he considers that the hyper specialisation of the research on cancer today is contra-productive,  and we have lost the big picture on the disease

Regarding his view on cancer:

 

  • he considers it's a naturally occuring disease, as a consequence of aging
  • if so, a few and simple adjustments on lifestyle could prevent, slow down or reverse the disease

Regarding his methodology to undertand the disease:

 

  • he set up a team of scientist, not only medical doctors, but mathematicians and physicists, from the prestigious school of engineering Ecole Polytechnique, where he is a teacher.
  • his team performed historical and statistical analysis on all available data, some of these data coming from 19th century
  • his team was focusing on invariants on the different form on cancer, rather than the differences

 

The conclusion they reach:

 

  • the cancer is probably the consequence of mitochondrial malfunction in cell
  • this malfunction can occur from natural aging, or because of external causes like irritations caused by inflamatory or toxic agents
    • for instance he considers that lung cancer as a consequence of smoking, is not related to tar as commonly accepted (low tar cigarettes cause as much cancer has normal tar ones), but because of CO2 and the resulting asphyxiation of mitochondrias in cell
  • boosting mitochondrial function could help against cancer (helping mitochondria with glucose and oxygen)

 

The cure he is testing:

 

  • to slow down the disease, on cancerous patient, he advise to use some simple mitochondrial booster
    • ALA (alpha lipoic acid), intravenously when possible (600mg per day), generally used for diabete
    • hydroxycitrate (3x500 mg per day, beware of impact on your liver
  • for certain patients, he also advise metformin, generally used for diabete, under medical supervision, or naltrexone (reduce glucose uptake on cancer cell) under medical supervision

 

The anecdotal results:

 

  • anecdotally on the patients he followed, some on advanced phase of cancer, he was able to extend their chance of survival, sometimes by many years.

 

Why I found this approach interesting:

 

  • I read this forum for many years now, and here I learned many things regarding the mitochondrial hypothesis on Alzheimer, and why ketogenic diet, or MCT oil can help this disease.
  • I also noticed the threads on C60, and the fact that the rats given C60 not only doubled their lifetime, but also where clean of any tumor at the end of their life.
  • Also the threads on caloric restriction or fasting and its impact on aging and cancer
  • In some of his videos, Laurent Schwartz says that he thinks that neurodegenerative disease are also a consequence of mitochondrial dysfunction.

 

So I think that protecting and boosting our mitochondrias is key to prevent degenerative diseases like cancer, alzheimer etc. and this is why I wanted to share these information with you guys!

 

Any ideas on how to build the ultimate mitochondrial stack?



#2 YimYam

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Posted 08 January 2016 - 11:11 AM

I also would like to build an ultimate mitochondrial stack, for different reasons mind, but we both want to increase mitochondrial function :)

 

PQQ

Forskolin

Oxaloacetate (in the post)

 

First 2 have been very effective for me at helping normalise my out of whack stress response, my latest thread explains that its been discovered that our stress response functionality is very closely related to how well our Mito are functioning. 


Edited by YimYam, 08 January 2016 - 11:13 AM.


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#3 toto75015

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Posted 08 January 2016 - 11:32 AM

Hi,

 

I found only 2 short videos in english of Laurent Schwartz:

 

His view on cancer:

 

 

The metabolic treatment for advanced metastatic cancer:

 



#4 toto75015

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Posted 08 January 2016 - 11:39 AM

Hi YimYam,

 

I never tried PQQ. I will experiment with it.

 

Regarding Forksolin, I used the CILTEP stack for some weeks, but I had to stop because my aggressivity was to the roof. I think that it stimulated too much my thyroid...

 

I will try the forksolin alone to see if I get the same effects.

 

I would also like to try C60oo, anyone has experience with this molecule? Do you feel any effect? Any side effect? How much do you need? Where to source it?



