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Biological Age

anti-aging

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#211 Michael Lustgarten

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Posted 28 April 2021 - 11:39 PM

No, because my circulating levels of albumin are correlated with a higher intake of beta-carotene (see https://youtu.be/Hvk1wvDmlms?t=396). So I purposefully eat a lot of carrots and spinach!

 


Edited by Michael Lustgarten, 28 April 2021 - 11:40 PM.


#212 Lady4T

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Posted 29 April 2021 - 05:45 AM

No, because my circulating levels of albumin are correlated with a higher intake of beta-carotene (see https://youtu.be/Hvk1wvDmlms?t=396). So I purposefully eat a lot of carrots and spinach!

 

How about eggs?

 

"A raw U.S. large egg contains around 33 grams of egg white with 3.6 grams of protein,. . . "  "Ovalbumin is the most abundant protein in albumen."

https://en.wikipedia.../wiki/Egg_white

 

According to that, one large egg contains around 54% ovalbumin (about 1.9 grams).

Does eating more eggs help increase serum albumin?


Edited by Lady4T, 29 April 2021 - 05:53 AM.

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#213 Michael Lustgarten

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Posted 29 April 2021 - 11:04 AM

Yes, I'm familiar-I've tracked my daily food intake since 2018, and I have 14 blood tests during that period. In that data, egg intake is not correlated with blood levels of albumin (= 0.02, p=0.95). One reason may be because albumin is a large protein that is digested into its constituent amino acids prior to absorption. Then, it would be up to the liver to reassemble it into albumin, which would seem to be problematic because blood levels of albumin decrease during aging. Nonetheless, other mechanisms seem to be involved (for me), but we all may respond differently, and I'd encourage giving eggs a try to see if it works.



#214 Michael Lustgarten

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Posted 02 May 2021 - 10:22 AM

Here are the results of my 2nd blood test in 2021:
 

https://www.youtube....h?v=G5zXa4DLvjY



#215 albedo

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Posted 02 May 2021 - 12:57 PM

Here are the results of my 2nd blood test in 2021:
 

https://www.youtube....h?v=G5zXa4DLvjY

 

Thank you Michael !

 

Two comments/questions:

  1. I am not sure about when you say the max BA reduction is about 20 years. Why?
  2. The 3.7x increase in hs-CRP in the 2nd measurement in 2021 might simply mean your body is working against a sub-clinical infection. What is your average hs-CRP since you start measuring it? The increase might be resolving soon. I would be cautious on conclusions after the MUFA test (what will you be increasing? – sound was not clear)

 

 



#216 Michael Lustgarten

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Posted 02 May 2021 - 06:27 PM

 

Thank you Michael !

 

Two comments/questions:

  1. I am not sure about when you say the max BA reduction is about 20 years. Why?
  2. The 3.7x increase in hs-CRP in the 2nd measurement in 2021 might simply mean your body is working against a sub-clinical infection. What is your average hs-CRP since you start measuring it? The increase might be resolving soon. I would be cautious on conclusions after the MUFA test (what will you be increasing? – sound was not clear)

 

 

Thanks albedo. If you plug in your data to Levine's test, then change your chronological age, you'll see that the maximal biological age reduction is ~20y. So even if you're 80 with youthful biomarkers, at best you're 60. To me, that doesn't add up.

 

I agree about sub-clinical infection. However, my previous blood test was 0.27, and I've been in the 0.2 - 0.3 range, so I'd like to identify the variables that keep me there, rather than at my ~0.5 mg/L average since 2018. To increase MUFA intake, I'll increase my almond and cashew intake, which are mostly MUFA-containing nuts.


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#217 albedo

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Posted 03 May 2021 - 04:19 PM

Thanks albedo. If you plug in your data to Levine's test, then change your chronological age, you'll see that the maximal biological age reduction is ~20y. So even if you're 80 with youthful biomarkers, at best you're 60. To me, that doesn't add up.

 

I agree about sub-clinical infection. However, my previous blood test was 0.27, and I've been in the 0.2 - 0.3 range, so I'd like to identify the variables that keep me there, rather than at my ~0.5 mg/L average since 2018. To increase MUFA intake, I'll increase my almond and cashew intake, which are mostly MUFA-containing nuts.

