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Childhood ALL survivor, anxiety, depression, ocd, brain fog r-ketamine?

ketamine depression ocd anxiety ptsd hydroxinorketamine brain fog cfs add-pinfection

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#1 long3vity

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Posted 27 July 2017 - 07:39 PM


Symptoms: Major depression, Anxiety, OCD, Extreme fatigue, Horrible memory

 

Medicines I take now: 0.25-0.5 mg xanax for GAD and OCD, 50 mg Dexedrine for ADD-PI and chronic fatigue, recently started on 168 mg lithionit (lithiumsulfate), and 25-50 mg seroquel + 1,25-2,5 mg olanzapine for sleep and to reduce side effects from dexedrine.

 

Effects of R-ketamine: Highly anxiolytic reduces OCD. Fluidity of thoughts, something that I have never experienced before. Easier to remember movie lines. Easier to multitask. learn piano-pieces faster, coordination is much better, learning dance routines much easier. I just feel very free and not so in my head. Memory is enhanced to the point where I actually start noticing and remembering what people were wearing in movies and in real life. It’s somehow helping my working memory so I can process multiple bits of information at the same time. Alleviates my CFS-symptoms and a lot of my ADD-PI symptoms too. I could reduce my medicines with almost no side-effects. I would go days without benzo and not feel withdrawals. I’ve been taking xanax for 2 years now.

 

My OCD: I don’t have an OCD-diagnosis but I seem to have strong OCD-tendencies with excessive rumination leading virtually nowhere, it’s just these negative demeaning thought loops that will popup randomly causing me to almost freeze in anxiety. I can sometimes have this intense fear of being ridiculed of or that i’m being judged by how I behave in a certain situation causing me to have a lot of anxiety for that situation so much that I start avoiding that situation. It could even be a person. Looking back on my life i’ve always had slight obsessive tendencies like being fascinated by sharks for a period of time, or airplanes, later on space etc. I brought this up with my psychologist during my neuropsychiatric investigation, asking her if I might be on the autism spectrum and although she admitted that could put me there, she said my ”emotional contact” and overall manner of being did not correspond with an autism-diagnosis. She did however diagnose me with ADD-PIGAD and PTSD 

 

My ADD-PI / SCT / CFS / Something? :

Inattentivess, brain fog, lack of energy, slow-thinking, slow-information processing, bad memory. All these symptoms I feel are more related to some form of Sluggish cognitive tempo or Chronic fatigue symptom. Can’t keep up in conversations (this is exacerbated by anxiety) but even when i’m watching movies at home by myself I seem to have a really hard time following the plot line. And it’s become worse over time. I also have really hard time with remembering routes. Like when I was walking with my friend to a place in the city, leaving the subway we had to walk for like 15 min to get to a place and we stayed in that place for 1 hour then I was totally dependent on my friend to find the place back to the subway.

 

I have general weakness on the left side of my body, which was notated by a neurologist three years ago. My left shoulder is slightly lower than my right. I have a numb area on my left shoulder, which I’ve had for atleast 5 years. I have an enlarged lymph-node on the left side of my neck and back of the head. I’ve had a fungal infection on my left foot for many years and I haven’t been able to get rid of it until recently. Also, rarely I can get blisters under my tongue and its always on the left side. I’m just curious if there could potentially be some kind of relationship between these symptoms?

 

I have chronic sinusitis, I’ve had near-anosmia for the last couple of years. Only thing that temporarily give my smell back is 100 mg seroquel which is a strong antihistamine. There’s more and more evidence that inflammation is playing a key role in some forms of depression especially treatment-resistant ones/major and glutamate exitoxicity could play a role in neurodegenerative disorders, bipolar, add, brain inflammation caused by infections.

 

I’ve had some weird reactions to substances, which I can’t explain 

 

Reaction to smoking a cigarette: Sitting at a bar with my friends, I rarely smoke and given my cancer background I do best in avoid it. My friend offers me one and i’m like fk it and take it, light it up and take some puffs. After a few minutes suddenly my hearing becomes hypersensitive. I can hear everything so loud I was so scared like wtf is going on?? voices, forks everything became so intense. 

 

This reminds me of one time when I took 36 mg concerta in class a couple years ago and had the same symptoms as above. I was doing a math problem when suddenly I became hyperaware of everything around me and I could hear everyone talking so loud and the sound of a someone toying with their pen and other writing in their books.. it was insane!

 

Cannabis: First time: 4 years ago I was outside with my friends as we were in a park we shared a joint, as we were starting to feel the effects we walked towards my friends house. This is when shit got weird, I kinda hyperfocused on my legs in the snow and was totally mezmerised by it somehow I couldn’t stop walking I almost walked into a pole but my friends managed to stop me. Then suddenly we were at my friends house. I was so confused and asked what had happened? Like did I hit myself anywhere? I suffered a 5 min memory gap. I frenetically checked myself in the mirror for some kind of damage to my brain and kept asking them am I okay???. Anyways, I calmed down and then the night went smoothly I was enjoying myself laughing with my friends, eating loads, listening to music. Nothing more really

 

First year high school (3 years ago) this is kinda where alot started

 

Then 6 months later I try cannabis again, however, this time through a bong and I accidently take too much into my lungs and soon start hyperventilating like crazy, I have the worst panic attack ever and although I calm down after awhile my friends actually notice me slightly hyperventilating even more than an hour after I smoked from the bong. 

Another time: Severe panic attack that I thought I would die.

