11 replies to this topic

[iseethelight]

I recently started taking PS in high doses 1g a day ( yeah expensive shit). It's helping tremendously, mental sharpness has increased, anxiety has and depression has also decreased considerably. I stack it with cod liver oil btw..

 

But I was doing some research on its safety today and found this article. I've seen other things on pubmed saying that serine feeds cancer cells.  The second abstract is pure serine, but PS is just serine with phosphalipids attached.

 

I'm concerned about using PS longterm.

 

I don't quite understand the first abstract, I always struggle with the wording of these researchers. 

 

https://www.ncbi.nlm...pubmed/26915293

 

 

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.

Birge RB1, Boeltz S2, Kumar S1, Carlson J3, Wanderley J4, Calianese D1, Barcinski M5, Brekken RA6,7, Huang X6,7, Hutchins JT3, Freimark B3, Empig C3, Mercer J8, Schroit AJ9, Schett G2, Herrmann M2.

Author information

 

Abstract

Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes have been irreparably damaged. Apoptosis culminates in the rapid and decisive removal of cell corpses by efferocytosis, a term used to distinguish the engulfment of apoptotic cells from other phagocytic processes. Over the past decades, the molecular and cell biological events associated with efferocytosis have been rigorously studied, and many eat-me signals and receptors have been identified. The externalization of phosphatidylserine (PS) is arguably the most emblematic eat-me signal that is in turn bound by a large number of serum proteins and opsonins that facilitate efferocytosis. Under physiological conditions, externalized PS functions as a dominant and evolutionarily conserved immunosuppressive signal that promotes tolerance and prevents local and systemic immune activation. Pathologically, the innate immunosuppressive effect of externalized PS has been hijacked by numerous viruses, microorganisms, and parasites to facilitate infection, and in many cases, establish infection latency. PS is also profoundly dysregulated in the tumor microenvironment and antagonizes the development of tumor immunity. In this review, we discuss the biology of PS with respect to its role as a global immunosuppressive signal and how PS is exploited to drive diverse pathological processes such as infection and cancer. Finally, we outline the rationale that agents targeting PS could have significant value in cancer and infectious disease therapeutics.

 

 

 

Serine and one-carbon metabolism in cancer.

Yang M1, Vousden KH1.

Author information

 

Abstract

The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence. Many cancer cells are highly dependent on serine, a trait that provides several novel therapeutic opportunities, either through the inhibition of de novo serine synthesis or by limiting the availability or uptake of exogenous serine.

PMID:   27634448   DOI:   10.1038/nrc.2016.81

 

[Doc Psychoillogical]

What doesn't cause Cancer one way or another.....

 

[PeaceAndProsperity]

Sounds like it might be increasing dht as it's touted to do. I would love if you could do a blood test to see

[jack black]

Cancer cells are highly dependent on glucose and can't use any other source for energy. Does it make sugar carcinogenic? People, use common sense.

Edited by jack black, 13 March 2017 - 12:27 PM.

[PeaceAndProsperity]

No it doesn't cause cancer, it's a nutrient. Can it exacerbate cancer? Maybe but not likely.

[Duchykins]

Due to the fact that we are living much longer these days, we are giving the late-acting fatal genes we've been accumulating for millions of years a lot more chances to come out and play.  In this manner, cancer has the potential to always win, one way or another.

 

In the case of nutrition, cancer typically needs a combo of factors present all at the same time to be triggered.

 

Now here's the catch - there is a big difference between things that cause cancer and things that feed cancer.  There is also the matter of changes in the body caused by the presence of different kinds of cancer that often confound the results or give readers the wrong idea about what causes or feeds cancer.

[iseethelight]

Fair enough gents. I will continue on with my PS. It does me good.

[AlwaysLearning]

It's true that there's an important distinction to be made between things that cause cancer and things that facilitate its proliferation. However, when you consider that cancerous cells are under normal circumstances generated spontaneously and destroyed by the immune system without causing the disease we refer to as cancer, the distinction becomes somewhat blurred. Both categories influence the chance of the disease ultimately developing.

