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AGE Breakers

age breaker supplement age oxidation

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#1 Jeff1

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Posted 19 July 2017 - 06:36 AM


After over a year of searching, I've found a reliable source to purchase  tetrahydroxystilbene-glucoside and rosemarinic acid. 

 

For those of you who are not aware, these are two of the most promising AGE breakers.

 

The supplier requires a minimum quantity of over 3 kilogram of each (in powder form) and am interested in a group buy. If anyone is interested, please let me know. 


Edited by Jeff1, 19 July 2017 - 06:38 AM.

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#2 meatsauce

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Posted 19 July 2017 - 04:33 PM

Yea I am. The powders need to be tested though. 



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#3 Benko

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Posted 19 July 2017 - 08:40 PM

Yea I am. The powders need to be tested though. 

 

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#4 tintinet

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Posted 19 July 2017 - 10:11 PM

2+



#5 PWAIN

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Posted 20 July 2017 - 07:21 AM

Do you have any quantity/pricing? Eg. 100 grams for $? I may be in depending on that.

#6 Jeff1

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Posted 20 July 2017 - 07:16 PM

Here are some preliminary figures:

 

10% tetrahydroxystilbene-glucoside powder:  30 cents per gram

20% rosemarinic acid powder:   25 cents  per gram

 

Does anyone have experience with a good lab for testing purposes?  I imagine this would be quite expensive to have tested, but I have not checked into it.


Edited by Jeff1, 20 July 2017 - 07:43 PM.


#7 PWAIN

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Posted 20 July 2017 - 09:30 PM

Thanks Jeff, that sounds reasonable. Couple more questions. What is in the other 90 and 80%? I'm mostly worried if it is harmful? Also what sort of dose would be typical? Is it something that would be take daily or on off from time to time?

#8 meatsauce

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Posted 21 July 2017 - 06:25 AM

Here are some preliminary figures:

 

10% tetrahydroxystilbene-glucoside powder:  30 cents per gram

20% rosemarinic acid powder:   25 cents  per gram

 

Does anyone have experience with a good lab for testing purposes?  I imagine this would be quite expensive to have tested, but I have not checked into it.

Yea I do. Its not that much. I think a few hundred per compound if we do the heavy metal testing.



#9 Jeff1

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Posted 21 July 2017 - 06:46 AM

Thanks Jeff, that sounds reasonable. Couple more questions. What is in the other 90 and 80%? I'm mostly worried if it is harmful? Also what sort of dose would be typical? Is it something that would be take daily or on off from time to time?

 

These are both plant extracts to specified concentrations. The rest is the remaining plant material after extract:

 

10% tetrahydroxystilbene-glucosid is from Polygonum Multiflorum Thunb.

20% rosemarinic acid powder is from  Rosemary Leaf

 

The supplier will purify these to higher concentrations if requested, but the price increases proportionately, and this makes the cost of buying a few kilograms much higher. 

 

Personally, I would probably use around 1 gram of extract per day.  I am determined to break my AGEs, so I may be more aggressive than others in dosage. 



#10 Jeff1

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Posted 21 July 2017 - 06:48 AM

 

Here are some preliminary figures:

 

10% tetrahydroxystilbene-glucoside powder:  30 cents per gram

20% rosemarinic acid powder:   25 cents  per gram

 

Does anyone have experience with a good lab for testing purposes?  I imagine this would be quite expensive to have tested, but I have not checked into it.

Yea I do. Its not that much. I think a few hundred per compound if we do the heavy metal testing.

 

I see.  How large of a sample do we need?  I already have a 10 gram sample of the TS-G powder.


Edited by Jeff1, 21 July 2017 - 06:48 AM.


#11 meatsauce

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Posted 21 July 2017 - 04:21 PM

 

 

Here are some preliminary figures:

 

10% tetrahydroxystilbene-glucoside powder:  30 cents per gram

20% rosemarinic acid powder:   25 cents  per gram

 

Does anyone have experience with a good lab for testing purposes?  I imagine this would be quite expensive to have tested, but I have not checked into it.

Yea I do. Its not that much. I think a few hundred per compound if we do the heavy metal testing.

 

I see.  How large of a sample do we need?  I already have a 10 gram sample of the TS-G powder

I think just a gram or two



#12 Jeff1

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Posted 27 July 2017 - 01:48 AM

 


I think just a gram or two

 

 

Can you check on and confirm the cost to get the TSG tested?.  I can send a couple of grams to the lab. I don't know how to coordinate cost sharing. Perhaps I can be responsible for purchasing the product if someone else will pay for the testing.  Open to other arrangements too.



#13 meatsauce

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Posted 27 July 2017 - 02:20 AM

OK I'll have to see what needs to be done to verify the material its best if there is a legit reference material to match the hplc with.

#14 stefan_001

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Posted 27 July 2017 - 09:04 PM

Both compounds seem to be AGE inhibitirs but havent see good data indicating they break bonds.

Edited by stefan_001, 27 July 2017 - 09:05 PM.

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#15 normalizing

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Posted 28 July 2017 - 04:34 AM

hmm i thought tetrahydroxystilbene is already sold as supplement over the internet. at least, i have seen various stilbene forms being sold, im pretty sure this one can be found too as well as rosemarinic acid



#16 Jeff1

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Posted 28 July 2017 - 05:08 AM

hmm i thought tetrahydroxystilbene is already sold as supplement over the internet. at least, i have seen various stilbene forms being sold, im pretty sure this one can be found too as well as rosemarinic acid

 

 

Both compounds seem to be AGE inhibitirs but havent see good data indicating they break bonds.

