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Androgen restores telomeres

androgen danazol telomere

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#1 nowayout

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Posted 19 May 2016 - 02:58 PM


Interesting new article showing that danazol (a mild androgen) treatment can actually lengthen telomeres and improve patients with telomere diseases. 

 

 

N Engl J Med. 2016 May 19;374(20):1922-1931.
Danazol Treatment for Telomere Diseases. Abstract Background Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow failure syndromes. In tissue culture and animal models, sex hormones regulate expression of the telomerase gene. Methods In a phase 1-2 prospective study involving patients with telomere diseases, we administered the synthetic sex hormone danazol orally at a dose of 800 mg per day for a total of 24 months. The goal of treatment was the attenuation of accelerated telomere attrition, and the primary efficacy end point was a 20% reduction in the annual rate of telomere attrition measured at 24 months. The occurrence of toxic effects of treatment was the primary safety end point. Hematologic response to treatment at various time points was the secondary efficacy end point. Results After 27 patients were enrolled, the study was halted early, because telomere attrition was reduced in all 12 patients who could be evaluated for the primary end point; in the intention-to-treat analysis, 12 of 27 patients (44%; 95% confidence interval [CI], 26 to 64) met the primary efficacy end point. Unexpectedly, almost all the patients (11 of 12, 92%) had a gain in telomere length at 24 months as compared with baseline (mean increase, 386 bp [95% CI, 178 to 593]); in exploratory analyses, similar increases were observed at 6 months (16 of 21 patients; mean increase, 175 bp [95% CI, 79 to 271]) and 12 months (16 of 18 patients; mean increase, 360 bp [95% CI, 209 to 512]). Hematologic responses occurred in 19 of 24 patients (79%) who could be evaluated at 3 months and in 10 of 12 patients (83%) who could be evaluated at 24 months. Known adverse effects of danazol - elevated liver-enzyme levels and muscle cramps - of grade 2 or less occurred in 41% and 33% of the patients, respectively. Conclusions In our study, treatment with danazol led to telomere elongation in patients with telomere diseases.

 


Edited by nowayout, 19 May 2016 - 03:00 PM.

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#2 corb

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Posted 19 May 2016 - 05:09 PM

That's an interesting result considering eunuchs supposedly live longer than men with all their parts intact.

Granted I've always questioned the validity of that observation as well so this comes as good news rather than not.



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#3 BasicBiO

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Posted 19 May 2016 - 05:27 PM

Not surprised. I feel considerably younger on TRT...purely subjective, of course, but it works on so many levels that potential telomere restoration is a logical one.







Also tagged with one or more of these keywords: androgen, danazol, telomere

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