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Effects of sodium selenite on telomerase activity and telomere length

selenium

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#1 PeaceAndProsperity

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Posted 21 October 2016 - 10:29 AM


https://www.ncbi.nlm...pubmed/14673504

 

 

To study the biological basis of selenium in resisting senescence through its effects on cellular telomerase activity and telomere length. In the experiments, the cell line of hepatocytes L-02 was divided into three groups supplemented with sodium selenite at final concentrations of 0, 0.5 and 2.5 micromol/L, respectively. Cellular telomerase activity was measured by telomeric repeat amplification protocol and enzymatic luminometric inorganic pyrophosphate detection assay. RT-PCR was used to semi-quantitatively detect human telomerase reverse transcriptase (hTERT) gene expression. The change of telomere length was assayed through flow cytometry and fluorescence in situ hybridization. Results showed that L-02 cells had low telomerase activity and hTERT gene expression level when cultured in the normal way. The cells grew well after 3-week-cultivation in the media supplemented with 0.5 or 2.5 micromol/L sodium selenite. Besides, sodium selenite significantly increased cellular telomerase activity and hTERT gene expression level. The telomere length of L-02 cells was also extended after 4-week-cultivation with sodium selenite. Thus, sodium selenite at nutritional doses could prolong the life span of hepatocytes L-02 through increasing telomerase activity and telomere length. This result provides a possible mechanism for explaining the anti-senescence function of selenium.

What would be the effective dosage for a human?


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#2 ta5

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Posted 21 October 2016 - 11:15 AM

Would any form of Selenium do this, or is there something special about sodium selenite?


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#3 Believer

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Posted 03 November 2017 - 12:47 AM

If I am reading this correctly then dosages up to 20mg of sodium selenite (0.2mg per kg, so a 100kg person would need 20mg) could be used for treating cancer.

http://www.chelation...e_apoptosis.pdf



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#4 Kentavr

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Posted 25 March 2018 - 07:54 AM

Selenite sodium is a small molecule. This gives 2 logical reasoning:
 
1. Its penetrating ability is much higher than that of cycloastrogenol.
2. A small enough dosage.
 
But ... selenium stimulates cancer
 
Please see the video of the leading gerontologist of Russia Anisimov
 
 
This is a very useful video, I advise everyone to see it!
 
Pro selenium: watch the video on a time interval (36:20 - 36:35):
 
"Selenium causes liver cancer in rats, but there are people who are sensitive to selenium, so this advertising is also not particularly credible."

Edited by Kentavr, 25 March 2018 - 07:55 AM.

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#5 Believer

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Posted 25 March 2018 - 08:37 AM

Please see the video of the leading gerontologist of Russia Anisimov

This is a very useful video, I advise everyone to see it!

Do you expect everyone to understand Russian? There aren't even subtitles. 


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#6 Kentavr

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Posted 25 March 2018 - 06:06 PM

 

Please see the video of the leading gerontologist of Russia Anisimov

This is a very useful video, I advise everyone to see it!

Do you expect everyone to understand Russian? There aren't even subtitles. 

 

 

Yes you are right  :)
I thought you could turn on the subtitles in the settings.
 
Very strange ... Maybe some countries are not interested in this knowledge being disseminated?
 
I translated the effect of selenium to you.
 
Unfortunately, I do not know English well enough to make a quick and accurate translation of the full video

 


Edited by Kentavr, 25 March 2018 - 06:07 PM.

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#7 Jesuisfort

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Posted 29 March 2018 - 07:01 AM

 

 

Please see the video of the leading gerontologist of Russia Anisimov

This is a very useful video, I advise everyone to see it!

Do you expect everyone to understand Russian? There aren't even subtitles. 

 

 

Yes you are right  :)
I thought you could turn on the subtitles in the settings.
 
Very strange ... Maybe some countries are not interested in this knowledge being disseminated?
 
I translated the effect of selenium to you.
 
Unfortunately, I do not know English well enough to make a quick and accurate translation of the full video

 

 

 

Selenium is good for immun system, if you don't eat enough selenium, you can get autoimmune disease,which can increase cancer risk . 


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