 

See this study for AGE breaking ability of rosmarinic acid: http://www.toukastre...015/GS15-26.pdf

 

The only supplement I've seen which contains tetrahydroxystilbene-glucoside is fo-ti root capsules which contain unquantified amounts of TSG.  The problem with that supplement is that you don't know how much TSG you are getting. 


Edited by Jeff1, 28 July 2017 - 05:09 AM.

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#17 normalizing

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Posted 28 July 2017 - 05:24 AM

jeff, there are various pterostilbene supplements too, did you look into these? they dont state exactly the form, but i assume it can that one, no? we are talking about pterostilbine that is present in blueberries, correct? im not well educated about how many forms of pterostilbene there are, but i think anything containing pterostilbene should be coming with the complete package.


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#18 Jeff1

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Posted 28 July 2017 - 06:06 AM

I'm aware of pterostilbene. 

 

See this excerpt from the study below:

 

"It was shown to efficiently inhibit the formation of AGEs in a dose-dependent manner by trapping reactive MGO under physiological conditions (pH 7.4, 37°C) [153]. More than 60% of MGO was trapped by THSG within 24 hours and THSG was much more effective than resveratrol and its methylated derivative pterostilbene (two major bioactive stilbenes) [153]"

 

https://cdn.intechop...fs-wm/39450.pdf


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#19 Nate-2004

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Posted 02 August 2017 - 08:29 PM

There is little evidence except in vitro that rosmarinic acid breaks crosslinks. The in vitro study involved carsonic as well as rosmarinic acid in a 98% pure extraction. You can get a max of 30% from Dynveo, a company owned by one of the members on Longecity. I tried getting the 98% from Sigma Aldrich but they won't sell to me. I wouldn't put too much stake in it breaking glucosepane crosslinks however, as the in vitro study did not reveal the type of AGE they were testing on. If it wasn't glucosepane then it's largely useless and a shot in the dark at best since we just don't know.  I've been taking rosmarinic acid off and on a lot with carnosine for the past year or so and honestly, I just don't know. Given what I know about AGEs and the fact that there are multiple pathways in glycation besides ROS and transition metals, we're probably better off breaking than trying to block. Does RA break? According to that study yes in vitro it breaks better than ALT-711 but even then, ALT-711 did not affect glucosepane or even pentosidine to my knowledge. These are two types of AGEs that are tough to break and the most common one is glucosepane. 

 

From what I understand, recently, Yale scientists in the Spiegel lab have successfully synthesized glucosepane in order to find drug candidates that break the crosslinks. 

 

What if they find the crosslink breaker, what then? They'll just reforge if you stop taking the drug, how do you sweep out the AGEs once the crosslinks are broken? Is that possible to do?


Edited by Nate-2004, 02 August 2017 - 08:30 PM.

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#20 Michael Lasky

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Posted 29 October 2017 - 12:40 PM

I ran across an interesting article on limonene and aminoguanidine (AG) synergy.    https://www.ncbi.nlm...pubmed/28274869     https://www.ncbi.nlm...pubmed/28274869  Suggests that aminoguanidine toxicity can be avoided by using limonene simultaneously - a reduction in required dose by 95%.   I ordered limonene from Jarrow, and AG from  naturaleyecare.com to give them a try.  Limonene itself has some very interesting potential benefits.  

   Limonene is the primary constituent of orange oil - and also likely present in significant amounts in citrus peels - so I'm thinking of adding powdered orange, lemon or grapefruit peel to my diet - to obtain all the other beneficial phytochemicals - I prefer to do the "whole food" route first, before trying isolated compounds.  My Darwinian perspective - we evolved in a complex environment.

 

Sesamin (only source I know of is Sesaplex from Swanson) also  has interesting properties, especially with P38-MAPK and NFkb - just started taking it - no perceived effects, as of yet.

 

Been taking ambroxol HCL (available from European vendors - I get it from a German vendor on Ebay) - for 4 months with unexpected large benefits re: lung function / colonization - if anyone is interested or has that problem (pseudomonas aeruginosa) - I can share my experience.

 

I've read about rosmarinic acid - thought it works at very low doses - why not just powder some rosemary and take that as a first step?  See if that has any perceivable benefits.   


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#21 APBT

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Posted 29 October 2017 - 02:28 PM

I ran across an interesting article on limonene and aminoguanidine (AG) synergy.    https://www.ncbi.nlm...pubmed/28274869    Suggests that aminoguanidine toxicity can be avoided by using limonene simultaneously - a reduction in required dose by 95%.

FULL TEXT:  


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#22 Michael Lasky

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Posted 30 October 2017 - 11:11 AM

Many thanks APBT - lots of additional info



#23 Nate-2004

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Posted 30 October 2017 - 01:48 PM

This sounds like an effective inhibition of pentosidine but they make no mention of glucosepane, which is strange that they would not even test or mention that unless it's not even a product of the type of glycation they were targeting. This is also in vitro so not even mice were involved here.

 

As a blocker it's going to be expensive considering the accessibility of aminoguanidine and that you wouldn't even see results for 10 years, though you could do some blood panels in a year to determine whether some things are improving, like A1c. 


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#24 Jeff1

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Posted 20 July 2018 - 03:50 PM

I was able purchase tetrahydroxystilbene-glucoside.   Is anyone interested in having this tested? 







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