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Pancreatic cancer - Supplementation? Promissing treatment?

cancer pancreatic resveratrol curcumin promissing treatment

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#1 gomesbs

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Posted 14 January 2018 - 12:59 PM


Hi,

 

My mother just got diagnosed with cancer in the head of pancreas. Prognostic is not good usually for this type of cancer.

 

The cancer seems to be localized in the pancreas (though we never know) so the docs most likelly will go for chemotherapy and after evaluate resection option.

 

I've been researching supplementation that could help, and came up with resveratrol/ptero and curcumin.

The interaction with chemotherapy seems to help effectiveness, but I don't want to mess with her treatment, since I'm no doctor and reading studies like the link below makes me think if I would not be fueling cancer instead of helping fight it:

 

https://www.salk.edu...-key-nutrients/

 

Do you think there are supplements that can help? Or lifestyle behaviours?

 

Also, do you know of any promissing treatment that I should keep an eye on?

 

Thanks!

Bruno



#2 sensei

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Posted 14 January 2018 - 04:07 PM

Yes!

 

Intravenous and Liposomal Vitamin C. COMBINED

 

The George Washington University Center for Integrative Medicine offers it as adjunctive therapy.

 

The vitamin C becomes a pro-oxidant at such high doses and creates so much H202 that cancer cells (that suck at producing catalase) die from oxidative stress.



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#3 sensei

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Posted 14 January 2018 - 05:15 PM

ASCORBATE INDUCES AUTOPHAGY IN PANCREATIC CANCER

 

Pharmacological ascorbate selectively kills some cancer cell types including pancreatic cancer. Cell death is dependent on H2O2 formation. H2O2 generation is dependent on ascorbate concentration and incubation time, and displays a linear relationship with ascorbate radical formation, ascorbate being the electron-donor. Thus, pharmacological ascorbate concentrations produce extracellular H2O2, which diffuses into cells causing cell death via oxidative stress. The role of autophagy in cellular responses to oxidative stress is as yet unclear. Reactive oxygen species (ROS), like H2O2, can induce autophagy, which may contribute to cell death. In contrast, autophagy may play a protective role of in ROS-mediated necrosis.

 

 

https://www.ncbi.nlm...les/PMC2859094/



#4 sensei

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Posted 14 January 2018 - 05:17 PM

Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy.

 

The present study investigates the anticancer effect of ascorbate in MIA-PaCa-2 human pancreatic cancer cells using both in vitro and in vivo models, with a focus on assessing the role of oxidative stress and autophagy as important mechanistic elements in its anticancer actions. We showed that ascorbate suppresses the growth of human pancreatic cancer cells via the induction of oxidative stress and caspase-independent cell death. Ascorbate induces the formation of autophagosomes and the presence of autophagy inhibitors suppresses ascorbate-induced cell death. These data suggest that the induction of autophagosome formation contributes to ascorbate-induced pancreatic cancer cell death.

 

https://www.ncbi.nlm...pubmed/26132849



#5 gomesbs

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Posted 15 January 2018 - 08:20 PM

Thanks Sensei!

 

Seems promissing. I asked my mother's oncologist and he doesn't oppose so we will probably give it a try.

 

I'm researching what liposomal  formulation proveides the best value for money.

 

Bruno



#6 HaplogroupW

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Posted 15 January 2018 - 10:50 PM

Another thing to look into is fasting or fasting-mimicking-diet that Valter Longo has studied at USC as adjuvant cancer therapy:

https://news.usc.edu...against-cancer/

 

Earlier study showed it reduced or eliminated chemo side-effects:

https://www.ncbi.nlm...les/PMC2815756/

 

I think part of the theory behind depends on "differential stress resistant": normal healthy cells are able to inhibit mTOR, upregulate autophagy, and go into a "protective" mode under nutrient starvation conditions, but cancer cells don't do that (as well?):

http://europepmc.org...cles/pmc2448817

 

 



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#7 gomesbs

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Posted 16 January 2018 - 11:44 AM

Thanks for the help HaplogroupW!

 

She will go on to chemotherapy with folfirinox which is very toxic, and I worry that she'll have trouble eating and fasting may not help keep a healthy weight.

 

Nevertheless, maybe the reasoning you've sent supports the use of Resv/Ptero since they probably mimicck some of the caloric restriction effects.

 

Thanks!

 

Bruno

   

#8 HaplogroupW

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Posted 16 January 2018 - 06:56 PM

If I understand correctly, protection of healthy cells from toxicity of the chemo is an important benefit. The cells need to be in a nutrient-starved environment to produce the desired effect; it is unlikely adding a supplement on top of normal caloric intake is going to produce the desired effect.

