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Superoxide Dismutase; superoxide (O2−) radicals (Cancer Role):: NEED INPUT

superoxide dismutase sod cancer cells cellular damage

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#1 birthdaysuit

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Posted 04 August 2016 - 02:22 AM


In the case of an elevated WBC count due to Leukemias and Lymphomas would cancer cells in the blood produce super-oxide (O2-) radicals? 

 

In my understanding Superoxide Dismutases (SOD) eliminates (O2-) and should protect cells from damage induced by free radicals. What I'm trying to get at is in the case of say bacteria, white bloods cells generate reactive oxygen species to KILL bacteria. The smart bacteria will subsequently, produce (SOD) to protect themselves from being eradicated, so does this same principle apply to cancer cells?  

 

There is low SOD production in cancer cells, so couldn't these cancer cells be dependent on SOD? I'm reading plenty of studies that propose the inhibition of SOD to eradicate cancer cells, as the malignant cells are sensitive to SOD's inhibition. So, although it would seem counterproductive to inhibit SOD, it seems that inhibiting it would lead to apoptosis of the cancer cells; it might even be necessary to introduce free-radical-producing agents to aid in this apoptosis. 

 

And in the case of ingesting herbal and supplemental extracts or things like Colostrum, would this have a negative impact on Chemotherapy. I'm hearing that antioxidants can prolong cancer by shielding them and protecting them from chemotherapy agents, could this be said about SOD and its antioxidant profile? 

 


Edited by birthdaysuit, 04 August 2016 - 02:23 AM.


#2 birthdaysuit

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Posted 04 August 2016 - 02:25 AM

I need some help in all of this, I hear that antioxidants should not be taken with Chemotherapy; and producing SOD would be bad for cancer patients?? I'm REALLY CONFUSED



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#3 birthdaysuit

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Posted 04 August 2016 - 02:28 AM

However, this case seems to be different?

 

http://link.springer...A:1006633616629



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#4 birthdaysuit

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Posted 04 August 2016 - 06:25 PM

Any help? I understand elevated superoxide (O2−) radicals would lead to a more susceptible cellular environment for cancer to proliferate, and SOD would help prevent this, however if cancer has in fact proliferated maybe a SOD inhibitor or a targeted free-radical agents could help to inhibit the cancer?


Edited by birthdaysuit, 04 August 2016 - 07:07 PM.






Also tagged with one or more of these keywords: superoxide dismutase, sod, cancer, cells, cellular damage

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