7 replies to this topic

[Qwertyuiop]

Recently after ONE dose of 0.25 mg Bremelanotide about 2 months ago, I have ended up with anhedonia. Its spiraling out of control

 

In the first few days it was getting better, then randomly got worse and then better again but I was left with a blank mind. Then the flatness randomly came back. Sometimes it isn't as strong but I am still blank minded. Now its just gotten worse though.

 

Hard to even get through a day.

 

I've tried Ketamine Infusions but they hardly helped maybe a bit. Had 6 of em

 

Other stuff I've tried: Selank (helped a little maybe), Modafinal (did not really help), Ritalin (numbed more), Buspar (numbed more), Guanfacine (does nothing)

 

What other things should I look into?

 

I've heard stuff about Kappa agonism.

 

Could a cycle of GHB potentially reset this as well? Deep sleep for 1-2 weeks with Xyrem for example to let the body heal and come back to homeostasis?

 

This is a living nightmare for me. Feels like my future is totally destroyed. I was normal mentally prior to the Bremelanotide.

Edited by Qwertyuiop, 24 December 2017 - 04:21 AM.

[Qwertyuiop]

Bump

Any ideas?

Prior to Bremelanotide I had was fine. It was anhedonia overnight. Was just achieving my dreams and did not have stress at the time. Any stress I had was eustress.

[three_wave]

I have been interested in pt-141 for awhile now but I keep reading experiences like yours. They seem to be random, but quite extreme. It sounds like your experience is typical when this happens. Things improve for a time then begin to fluctuate, never fully recovering.

What intrigues me is that this is currently in phase 3 trials and pending fda approval to be marketed as "Vyleesi", a drug to treat female sexual dysfunction. Apparently in earlier trials 80% of women opted to continue using it. Sounds very effective but what happened to the 20% though?

Do you have any developments? Have things improved at all?

[gamesguru]

May I ask your age?  Your stress levels?  Previous history of illness?  It is rare for a substance to induce an illness which the afflicted would not have later developed anyways.  The risk however becomes more real when you stack multiple substances, as you have done quite desperately.

 

this is likely the result of downregulated melanocortin receptors in the nucleus accumbens, the brain's reward center.

 

 

we don't currently have a way of reversing this.  please don't try more ketamine or get any bright ideas with the opioid system.  instead reduce your stress levels and wait out the storm

[REBUILDER]

I have no personal experience with this or any knowledge about it, but it looks to me like https://www.reddit.c...donia_Recovery/ is probably the best resource available for this problem.

 

Sarcosine and NAC... have very little side effects, if any! (most people get absolutely none). Here are testimonials from people who had anhedonia as a negative symptom of schizophrenia, anhedonia from accutane, and anhedonia from depression...

..
Sarcosine + NAC (n-acetylcysteine) Success Stories for Anhedonia
 
And here's a google doc:
DMG vs. Sarcosine

Edited by REBUILDER, 14 November 2018 - 05:45 AM.

[sant2060]

You say you were fine prior to Bremelantoide...but, it begs one question; why were you trying experimental injectable libido drug if everything was fine?

Seems to me that at least you had libido issues. Which can point to some other issues.

[three_wave]

I just realized that several of the other posts I'd been reading are from the same guy (same doseage and writing style, and in one instance a nearly identical user name). Perhaps this isn't as widespread as I thought, but still how could this happen?

 

Are these your posts?

 

https://www.reddit.c...cal_depression/

https://www.reddit.c...uced_anhedonia/

https://www.depressi...e-me-anhedonia/

[gamesguru]

does seem like the same guy.

 

NAC and sarcosine target it through glutamate, this guy might have caused it by another route.  He already tried ketamine too