 

This is possibly useful:

References to the literature appear at the end of the video.



#9 sensei

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Posted 16 January 2018 - 10:21 PM

Thanks Sensei!

 

Seems promissing. I asked my mother's oncologist and he doesn't oppose so we will probably give it a try.

 

I'm researching what liposomal  formulation proveides the best value for money.

 

Bruno

 

Liposomal -- Mercola worked best for me, as long as your mother can still swallow.   

 

https://www.amazon.c...0?ie=UTF8&psc=1

 

 

 

Talk to the oncologist RE: IV formulation of ascorbate -- Fred Klenner and Robert Cathcart (both MDs) did much of the groundbreaking work using C for almost everything at doses up to 200 grams a day

 

here is a link to the formulations

 

http://www.doctoryou...ennerpaper.html

 

http://www.doctoryou...com/vitciv.html


Edited by sensei, 16 January 2018 - 10:22 PM.


#10 Moumou

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Posted 18 January 2018 - 06:42 AM

Punicic Acid & Ellagic Acid in Pomegrenate

 

https://www.ncbi.nlm...pubmed/21868510

 

https://digitalcommo...ch/vol1/iss2/7/

 

http://ar.iiarjourna.../31/9/2699.full

 

https://www.ncbi.nlm...les/PMC5355345/



#11 gomesbs

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Posted 18 January 2018 - 05:06 PM

Thanks HaplogroupW, the idea with resv was to mimic caloric restriction, I know it isn't the same thing but maybe it helps.

 

Thanks Sensei, I ordered this one: https://www.amazon.c...l/dp/B0087HW65K

Mercola had some bad reviews due to not being truly liposomal but maybe it works too... regarding the IV VitC I will approach the oncologist but I will not push it since it's not standard treatment and I don't even know if he can prescribe it.

 

Moumou, thanks for the help, as I don't want to stuff her up in too many pills I already told her to include pomegranate juice in her diet.

 

 

 

 



#12 sensei

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Posted 19 January 2018 - 06:21 PM

Thanks HaplogroupW, the idea with resv was to mimic caloric restriction, I know it isn't the same thing but maybe it helps.
 
Thanks Sensei, I ordered this one: https://www.amazon.c...l/dp/B0087HW65K
Mercola had some bad reviews due to not being truly liposomal


I took 12 grams of the mercola capsules at one time on an empty stomach -- no GI distress.

If they were not liposomal - i would have been running to the can.

#13 Astroid

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Posted 20 January 2018 - 07:52 AM

Search - Low Dose Naltrexone + Pancreatic Cancer.
  • Informative x 1

#14 Astroid

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Posted 20 January 2018 - 07:52 AM

Search - Low Dose Naltrexone + Pancreatic Cancer.

#15 Francesco Calderone

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Posted 20 January 2018 - 08:39 PM

I am writing you some links on an excerpt that has produced extraordinary results in the fight against cancer that can be useful to you:

https://www.cancertu...aurose-extract/

http://www.sutherlandiaopc.com/

http://www.tbyil.com/oleander1.htm

http://www.tbyil.com/oleander3.htm

With best wishes for a speedy recovery!

I forgot this: Attached File  Clinical Studies OPC Plus Laurose Extract_13gen18.pdf   558.39KB   991 downloads


Edited by Francesco Calderone, 20 January 2018 - 08:45 PM.


#16 Astroid

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Posted 22 January 2018 - 06:34 AM

I remember one article by the Gov't Research MD who originally used LDN for Cancer.. and AIDs.. they kept 50% of terminal cancer patients alive.  Originally they only used terminal patients.  

 

They did cure Pancreatic cancer in people with LDN ! 

 

Which they said was one of the hardest to treat. 

 

Also.. LDN can be used with any other Cancer Treatment.. from what I have read. 

Pancreatic cancer 



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#17 gomesbs

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Posted 22 January 2018 - 09:42 AM

Hi Francesco, thanks for the links. For now we'll be following the conventional route, maybe if it doesn't work we'll try other approach.

 

Regarding LDN, there's not much scientific info on that but I'll keep googling.

 

I've read also about paricalcitrol which can help chemo get to the tumor, there are some trials going on. Does anyone have an opinion/experience with it?

 

Thanks!

Bruno







Also tagged with one or more of these keywords: cancer, pancreatic, resveratrol, curcumin, promissing treatment

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