9 replies to this topic

[stefdude]

Hello.I'm looking for something to help my father (age 56) with his worsening memory.His doctor gave him fish oil and benfotiamine(+thiamine), but honestly, he isn't keeping the schedule very well.

 

Any good stack for this?I'm also considering racetams.Also, any specific blood tests to check for deficiencies?

[PeaceAndProsperity]

Niacin in the form of nicotinic acid is very good for all sorts of age-related diseases. SAMe is also very good. Add in some carnitine of your choice. That's a very effective combo from everything from heart disease to cognitive decline.

[Kabb]

PeaceandProsperity's niacin and carnitine seem like reasonable supplements to try but are not my immediate first choice.

 

Memory impairment in the form of dementia is treated clinically by only a few type of medication.  The main class, typified by donepezil, seeks to increase choline and this may be an avenue worth exploring either by using donepezil-type meds or taking choline supplements.

 

I would also add B-complex vitamins as this is relatively cheap and sometimes can be very effective.

 

My own personal favourite to improve cognition in older people is to take arginine (5g) in order to reduce any circulating ammonia because later-life muscle wasting can mean ammonia extraction is poorer and tiny amounts of ammonia are hugely disruptive on the brain.  Alternatively you can take branched-chain amino acids (3g) from a sports supplier to get a similar effect.

 

 

 

[hdl_1]

My own personal favourite to improve cognition in older people is to take arginine (5g) in order to reduce any circulating ammonia because later-life muscle wasting can mean ammonia extraction is poorer and tiny amounts of ammonia are hugely disruptive on the brain. Alternatively you can take branched-chain amino acids (3g) from a sports supplier to get a similar effect.

L-Ornithine is a better candidate than L Arginine to reduce ammonia.

https://www.ncbi.nlm...pubmed/10462368

versus

http://www.sciencedi...002934357902954

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[Kabb]

 

My own personal favourite to improve cognition in older people is to take arginine (5g) in order to reduce any circulating ammonia because later-life muscle wasting can mean ammonia extraction is poorer and tiny amounts of ammonia are hugely disruptive on the brain. Alternatively you can take branched-chain amino acids (3g) from a sports supplier to get a similar effect.

L-Ornithine is a better candidate than L Arginine to reduce ammonia.

https://www.ncbi.nlm...pubmed/10462368
versus
http://www.sciencedi...002934357902954

 

The urea cycle extracts ammonia and it is rate-limited by ornithine, so that is always a good choice but if you read your references closely they do not say ornithine fully supplants arginine.  In fact, depending on where in the urea cycle there is a problem (if any) arginine may be indicated and ornithine not.  Arginine (and citrulline) also serves another purpose by promoting nitric oxide production which is a compound that can reduce ammonia - notably in the nervous system.

 

Theory apart, my own experience is that arginine is more reliably effective than ornithine although there are some odd times when ornithine has it's own definite benefit.

 

Branched-amino acids are an interesting alternative to amino acids to deal with hyperammonemia although their exact mechanism is poorly understood.  However they have a quick and pronounced effect.

Edited by Kabb, 20 April 2017 - 10:45 AM.

[PeaceAndProsperity]

FYI my now 71 relative's cognitive functioning improved considerably from a mix of supplements but I would guess it is primarily niacin in the form of nicotinic acid.

 

Some paper was published that showed that the formation of new blood vessels is necessary for the creation of new memories or something like that. Well niacin directly increases the production of new blood vessels (touted as a spooky mechanism of potentially worsening cancer.. Boooohhhh! Spoooky cancer!)

Can't remember if it was this study, I have got to go now..

https://www.ncbi.nlm...pubmed/20804819

[csimon02]

Intranasal insulin. Check the lostfalco thread for more info.

https://selfhacked.c...anasal-insulin/

Edited by csimon02, 20 April 2017 - 02:33 PM.

[stefdude]

I was too busy these days.Thank you all for the suggestions, I'll look into it.

I'm thinking Benfotiamine(+thiamine) + the rest suggestions of the b complex + choline + carnitine and arginine.I'll check the dosages and post a stack the next days.

I have BCAA but no way he will take the unflavored powder, so I will leave it out for now.Sam-e also, due to its price.I'll try it last.

 

I'll download an app to his mobile to make sure he is taking everything every day.I hope he sees some improvement in the first couple of weeks because he is not very fond of supplements.

 

Please keep the thread going, if you have any other ideas.I think it's a common problem.

[stefdude]

Intranasal insulin. Check the lostfalco thread for more info.

https://selfhacked.c...anasal-insulin/

 

I like this idea too.I was reading the other day about a possible common mechanism between diabetes and alzheimeres.I'll read it through tomorrow, I desperately need some sleep now.

[justmodz]

I was too busy these days.Thank you all for the suggestions, I'll look into it.

I'm thinking Benfotiamine(+thiamine) + the rest suggestions of the b complex + choline + carnitine and arginine.I'll check the dosages and post a stack the next days.

I have BCAA but no way he will take the unflavored powder, so I will leave it out for now.Sam-e also, due to its price.I'll try it last.

 

I'll download an app to his mobile to make sure he is taking everything every day.I hope he sees some improvement in the first couple of weeks because he is not very fond of supplements.

 

Please keep the thread going, if you have any other ideas.I think it's a common problem.

 I would say that the benofotiamine should be be changed for sulbutiamine if you look at this study

 

https://www.ncbi.nlm...les/PMC2435522/

 

and this one

 

https://www.ncbi.nlm...pubmed/17675917

 

I haven't been able to find prescribing information on it in the UK but have come up with it being prescribed in The Philippines, India and Hong Kong and this is what the prescribing pharmacology says has a specific neurotrophic action. This results in better physical resistance, improved intellectual performance and psychological balance.

Sulbutiamine is related to thiamine.

 

 

 

 

Edited by justmodz, 17 March 2018 - 01:23 PM.