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C60 and IGF-1

c60oo

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#1 amw

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Posted 11 April 2016 - 08:46 PM


From what I understand, a decrease in IGF-1 helps the longevity curve by increasing the expression of genes that are involved in oxidative damage. However, there are many aspects of IGF-1 that are beneficial (being more fit, smarter, greater sex drive, etc.). If C60OO is helping our bodies to eliminate oxidative stress, and the polyphenols are also expressing a "hermetic effect" on gene expression, then would it be possible to increase IGF-1 and still attain an increase in life span?



#2 david ellis

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Posted 11 April 2016 - 10:18 PM

I thought that genes controlling oxidative damage become less effective with age.    Do you have some evidence?



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#3 amw

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Posted 12 April 2016 - 12:12 PM

I'm not sure, that's why I'm asking. I believe there's an age related decline in IGF-1, which relates to many physical and neuronal dysfunctions. However, I read that lowering IGF-1 can increase lifespan (mice and centenarians)...so, there's a trade-off. Given the unique properties exhibited thus far of C60OO, I would think that the utilization of these fullerene compounds would enable one to increase IGF-1 without relying on the increased gene expression, afforded by IGF-1 reduction, of genes that are involved in stress reduction. 

 

 



#4 JamesPaul

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Posted 15 November 2018 - 02:45 AM

"hormetic," not "hermetic".  (yes, curse the autocorrect function.)

 

Did you see the post by brosci?  He listed 5 references showing that decreased IGF-1 is not always associated with increased longevity.

 

https://academic.oup...h.ILNE6e6z.dpuf[Both low and high IGF-1 lead to increased mortality.]

https://www.ncbi.nlm...ubmed/14563498/

https://www.ncbi.nlm...les/PMC3348495/

https://www.ncbi.nlm...pubmed/28549705

https://www.ncbi.nlm...pubmed/25787083


Edited by JamesPaul, 15 November 2018 - 02:47 AM.


#5 Rocket

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Posted 23 November 2018 - 02:21 AM

I'm not sure, that's why I'm asking. I believe there's an age related decline in IGF-1, which relates to many physical and neuronal dysfunctions. However, I read that lowering IGF-1 can increase lifespan (mice and centenarians)...so, there's a trade-off. Given the unique properties exhibited thus far of C60OO, I would think that the utilization of these fullerene compounds would enable one to increase IGF-1 without relying on the increased gene expression, afforded by IGF-1 reduction, of genes that are involved in stress reduction.


Lowering IGF-1 occurs for everyone, naturally, and results in multiple deleterious effects on health. There is no benefit to health in having low IGF-1. Lowering it even further than its already minuscule levels doesn't increase life span.

There are populations of people with naturally low IGF-1 whose bodies are never exposed to the levels the rest of the world experiences, and those are the humans that benefit.

After your body is exposed to high levels in adolescence into the 20s, there is no benefit to healthspan or lifespan in knocking out IGF-1. Naturally by 40, IGF-1 is VERY low.

Its no coincidence that as IGF-1 drops, so does the immune system and so do your bones grow weaker and so do your muscles wither.

I don't know what is meant by your comment about c60 and genes making high IGF-1 a healthy option. High IGF-1 like at levels in your late 20s or early 30s isn't unhealthy.

And what does c60 do to genes? I've been in it for about 4 weeks and there are no observed effects othe4 than vivid dreams.





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