And another time: severe paranoia, my friends looked like they had angry faces and when they talked it sounded really menacing. We were at my place so I told them I was really tired and needed to rest so I went to my room. After like an hour I went back to them but was very unresponsive and I had a hard time comphrehending what they were talking about. I think I was so paralyzed by anxiety, I also had intense spasms from my legs.

 

I’ve realized cannabis is definitely NOT for me.

And I don’t think any strong dopaminergics are good for me either so why do I take dexedrine? It’s the only thing besides r-ketamine that can keep me awake and it’s really hard to get r-ketamine in Sweden because it lacks psychotomimetics-side effects which are sought after by recreational users. As a matter of fact, I probably wouldn’t be able to write this post now if it wasn’t for dexedrine. I’m mitigating the risk of psychosis/mania by taking lithium, xanax and low dose olanzapine at night. As i’m really sensitive to olanzapine 2.5 mg or less is sufficient to get rid of any paranoia dexedrine potentially could induce.

 

Concerta: no previous medications of these sorts. I started taking them as a way to self-medicate what I thought was ADHD/ADD and to perform better in class. I’m very sensitive to meds generally and a dose of 18 mg concerta has a big effect on me. A friend noticed I would talk really fast. I became really motivated and driven to study, however I became more and more obsessive I guess and I’m not sure exactly what happened but I might have gone into a manic episode (?)

Somewhere along all this chaos I start develop intense anxiety and begin to self medicate with benzodiasapines. I can’t exactly pinpoint what caused me to start taking benzos but i’m guessing it was a combination of high-school pressure, cannabis, concerta and the recent passing of my mother, she died the year before this happened when I started high school and even now after 4 years I sometimes struggle with processing her death.

 

My mothers passing 

In 2013 my mother passed away from Adult T-cell lymphoma caused by a virus HTLV-1. She was a very kind and loving hyper emotional person but suffered episodes of deep depression and according to social services ”delusions which I never noticed. I did however remember one her having some form of persecution paranioa where she would act really scared and cover up the windows with fabric after getting home and having been ”followed” by two guys late at night She’s not diagnosed with any mental illness.

 

I myself was diagnosed with Acute lymphoblastic leukemia successfully treated for two years with various chemotherapies: 6-mercaptopurin, Asparaginas (Erwinia), Cyklofosfamid, Cytarabin, Daunorubicin, Dexametason, Doxorubicin, Methotrexate, Prednisolon, Thioguanin, Vinkristine.No radiation therapy or stem cell transplantation. 

 

I’ve read a little bit about the metabolic theory of cancer, mitochondrial dysfunction and it kinda makes sense. I would really like to know why I had ALL. They say cancer can be genetic or result from a toxin causing mutations and I read somewhere that cancerogenic viruses can be inherited to the infant and that could explain how cancer can be genetic. I’ve read somewhere that HTLC-1 can cause schizophrenia and i’m suspecting it is this virus that was the reason for her cognitive decline leading to symptoms we call ”mental disorder, bipolar or whatnot”. After her death a brain biopsy was made where they found out she had severe brain inflammation. 

 

I’m scared that I have HTLV-1 or some sort of viral infection.I underwent an ELISA-test for HTLV-1 after my mothers passing but tested negative. However, what if it was latent? And also I’ve read that a virus can switch between being latent and active. So would it always be detectable by ELISA? How reliable is even ELISA-test? Can a virus be latent and still cause destruction to cells in the brain e.g? Could a virus-infection be activated from smoking weed? My gut instinct tells me that I do have some form of infection causing alot of my symptoms. Some of my symptoms are actually scaringly similar to my mothers like sometimes I will zone out.

 

Also I’ve been in a S-ketamine trial for a year now starting in july 2016. It helped me alot in terms of depressive relief for the first half year however, I needed to take like 2.5 mg zyprexa and like 0.5 mg xanax to combat the psychotomimetic symptoms caused by it’s strong D2-agonism. So this year I did some research on r-ketamine and eventually got my hands on 1 g of r-ketamine which is ingested intranasally over the course of 40-50 days. And the difference was so huge.

 

I’m tired of this constant fatigue, anxiety, brain fog I have I’ve done everything I could for the past two years to find a cure and this post will probably be one of my last matches in attempt to light a fire. If I can’t find a cure what is the point of living? I’d rather die than being like this, cause right now i’m not going anywhere no matter how hard I try to push myself. I just wanna be happy and free, hangout with my friends and live life to the fullest but I can’t do that in the condition i’m in.


Edited by Mind, 16 August 2017 - 07:32 PM.

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#2 jack black

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Posted 27 July 2017 - 10:23 PM

I couldn't read it all due to this small font hurting my eyes, so maybe i missed some of it.

while the "chemo brain" is the real thing, i'm afraid your problems stem more from your troubled childhood.

as for the why you had ALL (i presume it was pre-B type? when was it? how old are you?), it's mostly bad luck and don't read too much into that. if your HTLV-1 test came back negative, that's it, you don't have to worry about it and i don't see how it's connected to your ALL or current mental issues.

on the other hand, genes are real and you could have inherited some predisposition to mental disease from your mother.

BTW, HTLV-1 is very rare in europe. were your mom an immigrant?


Edited by jack black, 27 July 2017 - 10:25 PM.


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#3 hdl_1

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Posted 27 July 2017 - 10:43 PM

Wow. That's one hell of a story. I thought mine was special lol. I think you may be right with inflamation and you should consider anything that reduces it, along with anything that's immuno modulatory. You should also consider a cure of antibiotics, especially the ones that cross the BBB.

Antipsychotics increase inflamation so this is something you may want to look into.