#5 BieraK

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Posted 09 January 2016 - 04:13 AM

c60 or MitoQ

Methylene Blue (Sirt1, SURF1, PGC-1alpha, cytochrome c upregulation, AMPK, Nrf2 Upregulation, enhanced oxygen consumption)

PQQ

Forskolin

ALCAR/ALA

 

 



#6 Logic

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Posted 09 January 2016 - 11:25 AM

The Warburg effect is an important phenomenon characteristic of aging.  It is best known for its existence in cancer cells as well as in aging, and for having several negative biological consequences, though there can be a positive side to it too. The essence of the Warburg effect is a metabolic transformation from energy production  from oxidative phosphorylation in the mitochondria to glycolosis.  The effect was originally seen in cancer cells. ” Warburg’s hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924.[3] He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g. adenosine triphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis). This is in contrast to “healthy” cells which mainly generate energy from oxidative breakdown of pyruvate. Pyruvate is an end-product of glycolysis, and is oxidized within the mitochondria. Hence, according to Warburg, the driver of cancer cells should be interpreted as stemming from a lowering of mitochondrial respiration. Warburg reported a fundamental difference between normal and cancerous cells to be the ratio of glycolysis to respiration; this observation is also known as the Warburg effect(ref).”  Although much of the research literature related to the Warburg effect is cancer-related, in recent years it is being seen to be very important in aging as well.  Specifically, I think there is strong evidence that Warburg metabolism reduces the NAD/NADH ratio in the nucleus, the cytoplasm, and the mitochondria.  And, the Warburg effect may be the main reason why that decline is observed in aging.

http://www.longecity...ion-and-possib/

 

http://www.longecity...cer-treatments/

 

http://www.longecity...-cancer-and-cr/

 

http://www.longecity...ndpost&p=685159

 

http://www.longecity...ndpost&p=708716

 

http://www.longecity...ndpost&p=698270

 



#7 toto75015

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Posted 09 January 2016 - 04:52 PM

Yes the Warburg effect. In a video Schwartz talk about it.

I don't understand why the pharmaceutical industry didn't investigate it better.

So how do we slow down or reverse the Warburg effect?

Do you think that the c60oo experiment of professor Moussa that doubled the lifespan of rats and let them clean of tumor is because of the cancelation of the Warburg effect?

Let's continue to connect the dots.

#8 MG63

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Posted 23 January 2016 - 03:37 AM

Shilajit Resin, Mito-Q (10mg) and PQQ (40MG) great for mitochondria boost



#9 Fred_CALICO

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Posted 11 September 2016 - 11:13 AM

Dr Laurent Schwartz reported on the progress of his research

 



#10 PeaceAndProsperity

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Posted 11 September 2016 - 04:15 PM

This is interesting. He should document his 'curing' of cancer patients if he really did so.

This is amusing though, a wordpress site. Appears he doesn't have an official site. https://biorebus.wor...ge-the-company/



#11 Fred_CALICO

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Posted 11 September 2016 - 07:26 PM

His philosophy is anti-business. He works with state credits. But here in France, research is under very bureaucratic authority of senior officials. Not being in the political line of the bureaucracy, it receives little credit. His research is made of "DIY".
To follow all the same.
 
Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin.
Invest New Drugs. 2012 Jul 14. In press
Schwartz L, Guais A, Israël M, Junod B, Steyaert JM, Crespi E, Baronzio G, Abolhassani M.
 
The French in video provide information about the test treatment. Patient testimonials are also available.
 
 
 


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#12 osris

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Posted 03 January 2020 - 05:48 PM

I periodically (twice a year) drink two teaspoons of sodium bicarbonate in a pint of water twice a day on an empty stomach. This increases oxygen levels in the blood and possibly the cells. 

 

I have had no harmful effects from it: neither high blood pressure nor alkalosis -- as some big pharma sponsored websites warn about.

 

I think there is a thread here somewhere that says it can increase telomere length but I don't think it does. No studies have been done on this as far as I know.

 

I still can't work out if it is a good idea to increase telomere length given that it could theoretically cause cancer. 

 

 







Also tagged with one or more of these keywords: mitochondria, cancer, alzheimer, aging

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