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Proteins and carbs + macros proportions

health life long macros

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#1 Snejks

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Posted 11 June 2017 - 01:45 AM

Welcome, someone know thats true high protein and high carb diet short life?
What macros(Prot./Carb./Fat) proportions are very good for healthy man?

#2 ekaitz

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Posted 22 June 2017 - 10:32 PM

I always liked the 50/30/20 carb/fat/protein.

Edited by ekaitz, 22 June 2017 - 10:33 PM.

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#3 mccoy

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Posted 01 July 2017 - 11:57 AM

There are so many theories and experiments but little facts on humans.


On lab mice the literature suggests that a very high carb diet with little protein (C/P ratio = 10) increases longevity.

In humans, in the longevity-prone blue zone areas people tend to eat  prevalently carbs, with fats and protein subordinate. healthy food, like vegetables, natural starch, fruit, nuts & seeds, little animal protein, usually



Ageing Res Rev. 2017 Mar 6. pii: S1568-1637(17)30046-6. doi: 10.1016/j.arr.2017.03.001. [Epub ahead of print]

Dietary protein, aging and nutritional geometry.



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#4 Darryl

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Posted 02 July 2017 - 10:49 PM

Little experimental evidence in humans, but the animal studies are very consistent: protein restriction extends lifespan. And in humans, higher protein intake, at least from high methionine animal sources, increases cardiometabolic risk and all-cause mortality among the middle aged. As you'll note from the refs below, its a lively topic of research of late, particularly at the Charles Perkins Centre, University of Sydney, and in Valter Longo's lab at USC Leonard Davis School of Gerontology.


Given true protein and or methionine restriction is not particularly practical for the weak-willed like myself, I aim for protein and methionine moderation, a high ratio of (glycine+serine)/(methionine+cysteine) (ie, legumes/nuts for protein), and periodic fasts. The animal evidence makes a compelling case that caloric restriction practitioners that achieve satiety through high protein diets may be undermining the benefits.


Recent studies/reviews focusing on animal protein restriction experiments:


Sanz et al, 2004. Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liverJournal of bioenergetics and biomembranes36(6), pp.545-552.

Nakagawa et al, 2012. Comparative and meta‐analytic insights into life extension via dietary restrictionAging cell11(3), pp.401-409.

Mirzael et al., 2014. Protein and amino acid restriction, aging and disease: from yeast to humansTrends in Endocrinology & Metabolism25(11), pp.558-566.

Solon-Biet et al, 2014. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed miceCell metabolism19(3), pp.418-430.

Solon-Biet et al, 2015. Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in miceCell reports11(10), pp.1529-1534.

Shim and Longo, 2015. A protein restriction-dependent sulfur code for longevityCell160(1), pp.15-17.

Simpson et al, 2015. Putting the balance back in dietCell161(1), pp.18-23.

Mirzaei et al, 2016. The conserved role of protein restriction in aging and diseaseCurrent opinion in clinical nutrition and metabolic care19(1), pp.74-79.

Le Couteur et al, 2016. The impact of low-protein high-carbohydrate diets on aging and lifespanCell Mol Life Sci73(6), pp.1237-52.

Le Couteur et al, 2016. Dietary protein, ageing and the Okinawan ratioAge and ageing45(4), pp.443-447.

I'll skip the methionine restriction experiments/reviews, as I'd be here all night.

Recent human epidemiology favoring lower protein intake:

Virtanen et al, 2006. High dietary methionine intake increases the risk of acute coronary events in middle-aged menNutrition, metabolism and cardiovascular diseases16(2), pp.113-120.

Halbesma et al, 2009. High protein intake associates with cardiovascular events but not with loss of renal functionJournal of the American Society of Nephrology20(8), pp.1797-1804.

Levine et al, 2014. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older populationCell metabolism19(3), pp.407-417.


Hernández-Alonso et al, 2016. High dietary protein intake is associated with an increased body weight and total death riskClinical Nutrition35(2), pp.496-506.

Malik et al, 2016. Dietary protein intake and risk of type 2 diabetes in US men and womenAmerican journal of epidemiology183(8), pp.715-728.

Song et al, 2016. Association of animal and plant protein intake with all-cause and cause-specific mortalityJAMA internal medicine176(10), pp.1453-1463.

Xu et al, 2016. Excess protein intake relative to fiber and cardiovascular events in elderly men with chronic kidney diseaseNutrition, Metabolism and Cardiovascular Diseases26(7), pp.597-602.

Shang et al, 2016. Dietary protein from different food sources, incident metabolic syndrome and changes in its components: An 11-year longitudinal study in healthy community-dwelling adultsClinical Nutrition.

Shang,et al, 2016. Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studiesThe American journal of clinical nutrition, p.ajcn140954.

Azemati et al, 2017. Animal protein intake is associated with insulin resistance in Adventist Health Study-2 (AHS-2) calibration participants: A cross-sectional analysisCurrent Developments in Nutrition, pp.cdn-116.

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