I only recently started looking into anti inflamatory/immuno modulation since I realised all my symptoms (anxiety, brain fog, blank mind, fatigue, memory issues, +++) may come from this.

I always felt better when taking antibiotics, like my mind was more clear. I always had right side inflamed sinus, but unless I had an infection no one really cared. Finally an ENT decided to do something about it and gave me a prescription of glucocorticoids for nasal rinses. Hold and behold, I'm feeling 10 times better!

You may also want to look into cerebrolysin, which is also a immuno modulator besides its neurogenesis/neuroprotection properties. I just finished 20 injections and it's been by far the best product to get me closer to normal. I droped my supplements/nootropics regimen from several to just fish oil.
I'm now waiting to receive boswella and pine bark to try as anti inflamatories.


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#4 long3vity

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Posted 28 July 2017 - 04:40 PM

I couldn't read it all due to this small font hurting my eyes, so maybe i missed some of it.

while the "chemo brain" is the real thing, i'm afraid your problems stem more from your troubled childhood.

as for the why you had ALL (i presume it was pre-B type? when was it? how old are you?), it's mostly bad luck and don't read too much into that. if your HTLV-1 test came back negative, that's it, you don't have to worry about it and i don't see how it's connected to your ALL or current mental issues.

on the other hand, genes are real and you could have inherited some predisposition to mental disease from your mother.

BTW, HTLV-1 is very rare in europe. were your mom an immigrant?

I know a lot of things from my past has impacted my mental stability profoundly but i'm passed that and I really wanna focus on healing myself. And it doesn't explain why i've been so tired all the time for the most part of my life before all of the above mentioned things happened. I guess it could be long term side-effects from chemotherapy. I actually don't know, what is pre-B type? It was such a long time ago I've requested my journals from the hospital were I was treated for cancer, when I receive them I will check. I was 4 when treated (2001-2003) and i'm 20 now. My mother is not european, she moved here in her 20's


Edited by long3vity, 28 July 2017 - 05:06 PM.

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#5 long3vity

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Posted 28 July 2017 - 05:03 PM

Wow. That's one hell of a story. I thought mine was special lol. I think you may be right with inflamation and you should consider anything that reduces it, along with anything that's immuno modulatory. You should also consider a cure of antibiotics, especially the ones that cross the BBB.

Antipsychotics increase inflamation so this is something you may want to look into.

I only recently started looking into anti inflamatory/immuno modulation since I realised all my symptoms (anxiety, brain fog, blank mind, fatigue, memory issues, +++) may come from this.

I always felt better when taking antibiotics, like my mind was more clear. I always had right side inflamed sinus, but unless I had an infection no one really cared. Finally an ENT decided to do something about it and gave me a prescription of glucocorticoids for nasal rinses. Hold and behold, I'm feeling 10 times better!

You may also want to look into cerebrolysin, which is also a immuno modulator besides its neurogenesis/neuroprotection properties. I just finished 20 injections and it's been by far the best product to get me closer to normal. I droped my supplements/nootropics regimen from several to just fish oil.
I'm now waiting to receive boswella and pine bark to try as anti inflamatories.


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Hey everyone's story is special and unique. Whatever you've been through I hope you've been able to come out stronger from it.

 

Thanks for the tips, I will ask my doctor about antibiotics is there any one in particular you would recommend?

 

I didn't know that about antipsychotics, I hate them anyways as even a low dose for me causes immense tiredness and just bad memory in general. Luckily i've been able to wean slowly myself off the low dose zyprexa i've used nightly in exchange for lithium. I feel like lithium works much better for me in terms of stabilising my mood and and I think it also works for anxiety/paranoia.

 

I've read a little about cerebrolysin and although it sounds promising i'm not sure about injecting myself with pigsbrains-tissue, it just sounds so gross lol but I'm willing to do it if it actually works. I'm glad it worked for you :) Do you know the difference between cerebrolysin and p21?



#6 jack black

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Posted 28 July 2017 - 07:29 PM

 


 

I didn't know that about antipsychotics, I hate them anyways as even a low dose for me causes immense tiredness and just bad memory in general. Luckily i've been able to wean slowly myself off the low dose zyprexa i've used nightly in exchange for lithium. I feel like lithium works much better for me in terms of stabilising my mood and and I think it also works for anxiety/paranoia.

 

 

 

I'm not an expert, but feels like using antipsychotics "to reduce side effects from dexedrine" is not the right thing.

what will happen when (not if) you develop size effect from antipsychotics, will you take more drugs for that?

I agree taking Li sometime in PM should be great. It did improve my life (with the rest of my sizable stack, LOL).



#7 hdl_1

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Posted 28 July 2017 - 08:03 PM



Hey everyone's story is special and unique. Whatever you've been through I hope you've been able to come out stronger from it.

Thanks for the tips, I will ask my doctor about antibiotics is there any one in particular you would recommend?

I didn't know that about antipsychotics, I hate them anyways as even a low dose for me causes immense tiredness and just bad memory in general. Luckily i've been able to wean slowly myself off the low dose zyprexa i've used nightly in exchange for lithium. I feel like lithium works much better for me in terms of stabilising my mood and and I think it also works for anxiety/paranoia.

I've read a little about cerebrolysin and although it sounds promising i'm not sure about injecting myself with pigsbrains-tissue, it just sounds so gross lol but I'm willing to do it if it actually works. I'm glad it worked for you :) Do you know the difference between cerebrolysin and p21?


One of the antibiotics I took that crosses the BBB is Cefuroxime. Asking your doctor for it may be a tough sell. It's not like they'll listen to I just want to try this to see if it makes a difference. Hopefully you can buy it without prescription.