From the above abstracts (which should be taken with a grain of salt) it would appear that PS is used by normally functioning (or rather, normally dying) cells as well as pathogens to indicate that an immune response should not be mounted against proteins found on the cell when it is consumed by phagocytes. This would suggest that PS is important in preventing autoimmune pathologies (helping prevent false positives) but also used by pathogens to prevent adaptive immune responses to their surface proteins (essentially, causing false negatives). The treatment idea here seems to be to starve cells of PS, however that does not necessarily mean that supplementation beyond normal intake would have any impact upon the immune system's ability to identify and destroy cancerous cells.

That being said, we should probably read the papers rather than speculate based solely upon the abstracts.

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[gamesguru]

We are not living longer these days.  Millenials are coming down with more cases of heart disease and colon cancer in their twenties than any previous generation on record.  We stuff our faces with twinkies, sit on our couches, and write insincere comments on our friends' instagrams.  How long til that kind of lifestyle catches up with you?

 

Generally on a good diet, other things will balance out the T-cells (which PS lowers).  But you really have to do your homework, because if you decided to eat a lot of, say red onions.. you'd be in trouble because quercetin has a similar effect in lowering dendritic T-cells count.  IME regular button mushrooms can act as sort of a buffer in either direction, they help my allergies and colds (kind of how chicken soup lowers the immune response and makes you feel better).  Broccoli is another underdog in terms of boosting the immune system, especially in the elderly.  Oranges not so much.

 

It might be irrelevant, rogue stem cells are what keep tumors growing.  It is not the local tissue so much as distant soldiers being called to the site.  Therefore, although it is true these things suppress the beloved T-cell (a helpful immune/white blood cell against cancer) they also suppress the dreaded cancerous stem cells.  Perhaps the net result is anti-cancerous?  Who knows..

 

Phosphatidylserine has other redeeming qualities too.. it lowers cortisol, is a vital component of cell membranes, and may behave similarly to D-serine

[Duchykins]

We are not living longer these days.  Millenials are coming down with more cases of heart disease and colon cancer in their twenties than any previous generation on record.  We stuff our faces with twinkies, sit on our couches, and write insincere comments on our friends' instagrams.  How long til that kind of lifestyle catches up with you?

 

 

 

That statement was made in the context of evolutionary timescales... but okay.

[gamesguru]

Yeah, you've got a point.  If you do.  Because I think it was a lot more common than many people give credit for, to see "cavemen" living into their 40s and 50s.  Especially for the high ranking man whose adult existence would consist of being fanned and fed olives while he gives orders to the lower ranks and relates self-flattering stories to beautiful women.  We weren't really around to see the genetics diseases experienced by paleolithic man.  Heaven is a very crowded place.  Over 45 billion people were born before Christ many of them between 8000 B.C. and 0 A.D, and I can assure that the sheer numbers and lack of sophistication compensate for the lack of pollution and modern stressors.. a time traveler would witness some horrific genetic mutations which were however lost to history.  A lot of the tribal medicine (e.g. voodoo magic) is nothing more than a violent reaction to unexplained cases of epilepsy, kids being born with three legs and a tail, etc

 

I just wanted to make my point about how things that suppress the T-cells also often suppress rogue stem cells.  They also suppress healthy stem cells, which sounds scary, but the organs are able sustain them with surprising resilience.  If it were not for this, many anti-cancer drugs (which inhibit cell division!!) would invariably result in tragedy.  So amen to that, and amen to you.

Edited by gamesguru, 16 March 2017 - 09:56 PM.

[Duchykins]

You know what's weird about what you said about Millennials?  Their disease rates.  This is quite interesting because part of what defined the Millennial generation is high levels of unemployment, greater willingness to work longer hours for less pay, general economic upheaval, many having to move back in with parents after getting college degrees, the kind of stuff that Gen X didn't experience much.  I feel certain that environment played a role.

Edited by Duchykins, 17 March 2017 - 12:11 AM.