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The Obscurity Ladder of Age Reversal Substances

aging substances anti-aging rung ladder

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#1 mrkosh1

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Posted 10 February 2017 - 10:03 AM

I propose that most common, well known, and abundant substances found in food or drink -- which have been continually consumed by large populations of humans -- are the least likely to provide robust reversal of aging mechanisms. Their predicted lack of effectiveness, especially when used in isolation from each other, are due to the simple probability that any powerful anti-aging benefits would have already been observed and documented. Conversely, more obscure natural substances have a greater likelihood of providing meaningful benefits. Simply put, if a substance is only found in minuscule amounts unlikely to induce physiological effects, is only found in a rare plant not normally consumed, localized to a portion of a plant that is normally discarded, typically destroyed in a preparation process, or has only been ingested by isolated, small populations of humans there is a greater chance of a yet undiscovered dramatic anti-aging impact.


The Obscurity Ladder -- Least Obscure and Least Potent vs. Most Obscure and Most Potent


(Please note there will be exceptions to the Ladder.)


Rung Number One


Common whole plants, foods, spices, and herbs. (Example: Turmeric.)


Rung Number Two


Common whole plants, foods, spices, and herbs in unique combination. (Example: Turmeric and Black Pepper.)


Rung Number Three


Abundant specific compounds in common whole plants, foods, spices, and herbs. (Example: Curcumin.)


Rung Number Four


Abundant specific compounds in common whole plants, foods, spices, and herbs in combination. (Example: Curcumin and Piperine.)


Rung Number Five


Rare or sparsely abundant compounds in common whole plants, foods, spices, and herbs; compounds typically destroyed during ordinary preparation or cooking. (Example: Sulforaphane)


Rung Number Six


Rare or sparely abundant compounds in common whole plants, foods, spices, and herbs -- or compounds destroyed during ordinary preparation or cooking -- in combination. (Example: Sulforaphane and Nicotinamide Riboside)


Rung Number Seven


Uncommon or rare whole plants, foods, spices, or herbs. The less researched the better. (Example: A yet to be discovered plant in a tropical rain forest that yields a seed that when eaten dramatically boosts telomerase beyond any available inducer.) For the sake of brevity, I'll place combinations of these rare whole plants here.


Rung Number Eight


Specific isolated compound(s) from rare whole plants, foods, spices, or herbs. (Example: A specific compound in the seed of the yet to be discovered plant in a tropical rain forest that boosts the induction of telomerase to an even higher extent with other potential anti-aging effects as well. Another example could be a plant enzyme that could break apart glucosepane.)


Rung Number Nine


Combinations of these rare specific isolated compounds from either the same or different little known plants that could have highly synergistic effects. (Example: An uber powerful telomerase inducing substance extracted from a tropical seed and a glucosepane dissolving enzyme from a rare arctic fungus that combine to provide additional anti-aging effects or a massively greater overall effect.


Rung Number Ten


Chemically modified specific isolated compound from rare or little known plants to maximize effect to level capable of completely achieving specific end point. (For example: A short period of consuming the compound boosts telomerase production to a level beyond that of Hela cells and elongates telomeres of a centenarian to that of a twenty year old.




Beyond all of the above there are of course artificial xenobiotics or pharmaceuticals that are not found in nature that would require much more regulatory approval to produce, manufacture, distribute, or purchase. Also, for the record, the term "plant" is a stand in for any organism in nature that could confer an anti-aging benefit when applied or consumed, or could contain an anti-aging compound. There could theoretically be a lizard in a rain forest somewhere that secrets a liver enzyme that might have anti-aging potential. Also, the term "compound" could represent many different substances -- a vitamin, a protein, a hormone, an enzyme, an anti-oxidant, a beneficial bacteria, etc.


Now, as we go high up the ladder, there is no guarantee of finding super powerful anti-aging candidates. However, I would say that there is far less chance of finding equivalent candidates while going down the ladder. Fortunately, compounds of varying potency from different rungs of the ladder may be combined with some possible degree of synergy. For example, chamomile as tea (for reducing CD38 which reduces NAD+) which would be on rung number one could be combined with nicotinamide riboside (a NAD+ precursor) which is on rung five (since it is only found only in small quantities in milk).


The purpose of this ladder is to provide a general guideline: the most potent anti-aging breakthroughs from non-xenobiotics will come from rungs six through ten, rather than the first five. There will of course be exceptions, because there are many compounds in well known organisms that have not been thoroughly studied. My guess is that the true low hanging fruit will be found in the form of rarer and less researched substances. Or, perhaps, species of plants/animals/fungus that have yet to be discovered. I think a treasure trove would be any part of the planet with an undocumented eco-system of lifeforms or a truly extraterrestrial environment of biological organisms, such as a sub-surface ocean under Europa's ice or a deep cavern on Mars warmed via geological or chemical processes.


On the more down to Earth and practical side of things for researchers who do not want to research lesser known plants, I'd suggest combinations of compounds like sulforaphane in combination with apigenin, nicotinamide riboside, hydroxytyrosol, astrogaloside, rosmaric acid, or other substances should be tested in-vitro and in-vivo. Conversely, an adventurous biomedical researcher with a large budget could transport a high tech mobile lab and staff to the rain forest and continually analyze substances in little known species immediately after they are being collected. Anti-oxidant potential, induction of anti-aging genes/proteins/pathways (hTERT, NRF2, NQO1, PGC1A, AMPK, SIRT1-7, etc), effects on reversing cellular aging, and toxicity could all be studied -- along with interactions with other compounds.


In conclusion, I'd like to say that if we want to see BIG steps forward in the near future to bring substances with robust anti-aging effects to the general over-the-counter maketplace, we need to look higher on the Obscurity Ladder.

Edited by mrkosh1, 10 February 2017 - 10:22 AM.

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#2 Furniture

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Posted 26 August 2019 - 03:00 AM

Under the assumption that your hypothesis is correct, a chemically modified compound from a common plant could have anti-aging capabilities that are just as potent as a chemically modified compound from a rare plant, if that type of chemical modification is itself rare or nonexistent in nature.

Edited by Furniture, 26 August 2019 - 03:02 AM.

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