One good anxiolytic that I know of is Mexidol (Emoxypine). Much safer than AP and may actually repair the dopamine pathway.

I actually tried P21 (along with Semax/Selank). It is not comparable to Cerebrolysin. Cerebrolysin got me a good notch closer to normal. I regained depth perception, something I lost like 20 years ago... I also feel more grounded, less in my head. I only hope this lasts. This is my 3rd day after finishing Cerebrolysin.
In any case I already plan buying my 2nd and 3rd round lol. The injections are a pain to do by itself (more psychologically than anything else) but well worth it. :)

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#8 long3vity

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Posted 28 July 2017 - 08:28 PM

 

 


 

I didn't know that about antipsychotics, I hate them anyways as even a low dose for me causes immense tiredness and just bad memory in general. Luckily i've been able to wean slowly myself off the low dose zyprexa i've used nightly in exchange for lithium. I feel like lithium works much better for me in terms of stabilising my mood and and I think it also works for anxiety/paranoia.

 

 

 

I'm not an expert, but feels like using antipsychotics "to reduce side effects from dexedrine" is not the right thing.

what will happen when (not if) you develop size effect from antipsychotics, will you take more drugs for that?

I agree taking Li sometime in PM should be great. It did improve my life (with the rest of my sizable stack, LOL).

 

Yes I know, I was actually prescribed zyprexa for sleep 1 year ago but recently learned that it's not supposed to be used long-term, only for short term treatment of mania/psychosis. I don't know why doctors prescribe it off-label as a sleeping pill when there are other alternatives. I've rarely exceeded 1.25 mg nightly and I've skipped it for night in a row without problem so I think I'll be fine. I'm quitting zyprexa weaning myself off dexedrine, the latter will be a little hard for me I think cause I still struggle with energy even when I take it so I need to fix my tiredness. I might get memantine on prescription from my doctor and if it's remotely similar to r-ketamine I think I'l benefit immensely from it and it would become much easier quitting dexedrine. Apparently memantine is an alpha 7 nicotinic receptor antagonist just like ketamine and it's implicated in mood stabilisation and memory-enhancement



#9 long3vity

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Posted 28 July 2017 - 08:38 PM

 

Hey everyone's story is special and unique. Whatever you've been through I hope you've been able to come out stronger from it.

Thanks for the tips, I will ask my doctor about antibiotics is there any one in particular you would recommend?

I didn't know that about antipsychotics, I hate them anyways as even a low dose for me causes immense tiredness and just bad memory in general. Luckily i've been able to wean slowly myself off the low dose zyprexa i've used nightly in exchange for lithium. I feel like lithium works much better for me in terms of stabilising my mood and and I think it also works for anxiety/paranoia.

I've read a little about cerebrolysin and although it sounds promising i'm not sure about injecting myself with pigsbrains-tissue, it just sounds so gross lol but I'm willing to do it if it actually works. I'm glad it worked for you :) Do you know the difference between cerebrolysin and p21?


One of the antibiotics I took that crosses the BBB is Cefuroxime. Asking your doctor for it may be a tough sell. It's not like they'll listen to I just want to try this to see if it makes a difference. Hopefully you can buy it without prescription.

One good anxiolytic that I know of is Mexidol (Emoxypine). Much safer than AP and may actually repair the dopamine pathway.

I actually tried P21 (along with Semax/Selank). It is not comparable to Cerebrolysin. Cerebrolysin got me a good notch closer to normal. I regained depth perception, something I lost like 20 years ago... I also feel more grounded, less in my head. I only hope this lasts. This is my 3rd day after finishing Cerebrolysin.
In any case I already plan buying my 2nd and 3rd round lol. The injections are a pain to do by itself (more psychologically than anything else) but well worth it. :)

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What improvements did you see with Cefuroxime? Any side-effects? I know antibiotics can be a bit harsh on the body.

 

Repairment of dopamine pathway seems pretty nice! Where can I get mexidol and cerebrolysin? Do you know are reliable source that ships to Sweden?



#10 hdl_1

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Posted 28 July 2017 - 11:45 PM



What improvements did you see with Cefuroxime? Any side-effects? I know antibiotics can be a bit harsh on the body.

Repairment of dopamine pathway seems pretty nice! Where can I get mexidol and cerebrolysin? Do you know are reliable source that ships to Sweden?


I felt more clear minded and less neck tension after Cefuroxime. As far as side effects, there are really none that I experienced.

I buy Cerebrolysin and Mexidol directly from pharmacies (through relatives) both in Russia and Eastern Europe. We wouldn't have the same sourcing in any case since I'm based in North America.

I'm sure there are already some posts here that can help you find a source from Europe.


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#11 long3vity

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Posted 29 July 2017 - 05:22 PM

 

What improvements did you see with Cefuroxime? Any side-effects? I know antibiotics can be a bit harsh on the body.

Repairment of dopamine pathway seems pretty nice! Where can I get mexidol and cerebrolysin? Do you know are reliable source that ships to Sweden?


I felt more clear minded and less neck tension after Cefuroxime. As far as side effects, there are really none that I experienced.

I buy Cerebrolysin and Mexidol directly from pharmacies (through relatives) both in Russia and Eastern Europe. We wouldn't have the same sourcing in any case since I'm based in North America.

I'm sure there are already some posts here that can help you find a source from Europe.


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Okay, I will try to find these substances. Thank you for your insights :)



#12 Zibibbo

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Posted 01 August 2017 - 10:23 AM

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?