 

1. Thanks, I understand. It is why I am a bit skeptic on the BA number: it is a guideline but fundamentally it is just a mean to convert in years a (10 years) mortality risk using Gompertz's law.  I rather like the approach you are having of taking all those 9 biomarkers, themselves emerging from stringent statistical methods when regressing on cross sectional large population data, and then optimize against ACM.

 

2. hs-CRP is highly important and I am eager to know the results of your tests.

 

 


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#218 albedo

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Posted 25 August 2021 - 08:12 AM

To be short I just point here to a couple of comments I made into another interesting forum thread (age reversal network) in case you follow that too:

https://forum.age-re...dna-methylation


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#219 resting

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Posted 23 October 2021 - 03:44 PM

Just had my MUHDO Epigenetic results.   FYI

 

Chronological age 56  vs Biological Age 45.3

 

Should be lower but last 18 months been problematic due to Sars2 etc.

I had  practiced hormesis and OMAD + Daily 20m @ 80c  in  sauna for 2 years + swimming.  The results also show massive inflammation (probably due to time sample was given).

 

All the general supplements and experiments with (you may find posts relating).   Grandfather was 100 years when died. (Intensionally)  Father  83 (diagnosed and treated from age of  68 Prostate / health care maintenance issues due to Sars2 ... did not have virus). NMN + LIPO supplements.  Getting back to some form of better health now so will be back to sauna / swimming which is the only component missing at the moment).

 

 

 


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#220 johnhemming

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Posted 31 December 2021 - 08:25 AM

I thought I would try out one of the online services that claim to offer EpiGenetic age testing.

I picked this one

https://epi-age.com/

Which is this company

HKG Epitherapeutics - Hong Kong Unit 119, 1/F Biotech Centre 2, 11 Science Park West Avenue Hong Kong Science Park, Shatin, NT, Hong Kong, HK,

https://www.hkgepitherapeutics.com

(+852) 2354 8297

info@hkgepitherapeutics.com

This is an area where I would really like to have the Horvath test, but as a second option I have picked one of the online tests.  I would not pick a test which required my chronological age and the above didn't.

It prices at USD199.

I don't remember precisely when I ordered the kit, but it arrived and I did the test and sent it off (which is spitting into a test tube) on 3rd December 2021.  I posted it to Hong Kong using a tracker.

I was mildy nervous that their app said they had received the package almost immediately when the tracker said it did not arrive until 12th December.   However, they emailed me overnight that the test was done on 30th December.   If they are queueing up tests I would not complain.  It implies they are doing well in terms of demand and 3 weeks is not the end of the world in terms of processing delay.

The resultant EpiAge is 56.21 my actual chronological age is  61.79 and they say this Epi Age correlates to an age of 52.24.

I don't think the correlation means anything it would depend in part on what age people say they are when they contact them and you are not required to submit an age. Sadly this is my first test result so I don't have anything to compare against.  I think I will try them out again probably at the half year although I am also interested in using any other online test that people recommend as being of some meaning.

I am also tracking a number of other things which are easy to measure such as high frequency hearing loss, grip strength etc.  However, it is all a bit erratic really as I have not got much in terms of a baseline.

In terms of visual changes I have publicly what is on my (and someone else's) twitter account

https://twitter.com/...678861457432583

https://twitter.com/...381767866441728

and

https://twitter.com/...356229509660672


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#221 albedo

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Posted 12 January 2022 - 12:17 PM

A recent review:

 

Xian Xia, Yiyang Wang, Zhengqing Yu, Jiawei Chen, Jing-Dong J. Han,
Assessing the rate of aging to monitor aging itself
https://doi.org/10.1...arr.2021.101350.

 

Abstract: Healthy aging is the prime goal of aging research and interventions. Healthy aging or not can be quantified by biological aging rates estimated by aging clocks. Generation and accumulation of large scale high-dimensional biological data together with maturation of artificial intelligence among other machine learning techniques, have enabled and spurred the rapid development of various aging rate estimators (aging clocks). Here we review the data sources and compare the algorithms of recent human aging clocks, and the applications of these clocks in both researches and daily life. We envision that not only more and multiscale data on cross-sectional data will add momentum to the aging clock development, new longitudinal and interventional data will further raise the aging clock development to the next level to be trained by true biological age such as morbidity and mortality age.


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