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Is neurogenesis and mitochondrial biogenesis good for you?

question neurogenesis mitochondrial biogenesis

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#1 Exception

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Posted 18 February 2016 - 06:26 AM


I've been researching resveratrol a lot recently. I keep reading about how it causes neurogenesis and mitochondrial biogenesis. My question is, are these things necessarily good for you? They intuitively sound good, but I know that intuition can be flawed.



#2 BobbyDick

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Posted 19 February 2016 - 04:28 PM

Deficits are always due to diseases.


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#3 maxwatt

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Posted 22 February 2016 - 10:48 PM

"The dose makes the poison".  In any quantity you are likely to be able to consume, I do not expect these effects to be anything but beneficial.  If you somehow managed to take a few hundred grams all at once, perhaps by gavage, there might be something to worry about.  But even then, I don't think the blood levels attained would be harmful, our ability to absorb resveratrol is limited. 

 

neurogenesis and mitochondrial biogenesis are desirable to keep an aging brain functioning like a young one.


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#4 Exception

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Posted 24 February 2016 - 08:54 PM

I don't doubt you but I must ask how do you know that? Is there some evidence I can look at?



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#5 maxwatt

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Posted 29 February 2016 - 02:30 PM

I don't doubt you but I must ask how do you know that? Is there some evidence I can look at?

 

 
A paper by Boocock et al  studied oral dose escalation and found beyond two grams, no higher blood levels could be attained, and those levels were little higher than a one gram dose.  And the blood levels attained were not that high.  Of more concern than biogenesis might be apoptosis, desireable with defective cells but not usually with healthy cells.  Yet the blood levels attainable by oral dosing do not attain the levels that produce deleterious effects in the many in vitro studies that note horrible effects.    Little to worry about here IMO.

 

Of possible concern to some, there has been reported here cases of muscle and joint pain with high doses, as well as one report of a loss of sense of taste.  The latter I suspect is due to zinc deficiency.  But Muscle and joint pain has not been pinned down as to cofactors, there may be multiple causes.  (Some have resolved with folate supplementation, discussed elsewhere.)  And these affect only a small percentage of users reporting here.  So yes, caution is advised when trying resveratrol or any supplement, gradually increasing dose and stopping or decreasing dose if ill effects are noted, as well as other common-sense precautions, such as adding only one or maybe two things at a time to one's regimen.


Edited by maxwatt, 29 February 2016 - 02:31 PM.

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