#13 Mind_Paralysis

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Posted 01 August 2017 - 10:31 AM

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?

 

Why talk about it AT ALL, when 6-HydroxyNorKetamine is proven to be the REAL therapeutic potential in Ketamine?

 

It's available - and will hopefully soon be more easily obtained.

 

**F*CK** this Mid-Evil magic BULL-sh*t that is classical Ketamine!
 


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#14 Eryximachus

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Posted 04 August 2017 - 05:10 PM

I saw a lot of sob stories in there. Whatever the case, you need a new head doc. 

 

Xanax, Amphetamine, Lithium AND seroquel?  

 

It makes no sense, and with the exception of lithium these are all SERIOUS drugs.  


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#15 long3vity

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Posted 06 August 2017 - 10:43 PM

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?

1) From a source in my country that no longer has it.

2) dosages varied and since I didn't have a proper scale I could only estimate the amount with the help of guidelines I found on the internet. But I did 1 g arketamine intranasally in 1 month so that would be 33 mg everyday. The bioavailability is not that high intranasally but I have to admit that 1 g of arketamine intranasally in 1 month is still way too much and already on the borderline of drug abuse.

 

I do agree with Stinkorninjor about 6-hydroxinorketamine as I've had a MUCH better effect from arketamine than esketamine or racemic ketamine.

From what we know as of know it really seems like it is hydroxinorketamine that is responsible for the strong antidepressant effect of ketamine. 



#16 long3vity

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Posted 06 August 2017 - 11:04 PM

I saw a lot of sob stories in there. Whatever the case, you need a new head doc. 

 

Xanax, Amphetamine, Lithium AND seroquel?  

 

It makes no sense, and with the exception of lithium these are all SERIOUS drugs.  

That wasn't my intention at all. I realise now that I may have written way too much about my childhood and I would like to edit some parts out of my post but I don't know how to edit the post anymore. I chose to write much as possible about my background/growing up because I didn't wanna leave any factors out that could have contributed to my symptoms and I was hoping someone very knowledgable in neuroscience/medicine/psychology here could maybe give me some advice. I felt that I needed to write all of that to increase my chances of getting adequate response. 

 

Listen, I've been through this for a very long time. You don't think I've been through countless of doctors already? What head doctor should I ask for? Yeah, I know they are serious drugs? It's not like I want to take these drugs and that's exactly why I'm here on longecity where I hoped I could find more knowledgable people to get to the root of my problem. as I said earlier, I was diagnosed ADHD-PI, GAD and PTSD what other medicines do you think they will prescribe? I've been through the common ones, believe me. 


Edited by long3vity, 06 August 2017 - 11:23 PM.


#17 jack black

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Posted 07 August 2017 - 03:02 AM

 

as I said earlier, I was diagnosed ADHD-PI, GAD and PTSD what other medicines do you think they will prescribe? I've been through the common ones, believe me. 

 

with the combination of ADHD and GAD, I don't think stimulants are the best way to go. have you tried clonidine (very sedating) or intuniv (little sedation) for ADHD? other non-stimulants or minimal stimulants that can used for ADHD are memantine and adamantine. 

propranolol has a lot of promise in PTSD and may even help you with GAD, look it up. other drugs for GAD to consider are buspar, atarax, ciproheptadine, and even serzone (all 5HT2a antagonists, just like atypical psychotics, but with different actions outside 5HT2a).


Edited by jack black, 07 August 2017 - 03:13 AM.


#18 slackjaw99

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Posted 01 September 2017 - 01:10 AM

Your symptoms are similar to mine, and I was recently diagnosed with a form of PTSD called complex PTSD (cPTSD) and developmental trauma disorder (DTD). This comes after a lifetime of diagnoses describing symptoms such as OCD, SAD, DID, BPD, ADHD, non-24/insomnia, GAD, alcoholism, anhedonia, and depression just to name a few plus attempts to treat said "disorders" (symptoms) with multiple BIG PHARMA drugs, pop-psychology therapies (such as CBT), and drug/alcohol rehabs.

 

cPTSD/DTD are diagnoses that have been rejected by the American DSM (Diagnostic and Statistical Manual ala BIG PSYCHIATRY in cahoots with BIG PHARMA) because they describe the cause not the symptoms, and the more people realize this and get appropriate treatment, the less money BIG PHARMA & PSYCHIATRY stand to make treating and masking symptoms.

 

I'd encourage you to study cPTSD/DTD, and then if you identify, find a developmental trauma informed therapist trained in somatic therapies, look into psychedelic therapies like Ayahuasca, MDMA, and psilocybin (all better than ketamine), high performance neurofeedback (HPN) and deep trans-cranial magnetic stimulation (dTMS). 

 

Trying to chase and suppress symptoms with pharmaceuticals and other chemicals is almost always a losing battle as the underlying problem tends to fester and get worse while tolerance to any given drug develops. An obsession with finding and using chemicals to battle symptoms is indicative of autonomic dysregulation which the brain learns in the first couple years postpartum.

 

 


Edited by slackjaw99, 01 September 2017 - 01:12 AM.

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#19 Zibibbo

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Posted 01 September 2017 - 10:03 AM

 

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?

1) From a source in my country that no longer has it.

2) dosages varied and since I didn't have a proper scale I could only estimate the amount with the help of guidelines I found on the internet. But I did 1 g arketamine intranasally in 1 month so that would be 33 mg everyday. The bioavailability is not that high intranasally but I have to admit that 1 g of arketamine intranasally in 1 month is still way too much and already on the borderline of drug abuse.

