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niacinamide plus ribose as effective as NR?


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#1 StanG

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Posted 22 May 2017 - 02:52 PM


Bryan_S - for you mainly - what do you think of this post, posted in another blog and why:

 

 

Do you find taking niacinamide plus ribose as effective as commercial NR?

 

 

It's more effective. For NAD+, supplements appear to be effective in the following sequence: nicotinic acid < nicotinamide < NR < nicotinamide + ribose

 

Note that nicotinamide is the same as niacinamide, and nicotinic acid is the same as niacin.

 

Nicotinamide + a greater than stoichiometric  dose of ribose should be more effective than NR, as NR must be enzymatically broken down into nicotinamide + ribose to be absorbed. Since some ribose will be lost, not all will be recombined, and there is a several hour delay before it reaches its maximum effect for that same reason. Thus the 2 g nicotinamide + 5 g ribose dose I'm using should be equivalent to > 4 g NR.

 

See the following paper--

 

 

Perfused or intact intestine rapidly hydrolyzed NMN to nicotinamide riboside, which accumulated, but was not absorbed. It was slowly cleaved by an enzyme associated with the mucosal cells to nicotinamide, which was the major if not the only labeled compound absorbed.

 

http://nadh.wiki/wp-...-of-the-Rat.pdf

 



#2 Michael

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Posted 22 May 2017 - 04:11 PM

Bryan_S - for you mainly - what do you think of this post, posted in another blog

 
(Always best to link or at least clearly cite sources, including "other blogs").
 

Do you find taking niacinamide plus ribose as effective as commercial NR?
 
It's more effective. [..]Nicotinamide + a greater than stoichiometric  dose of ribose should be more effective than NR, as NR must be enzymatically broken down into nicotinamide + ribose to be absorbed. Since some ribose will be lost, not all will be recombined, and there is a several hour delay before it reaches its maximum effect for that same reason. Thus the 2 g nicotinamide + 5 g ribose dose I'm using should be equivalent to > 4 g NR.
 
See the following paper--
 

Perfused or intact intestine rapidly hydrolyzed NMN to nicotinamide riboside, which accumulated, but was not absorbed. It was slowly cleaved by an enzyme associated with the mucosal cells to nicotinamide, which was the major if not the only labeled compound absorbed.
 
http://nadh.wiki/wp-...-of-the-Rat.pdf


We've discussed this hypothesis (once again stated as fact rather than as the hypothesis that it is) several times before: see especially here and, in more detail, here.


Edited by Michael, 22 May 2017 - 07:11 PM.

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