6 replies to this topic

[meatwad]

So does Niacin cause DNA telomere damage or not?

1g at night time effectively stops phantom voices for me,
if it conclusively does damage I would love to know.

[trh001]

I've seen references to excess niacin using up methyl equivalents (certain molecules donate methyl groups in Niacin metabolism) which are otherwise unavailable for other purposes. Lack of sufficient methylation of DNA could be associated with genetic "unsilencing" of genes that should be kept from being expressed. This may be what's being addressed in references to DNA damage. I'm not familiar with telomere damage, specifically.

It's suggested that folate, B12, TMG, and Choline can take part in methyl donation reactions, so you might want to supplement with these to compensate for excess niacin intake.

On the other hand, all of the references I see on a quick-n-dirty search suggest lack of niacin results in increased risk of DNA damage. For example, niacin is required in RDA levels to ensure DNA repair process integrity (see below).


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Nutr Cancer. 2003;46(2):110-8. Related Articles, Links


Niacin and carcinogenesis.

Kirkland JB.

Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

The dietary status of niacin (vitamin B3) has the potential to influence DNA repair, genomic stability, and the immune system, eventually having an impact on cancer risk, as well as the side effects of chemotherapy in the cancer patient. In addition to its well-known redox functions in energy metabolism, niacin, in the form of NAD, participates in a wide variety of ADP-ribosylation reactions. Poly(ADP-ribose) is a negatively charged polymer synthesized, predominantly on nuclear proteins, by at least seven different enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is responsible for the majority of polymer synthesis and plays important roles in DNA damage responses, including repair, maintenance of genomic stability, and signaling events for stress responses such as apoptosis. NAD is also used in the synthesis of mono(ADP-ribose), often on G proteins, with poorly understood roles in signal transduction. Last, NAD and NADP are required for the synthesis of cyclic ADP-ribose and nicotinic acid adenine dinucleotide (NAADP), two mediators of intracellular calcium signaling pathways. Disruption of any of these processes has the potential to impair genomic stability and deregulate cell division, leading to enhanced cancer risk. There are various sources of evidence that niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations.

Publication Types:
Review

PMID: 14690785 [PubMed - indexed for MEDLINE]

[trh001]

I did a search of niacin and telomere and nothing came up, however, niacinAMIDE, is probably not good in excess (you're not taking niacinamide are you?) per what's being seen wrt the Sirtuin gene family and aging:

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J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23. Related Articles, Links


Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase that plays a critical role in transcriptional silencing, genome stability, and longevity. A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis. The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B(3). We show here that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. We show that physiological concentrations of nicotinamide noncompetitively inhibit both Sir2 and SIRT1 in vitro. The degree of inhibition by nicotinamide (IC(50) < 50 microm) is equal to or better than the most effective known synthetic inhibitors of this class of proteins. We propose a model whereby nicotinamide inhibits deacetylation by binding to a conserved pocket adjacent to NAD(+), thereby blocking NAD(+) hydrolysis. We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes.

PMID: 12297502 [PubMed - indexed for MEDLINE]

[th3hegem0n]

phantom voices

...?

[syr_]

I did a search of niacin and telomere and nothing came up, however, niacinAMIDE, is probably not good in excess (you're not taking niacinamide are you?) per what's being seen wrt the Sirtuin gene family and aging:

You mean that nicotinamide + niacin = niacinamide?

[focus]

1g at night time effectively stops phantom voices for me

Are these voices like in the closet or in your mind?

[meatwad]

Depending on who I have spent alot of time with, I can usually have 'conversations' or hear their voices pitch perfect. Like my grandmother or my friends, If i have spent a few hours with them then their thought/speech patterns get stuck into my brain. -- when I go to sleep I take a g of niacin and it goes away and I sleep fine.