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alzheimer drug for reparing teeth

teeth alzheimer drug

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#1 normalizing

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Posted 11 January 2017 - 12:45 AM


i recently found this interesting article; http://www.medicalne...ases/315139.php

 

please guys refer this article to your local dentist and report their response :D


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#2 seivtcho

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Posted 22 January 2017 - 10:22 PM

My response at a first glance

 

The pulp cells, that make the dentin are making it backwards. They lay the dentin in a direction opposite to the careous cavity and reduce the pulp cavity. E.g. they thicken the floor of the with the cost of the pulpal cavity. So at the best you can do with that drug is a pulpal floor. But you will still need to fill the largest part of the cavity.

 

And the most important is the microbes there to be destryed. Because if you dont destroy them and simply seal the cavity, it will make secundary caries and eventually a closed pulp necrosis.



#3 normalizing

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Posted 23 January 2017 - 05:16 AM

 better than root canals. sealing the gap and letting all kinds of mysterious bacteria harbor. it has been shown in studies root canals can harbor such strange bacteria that is so toxic, it can lead to alzheimer and other maladies



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#4 seivtcho

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Posted 23 January 2017 - 09:29 AM

If the existing today procedures for root canal preparation are done, then the microorganisms there shold be killed out.

 

The opposite - if you seal the canal with the microorgaisms inside, then many things can happen. Most often granulomas, root cycts(benignal cysts due to chronic inflammation, not dangerous for the life), but also inflammations with formation of puss. I didnt know about the Alzheimer microorganisms. But even in that case, if you simply leave them there and seal the cavity in the medical logic you should make the matter worse.



#5 Mind_Paralysis

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Posted 23 February 2017 - 01:23 PM

If the existing today procedures for root canal preparation are done, then the microorganisms there shold be killed out.

 

The opposite - if you seal the canal with the microorgaisms inside, then many things can happen. Most often granulomas, root cycts(benignal cysts due to chronic inflammation, not dangerous for the life), but also inflammations with formation of puss. I didnt know about the Alzheimer microorganisms. But even in that case, if you simply leave them there and seal the cavity in the medical logic you should make the matter worse.

 

Hmm, but has there actually BEEN any improvements in root canal preparation in the last decade or so? Is it really better than back in the 70's, (which is the decade I presume the patients afflicted with these imprecisely sanitated root canals come from, so as to be possible to connect the microorganisms to alzheimers)?

 

Perhaps you could explain how things have changed, and why current methods are better?



#6 seivtcho

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Posted 23 February 2017 - 02:27 PM

Things constantly develope. Everything changes - the instruments for prepareing the canals changes, the chemicals with which the canals are treated changes, the canals filling materials change. 

 

If you ask me, the matter is what works, not what when is made. Many teeth with root canals filled in the 70s are still fine. Patients still chew with them. If you take old hand instruments from the 70s, desinfect the canals with a simple natrium hypochlorate and hydrogenic peroxide, do the procedures the correct way and the correct number of times, then seal it with an old-fashioned canal filler (such as Foredent for example) you can get again good results. The same good results you can make with the new technologies. The dentistry has been developed enough good in the 70s to receive the same results as today in terms of treating carieses and root canals.

 

For the Alzheimer and teeth, this is something new - definately after the 70s. Otherwise I should have learned it in the dental school 20 years ago lol.



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#7 xEva

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Posted 24 September 2017 - 03:58 PM

Here is the original article Promotion of natural tooth repair by small molecule GSK3 antagonists

 

abstract:

The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based on calcium or silicon-based mineral aggregates. Such cements remain in the tooth and fail to degrade and thus normal mineral volume is never completely restored. Here we describe a novel, biological approach to dentine restoration that stimulates the natural formation of reparative dentine via the mobilisation of resident stem cells in the tooth pulp. Biodegradable, clinically-approved collagen sponges are used to deliver low doses of small molecule glycogen synthase kinase (GSK-3) antagonists that promote the natural processes of reparative dentine formation to completely restore dentine. Since the carrier sponge is degraded over time, dentine replaces the degraded sponge leading to a complete, effective natural repair. This simple, rapid natural tooth repair process could thus potentially provide a new approach to clinical tooth restoration.

 

regarding Tideglusib:

 

We used a maximum of 21 pg of Tideglusib on the sponges and thus even if 100% of the drug on the sponge is released within a few hours, the maximum systemic concentration, assuming all the drug enters the circulation, would be no more than 21 pg in 1.5 ml. Mouse blood volume is approximately 3000 times smaller than that of a human and thus the mouse dosage in the circulation is equivalent to 63 ng in the human circulation, or 1000 times lower than used in clinical trials. Extrapolating the size of a mouse first molar to that of a human suggests that an equivalent lesion would require around 10 times more reparative dentine formation and thus the anticipated concentrations of Tideglusib required for human tooth repair would be well below that already tested in clinical trials.

 

 

So, all they did was to infuse a biodegradable collagen sponge with minute amount of Tideglusib, left it in cavity (without covering it with glass ionomer cement -? - I did not get this part) and voila, 4-6 weeks later, the sponge was replaced with dentin.

 

Re root canals, there is this "new" 3Mix-MP root canal alternative -- google or see my posts these threads:

http://www.longecity...oot-canals-evil

http://www.longecity...apy-alternative


Edited by xEva, 24 September 2017 - 04:41 PM.

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