7 replies to this topic

[eighthman]

http://www.lifecoder...rease-lifespan/

 

The above is a WTF moment. Very frustrating to run into stuff that appears to contradict our hopes.

 

Any ideas on what's going on here?

[APBT]

FULL TEXT:

 

Attached Files

•  Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans.pdf   577.05KB   9 downloads

[Freebytes]

This does not state that autophagy is bad or unnecessary. Instead, it is saying that malfunctioning autophagy is worse than not having it at all.

This is like having a five man team on a basketball court, and one of them is a star player; however, he gets tired and injured so is no longer good for the second half, but the coach keeps him on the court anyway. Five strong players are still best, but four players would be better than having some extra guy out there missing all of the shots and getting the ball stolen.

Autophagy may still be effective, but malfunctioning autophagy mechanisms do more harm than good, and it may not be autophagy to blame at all. The same genes may be encoding for something unrelated but still negative when reaching old age.

Edited by Freebytes, 16 October 2017 - 02:17 AM.

[eighthman]

The last sentence of the introduction ("we propose") says that autophagy switches to harmful. How this fits in with other studies showing benefits, I don't know.

[eighthman]

https://sputniknews....o-reduce-aging/

 

This just popped up.  Goes in the opposite direction as pro-autophagy.  

[Freebytes]

Yes, I read that. I think you may be confused by the double negatives in the explanation in the actual report. They state that KLF deficiency is negative and abundance is positive. KLF increases autophagy. All instances state the efficient autophagy is positive for longevity. The only time autophagy is negative is when it is malfunctioning, and that autophagy pathway malfunctioning leads to aging.

To summarize, the neuronal autophagy inhibition resulted in increased lifespan only because it deactivated a malfunctioning autophagy system. This new report indicates that a well functioning autophagy system extends lifespan as originally suggested from all previous studies.

[eighthman]

I understand what you're saying but would like greater details as to how this malfunctioning autophagy is taking place.  Do vesicles/inclusions form but are not broken down or expelled?  We need to see what part of the process is missing.

 

Me, I'm doing enteric trehalose, autophagy-wise.

[SearchHorizon]

The research paper is in line with others indicating that many anti-aging mechanisms in an organism malfunction as as the organism ages, and that the malfunctioning of those mechanisms themselves contribute to the overall senescence of the organism.

 

To me, this research paper reinforces the idea that age-related breakdowns don't occur in just ONE or TWO links in a larger chain of the cell-cycling process (i.e., a cell's deterioration, its malfunction, its removal, and its replenishment), but in ALL of the links simultaneously. So, for example, an effort to address just stem cell proliferation will not work as an anti-aging cure - we'd still have problems with other aspects of aging (such as removing malfunctioning cells).

 

That multiple links in the cell cycling process break down with aging - this idea suggests that the overall senescence is triggered by something more upstream. There is probably something, as basic and fundamental as NAD+ metabolism, that scientists have not yet  discovered.