Here is the 1st paragraph
1. Introduction
Resveratrol is an important bioactive constituent of red wine, known for its cardioprotective effects [1]. Over the past two decades, a wide range of scientific evidences obtained from preclinical studies has shown that resveratrol possesses multiple therapeutic effects, including antioxidant, antimicrobial, cardioprotective, anti-tumor, anti-diabetes, anti-obesity and anti-aging effects [2], [3], [4], [5], [6], [7] and [8]. It has also been reported that resveratrol mitigates skin melanoma and other skin diseases [9], [10] and [11]. Although there is a huge body of pre-clinical evidences on therapeutic role of different mechanisms targeted by resveratrol, few of them are confirmed by clinical studies mainly including modulation of different signaling pathways, and also genes expression by its antioxidant and antiinflammatory effects [12], [13] and [14]. During the past decades much attention has also been paid to clinical usages of resveratrol as a cardioprotective agent due to its ability to modulate inflammatory markers and endothelial function, improving of glucose metabolism and also its potent anti-atherogenic effects [15], [16] and [17]. Resveratrol's ability to suppress inflammation and improve mitochondrial function under both in vitro and in vivo conditions is widely publicized [18], [19], [20], [21] and [22].