 

I do agree with Stinkorninjor about 6-hydroxinorketamine as I've had a MUCH better effect from arketamine than esketamine or racemic ketamine.

From what we know as of know it really seems like it is hydroxinorketamine that is responsible for the strong antidepressant effect of ketamine. 

 

Really interesting.
Did you adviced any psychotomimetic effects or other kind of side effects?
Have you tried strongest dosages but not daily? e.g.: 2-3 times a week.

 

 



#20 Mind_Paralysis

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Posted 01 September 2017 - 02:46 PM

 

I saw a lot of sob stories in there. Whatever the case, you need a new head doc. 

 

Xanax, Amphetamine, Lithium AND seroquel?  

 

It makes no sense, and with the exception of lithium these are all SERIOUS drugs.  

That wasn't my intention at all. I realise now that I may have written way too much about my childhood and I would like to edit some parts out of my post but I don't know how to edit the post anymore. I chose to write much as possible about my background/growing up because I didn't wanna leave any factors out that could have contributed to my symptoms and I was hoping someone very knowledgable in neuroscience/medicine/psychology here could maybe give me some advice. I felt that I needed to write all of that to increase my chances of getting adequate response. 

 

Listen, I've been through this for a very long time. You don't think I've been through countless of doctors already? What head doctor should I ask for? Yeah, I know they are serious drugs? It's not like I want to take these drugs and that's exactly why I'm here on longecity where I hoped I could find more knowledgable people to get to the root of my problem. as I said earlier, I was diagnosed ADHD-PI, GAD and PTSD what other medicines do you think they will prescribe? I've been through the common ones, believe me. 

 

 

UUUNGH!!

 

Massive ADHD-PI symptoms, as a backlash from quitting Intuniv. Head is pounding from compensatory hypertension (caused by Alpha-2a and 5ht2b down-regulation from direct agonisation).

 

I implore you to check out some of the videos of Russell Barkley - he knows a lot about these issues. I also implore you to try these drugs, instead of the ones you're already on:

 

Milnacipran (SNRI's have been proven as more effective towards anxiety than SSRI's and even benzodiazepines in long-term treatment, also, please note, noradrenergic compounds are generally considered more useful for ADHD-PI, or at least a more balanced DA/NE action than ADHD-C needs. Milnacipran is the first truly balanced Serotonin/Noradrenaline compound - bound to be the most useful for someone like you.)

 

Guanfacine (much like propranolol, another blood-pressure regulating compound which affects noradrenergic systems, guanfacine has been proven to lessen activity out of the amygdala, and was under testing for use in the treatment of PTSD - the results were a bit to weak though, BUT...! the drug effects ADHD, which you have - this makes it ideal for you)

 

Modafinil

 

Atomoxetine

 

 

Atomoxetine is often anxiolytic, and once again, it alters noradrenergic systems. Modafinil is also known to cause much less anxiety than classical stimulants, and can be used to combat the fatigue Atomoxetine and Guanfacine causes. However, there is enzymatic interaction between Guanfacine and Modafinil, which makes dosing somewhat tricky, but it can be overcome with careful use and planning.

 

 

 

Small note: noradrenaline is also known as norepinephrine.



#21 long3vity

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Posted 02 September 2017 - 11:58 PM

 

 

as I said earlier, I was diagnosed ADHD-PI, GAD and PTSD what other medicines do you think they will prescribe? I've been through the common ones, believe me. 

 

with the combination of ADHD and GAD, I don't think stimulants are the best way to go. have you tried clonidine (very sedating) or intuniv (little sedation) for ADHD? other non-stimulants or minimal stimulants that can used for ADHD are memantine and adamantine. 

propranolol has a lot of promise in PTSD and may even help you with GAD, look it up. other drugs for GAD to consider are buspar, atarax, ciproheptadine, and even serzone (all 5HT2a antagonists, just like atypical psychotics, but with different actions outside 5HT2a).

 

I don't think so either and right now the only reason i'm taking stimulants is because i'm so fatigued. I've tried to get memantine prescribed for my ADHD-PI or whatever but my doctor is very hesitant because it's indication as an alzheimers medicine. I'll have to see what he says next appointment. I've tried lowest dose intuniv 1 mg xr at night and while it does help anxiety it's only because it is making me so tired (I have already a low blood pressure) and I couldn't possibly take it without stimulants. I would sleep 24/7. Haven't tried propranolol but I've tried atenolol and I know they differ in that atenolol supposedly works on the heart or sth and doesn't cross the BBB like propraponol does? I'll ask my doctor about it. I've tried atarax but not the others. Only made me tired. 



#22 long3vity

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Posted 03 September 2017 - 02:39 AM

Your symptoms are similar to mine, and I was recently diagnosed with a form of PTSD called complex PTSD (cPTSD) and developmental trauma disorder (DTD). This comes after a lifetime of diagnoses describing symptoms such as OCD, SAD, DID, BPD, ADHD, non-24/insomnia, GAD, alcoholism, anhedonia, and depression just to name a few plus attempts to treat said "disorders" (symptoms) with multiple BIG PHARMA drugs, pop-psychology therapies (such as CBT), and drug/alcohol rehabs.

 

cPTSD/DTD are diagnoses that have been rejected by the American DSM (Diagnostic and Statistical Manual ala BIG PSYCHIATRY in cahoots with BIG PHARMA) because they describe the cause not the symptoms, and the more people realize this and get appropriate treatment, the less money BIG PHARMA & PSYCHIATRY stand to make treating and masking symptoms.

