As if you needed another reason to take Ortho-Core over any other multivitamin... here's another:
J Nutr. 2006 Feb;136(2):390-6.
Pyrroloquinoline quinone modulates mitochondrial quantity and function
in mice.
Stites T, Storms D, Bauerly K, Mah J, Harris C, Fascetti A, Rogers Q,
Tchaparian E, Satre M, Rucker RB.
Department of Nutrition (College of Agriculture and Environmental
Sciences), Los Angeles, CA 90089, USA.
When pyrroloquinoline quinone (PQQ) is added to an amino acid-based,
but otherwise nutritionally complete basal diet, it improves
growth-related variables in young mice. We examined PQQ and
mitochondrial function based on observations that PQQ deficiency
results in elevated plasma glucose concentrations in young mice, and
PQQ addition stimulates mitochondrial complex 1 activity in vitro.
PQQ-deficient weanling mice had a 20-30% reduction in the relative
amount of mitochondria in liver; lower respiratory control ratios, and
lower respiratory quotients than PQQ-supplemented mice (2 mg PQQ/kg
diet). In mice from dams fed a conventional laboratory diet, but
switched at weaning to the basal diet, plasma glucose, Ala, Gly, and
Ser concentrations were elevated at 4 wk (PQQ- vs. PQQ+), but not at 8
wk. The relative mitochondrial content (ratio of mtDNA to nuclear DNA)
also tended (P<0.18) to be lower (PQQ- vs. PQQ+) at 4 wk, but not at 8
wk. PQQ also counters the mitochondrial complex 1 inhibitor,
diphenylene iodonium (DPI). Mice were gavaged with 0, 0.4, or 4 microg
PQQ/g body weight (BW) daily for 14 d. At each PQQ level, DPI was
injected (i.p.) at 0, 0.4, 0.8, or 1.6 microg DPI/g BW. The
PQQ-deficient mice exposed to 0.4 or 4.0 microg DPI/g lost weight and
had lower plasma glucose levels than PQQ-supplemented mice (P<0.05). In
addition, fibroblasts took up (3)H-PQQ added to cell cultures, and
cultured hepatocytes maintained mitochondrial PQQ concentrations
similar to those observed in vivo. Collectively, these results indicate
that dietary PQQ can influence mitochondrial amount and function,
particularly in perinatal and weanling mice.
PMID: 16424117 [PubMed - in process]
