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Sirtuins sense NAD+, but neither NADH nor the ratio

sirtuins nad+

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#1 stefan_001

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Posted 28 September 2017 - 08:38 PM


In particular, we focus on the sirtuin family and assess the current evidence that the sirtuin enzymes sense these dinucleotides and discuss the biological conditions under which this might occur; we conclude that sirtuins sense NAD+, but neither NADH nor the ratio.

http://www.sciencedi...005272817301457

 

As some of us suspected. More support for NAD+ boosting.


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#2 mrkosh1

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Posted 29 September 2017 - 02:25 AM

Interesting. If the SIRT genes do not sense a change in the NAD+ to NADH ratio, what does? 

 

Does PARP notice a change?

 

Does AMPK notice a change? 

 

Does some other gene notice a change? 



#3 MikeDC

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Posted 30 September 2017 - 02:10 AM

Interesting. If the SIRT genes do not sense a change in the NAD+ to NADH ratio, what does?

Does PARP notice a change?

Does AMPK notice a change?

Does some other gene notice a change?


The notion that only the ratio matters is against chemistry and physics. you can have a potential for a reaction, but without reactants nothing will happen.
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#4 mrkosh1

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Posted 30 September 2017 - 03:59 AM

I don't think only ratio matters, but I think that it should be able to be sensed by various genetic pathways. 







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