 

I'd encourage you to study cPTSD/DTD, and then if you identify, find a developmental trauma informed therapist trained in somatic therapies, look into psychedelic therapies like Ayahuasca, MDMA, and psilocybin (all better than ketamine), high performance neurofeedback (HPN) and deep trans-cranial magnetic stimulation (dTMS). 

 

Trying to chase and suppress symptoms with pharmaceuticals and other chemicals is almost always a losing battle as the underlying problem tends to fester and get worse while tolerance to any given drug develops. An obsession with finding and using chemicals to battle symptoms is indicative of autonomic dysregulation which the brain learns in the first couple years postpartum.

 

Yeah as I said in my first post, i'm already diagnosed PTSD but I don't know exactly in which form but I could certainly have something similar to those that you have.

 

I appreciate your attempt to help me but i've tried MDMA and didn't appreciate it's serotonergic effect (I'm super sensitive to SSRI'S). I tried taking various SSRIS/SNRIS and to even try to titrate up to a therapeutic dose would probably drive me into mania/psychosis. After 4 days on 50 mg Zoloft feelings of derealisation, crystal HD-vision, hyper-focus/mania/bouts of paranoia reminiscent of a too high THC cannabis strain or LSD.

 

Since I was so tired and out of focus at the time of writing my OP, I forgot to mention that I tried a moderate-to-low dose LSD one time with my friend (more than a year ago) who recommended it to me for it's therapeutical effects. Nevertheless, the outcome was disastrous and caused a trauma inside of me so big it affected me for months afterwards. It started with that bizarre HD-vision/hyper-awereness which was nice at the beginning but then it went overboard when I went to the bathroom, washed my hands and looked myself in the mirror. Hyperfocus on my breathing and details of my body. My vision was like batshit crazy microscoping in and out over my whole body and I didn't recognise the person standing in the mirror. I immediately knocked myself out with 1 mg of xanax cause I was so terrified.

 

The following days afterwards I felt weird/not myself, change of perception/hyper-awereness, less inner-monologue and cognitive decline. I was already in a bad state of mind before doing the LSD but it got so much worse. Eventually I couldn't step into a public room without being overwhelmed by all the sensory stimuli. My sense of smell was heightened to such an extreme I don't understand how it's even possible? I could smell everything in a train. It's like that one time I smoked a cigarette in a restaurant and suddenly it was like someone turned the volume up x100 I couldn't even comprehend anything it was just super loud mumbles and sounds of forks etc. 

 

About a week after that LSD I became borderline psychotic. I felt paranoid that my family didn't like me and that's when I realised I had to go to the emergency and so I did and got prescribed zyprexa which took me down. After the LSD trip I started having more derealisation/dissociative symptoms.

 

The only substance that has been close to cure me is ketamine (especially r-ketamine) and I'm certain that it is because of it's ability to restore my cognition. The more you remember and recognise your surroundings and the connection you have to everyone, the less fearful and paranoid you become. That's why people with Alzheimers can become psychotic.  

 

I'm not trying to chase or surpress symptoms with substances. That's what the doctors are doing. If you read my OP you'd understand my symptoms are more than likely caused by inflammation/damage that could be caused by various factors such as viruses, bacteria etc. There's already so much evidence that chronic depression and mental illnesses can be caused by these things (I wouldn't be surprised at all if "can" is a great underestimation). Then it's no wonder that depressed people often have the same symptoms of physically sick people. 


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#23 long3vity

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Posted 03 September 2017 - 02:54 AM

 

 

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?

1) From a source in my country that no longer has it.

2) dosages varied and since I didn't have a proper scale I could only estimate the amount with the help of guidelines I found on the internet. But I did 1 g arketamine intranasally in 1 month so that would be 33 mg everyday. The bioavailability is not that high intranasally but I have to admit that 1 g of arketamine intranasally in 1 month is still way too much and already on the borderline of drug abuse.

 

I do agree with Stinkorninjor about 6-hydroxinorketamine as I've had a MUCH better effect from arketamine than esketamine or racemic ketamine.

From what we know as of know it really seems like it is hydroxinorketamine that is responsible for the strong antidepressant effect of ketamine. 

 

Really interesting.
Did you adviced any psychotomimetic effects or other kind of side effects?
Have you tried strongest dosages but not daily? e.g.: 2-3 times a week.

 

Not nearly as much as s-ketamines psychotomimetic effects. More like your in a dazed of dreamy state of mind for a while, just very relaxed and zen like, sometimes old nostalgic memories popping up that you almost forgot existed but recognise instantly as they become retrievable. Side effects wise I think I should have dosed less frequently (no less than 3 days apart) cause tolerance increases scaredly fast and even if you dose higher to achieve the same antidepressant effect as in the beginning, you'll end up with more side effects because of the higher dissociative effect.



#24 Eryximachus

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Posted 03 September 2017 - 01:10 PM

Friend, you were just hospitalized for psychosis. 

 

The randomness of your writings, the absurd cocktail of drugs you are taking... I could go on.  But, more than like you are schizophrenic.   You need to get off the amphetamines, LSD, and every other drug structurally related to adrenaline. You need to stop taking xanax, which is so short acting you are undoubtedly going into withdrawals periodically. What is benzo withdrawal like? It's just like taking amphetamine.  

 

You need to be on 600mg of seroquel at minimum, and you need to stay on that and just that for several months.

 

As it stands, how can anyone help you?  Is there any drug you haven't tried since you started writing this thread?

