I speculated before that NAD+ may up regulate another anti aging gene Klotho. A new human study showed that inflammation reduces klotho expression. We know inflammation down regulate NAD+ and Sirt1. So either NAD+ directly up regulate Klotho or through Sirt1. https://www.ncbi.nlm...i=1&from=klotho
#1
Posted 02 October 2017 - 10:52 PM
I speculated before that NAD+ may up regulate another anti aging gene Klotho. A new human study showed that inflammation reduces klotho expression. We know inflammation down regulate NAD+ and Sirt1. So either NAD+ directly up regulate Klotho or through Sirt1. https://www.ncbi.nlm...i=1&from=klotho
#2
Posted 03 October 2017 - 02:10 PM
But is there any evidence that increasing NAD+ upregulates Klotho?
#3
Posted 03 October 2017 - 03:23 PM
It is a theory now. We know NMN down regulate NAMPT and inflammation. Lower inflammation should up regulate Kloth. The logic is there. Just need to have direct experimental data.
#4
Posted 04 October 2017 - 10:24 PM
1. That study linked says nothing about NAD+
2. How can a thread starter be off topic with the first post?
#5
Posted 04 October 2017 - 11:38 PM
So inflammation down regulate NAD+, Sirt1, and Klotho. NAD+ down regulate inflammation. There is an positive correlation between NAD+
And Klotho.
I am interested in this because I want to know if NR can take care of Klotho so we don't need to look
For Klotho supplements.
#6
Posted 06 October 2017 - 12:28 PM
> I am interested in this because I want to know if NR can take care of Klotho so we don't need to look
For Klotho supplements.
Are there any klotho supplements?
#7
Posted 06 October 2017 - 01:11 PM
http://www.longecity...upplementation/
#8
Posted 06 October 2017 - 02:47 PM
My opinion is there is no kolotho supplement right now that can go beyond what NR can do. It may never happen if klotho is regulated by NAD+ and Sirt1. Here is the thread on klotho supplements.
http://www.longecity...upplementation/
With all due respect Mike, you haven't shown that NR upregulates klotho. What you've shown is that inflammation down regulates klotho and that NR down regulates inflammation to some extent. I like where your chain of causality is going, but it is a chain and not direct causation.
And, what we'd like to see is klotho upregulated to the extent people with favorable genes are upregulated, in other words klotho levels beyond what their genome might normally produce.
And any any case, we can make your argument for anything that down regulates inflammation. Of all the positive things that NR may do, I don't get the impression that it is the strongest anti-inflammatory agent we have on the shelf.
#9
Posted 06 October 2017 - 03:39 PM
#10
Posted 06 October 2017 - 03:44 PM
Can't argue with the above.
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