 

You want to figure this out, I get it.  You're fascinated by all of these potential causes, PTSD, infectious diseases, etc.   But all of the theories you have mentioned are very poorly understood.  I mean, it's been just a few years since toxoplasmosis was isolated as a major cause of, you guessed it, schizophrenia.  

 

As it stands, you need to get your head on straight, and Seroquel is what you need to be on.  And at doses 10 times higher than what you're on right now.  

 

 


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#25 Zibibbo

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Posted 03 September 2017 - 04:48 PM

 

 

 

Let's talk about R-ketamine.

 

1) where did u find the R isomer?

2) wich dosages did u use? wich route of administration?

1) From a source in my country that no longer has it.

2) dosages varied and since I didn't have a proper scale I could only estimate the amount with the help of guidelines I found on the internet. But I did 1 g arketamine intranasally in 1 month so that would be 33 mg everyday. The bioavailability is not that high intranasally but I have to admit that 1 g of arketamine intranasally in 1 month is still way too much and already on the borderline of drug abuse.

 

I do agree with Stinkorninjor about 6-hydroxinorketamine as I've had a MUCH better effect from arketamine than esketamine or racemic ketamine.

From what we know as of know it really seems like it is hydroxinorketamine that is responsible for the strong antidepressant effect of ketamine. 

 

Really interesting.
Did you adviced any psychotomimetic effects or other kind of side effects?
Have you tried strongest dosages but not daily? e.g.: 2-3 times a week.

 

Not nearly as much as s-ketamines psychotomimetic effects. More like your in a dazed of dreamy state of mind for a while, just very relaxed and zen like, sometimes old nostalgic memories popping up that you almost forgot existed but recognise instantly as they become retrievable. Side effects wise I think I should have dosed less frequently (no less than 3 days apart) cause tolerance increases scaredly fast and even if you dose higher to achieve the same antidepressant effect as in the beginning, you'll end up with more side effects because of the higher dissociative effect.

Wanna you write apart a well described thread over you entire experience?



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#26 long3vity

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Posted 03 September 2017 - 05:41 PM

 

 

I saw a lot of sob stories in there. Whatever the case, you need a new head doc. 

 

Xanax, Amphetamine, Lithium AND seroquel?  

 

It makes no sense, and with the exception of lithium these are all SERIOUS drugs.  

That wasn't my intention at all. I realise now that I may have written way too much about my childhood and I would like to edit some parts out of my post but I don't know how to edit the post anymore. I chose to write much as possible about my background/growing up because I didn't wanna leave any factors out that could have contributed to my symptoms and I was hoping someone very knowledgable in neuroscience/medicine/psychology here could maybe give me some advice. I felt that I needed to write all of that to increase my chances of getting adequate response. 

 

Listen, I've been through this for a very long time. You don't think I've been through countless of doctors already? What head doctor should I ask for? Yeah, I know they are serious drugs? It's not like I want to take these drugs and that's exactly why I'm here on longecity where I hoped I could find more knowledgable people to get to the root of my problem. as I said earlier, I was diagnosed ADHD-PI, GAD and PTSD what other medicines do you think they will prescribe? I've been through the common ones, believe me. 

 

 

UUUNGH!!

 

Massive ADHD-PI symptoms, as a backlash from quitting Intuniv. Head is pounding from compensatory hypertension (caused by Alpha-2a and 5ht2b down-regulation from direct agonisation).

 

I implore you to check out some of the videos of Russell Barkley - he knows a lot about these issues. I also implore you to try these drugs, instead of the ones you're already on:

 

Milnacipran (SNRI's have been proven as more effective towards anxiety than SSRI's and even benzodiazepines in long-term treatment, also, please note, noradrenergic compounds are generally considered more useful for ADHD-PI, or at least a more balanced DA/NE action than ADHD-C needs. Milnacipran is the first truly balanced Serotonin/Noradrenaline compound - bound to be the most useful for someone like you.)

 

Guanfacine (much like propranolol, another blood-pressure regulating compound which affects noradrenergic systems, guanfacine has been proven to lessen activity out of the amygdala, and was under testing for use in the treatment of PTSD - the results were a bit to weak though, BUT...! the drug effects ADHD, which you have - this makes it ideal for you)

 

Modafinil

 

Atomoxetine

 

 

Atomoxetine is often anxiolytic, and once again, it alters noradrenergic systems. Modafinil is also known to cause much less anxiety than classical stimulants, and can be used to combat the fatigue Atomoxetine and Guanfacine causes. However, there is enzymatic interaction between Guanfacine and Modafinil, which makes dosing somewhat tricky, but it can be overcome with careful use and planning.

 

 

 

Small note: noradrenaline is also known as norepinephrine.

 

Why did you quit Intuniv? I'm a bit scared of SNRI's due to how I respond to SSRI'S 

 

I'm gonna check out Russel Barkley's lectures, thanks!

 

You are absolutely right about noradrenergic compounds being more useful for ADHD-PI. I've tried both Ritalin (NDRI) and Atomoxetine/Strattera and they both give me a much better working memory and overall ability to retain information, the only problem is that they cause adverse side effects. From Ritalin I get too anxious/frozen and OCD-ish and Strattera gave me morbid depressive thoughts and huge mood swings to the point I started become suicidal and also on edge and a bit anxious like Ritalin.

 

I'd like to try modafinil to keep me awake instead of taking dexedrine so i'm gonna ask my doctor for it. 

 

But what i'm really trying to do now is fixing my iron deficiency and getting my B-12 levels up. My ferritin levels are ridiculously low and I don't know why but i'm supplementing with lot's of iron rich food and pills right now so hopefully it will make me more alert.







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