LONGECITY

If any of you haven't seen or heard about topical DMAE, it's what is called "face-lift in a jar". Basically, it fills and swells fibroblasts, creating a firmer, more lifted look. However, a study showed that it has a 25% fibroblast mortality rate within 24 hours of application.
http://onlinelibrary...7681.x/abstract

At the same time, it is argued that this killing of fibroblasts is similar to Retin-A, i.e. long-term, it proves to be a skin-saver. One study shows improvement in facial firmness after 8 weeks of use.
http://www.ncbi.nlm....pubmed/20095140

I have yet to hear from long-term DMAE users what their experience has been. Does anyone here have any personal experience of long-term topical DMAE use? Dr. Perricone is the one who has pushed this ingredient the most in his products, in case any of you has used his line.

Cheers!

Where do you see the 25% fibroblast stat in the abstract? That swelling the individual cells would result in an improved look makes sense but the mortality angle is interesting. From wikipedia - "Tissue damage stimulates fibrocytes and induces the mitosis of fibroblasts." Chemical peels seem to oblige the skin to accelerate turnover so perhaps DMAE causes generation of new fibroblasts?

That's a tough theory though.. According to this study DMAE "reduced the proliferation of fibroblasts."

The conclusion in the abstract that the "vacuolar cytopathology" causes the improvement in skin characteristics is a head scratcher. One doesn't like to read "pathology" as a side effect of any treatment.

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Didn't DMAE cause apoptotic cell death through osmosis or something? I think the study was done on rabbits but I cant find it.

Where do you see the 25% fibroblast stat in the abstract? That swelling the individual cells would result in an improved look makes sense but the mortality angle is interesting. From wikipedia- "Tissue damage stimulates fibrocytes and induces the mitosis of fibroblasts." Chemical peels seem to oblige the skin to accelerate turnover so perhaps DMAE causes generation of new fibroblasts?

That's a tough theory though.. According to this study DMAE "reduced the proliferation of fibroblasts."

The conclusion in the abstract that the "vacuolar cytopathology" causes the improvement in skin characteristics is a head scratcher. One doesn't like to read "pathology" as a side effect of any treatment.

The 25% I found from other sources:
http://www.eurekaler...l-acc041107.php

Didn't DMAE cause apoptotic cell death through osmosis or something? I think the study was done on rabbits but I cant find it.

Not sure about the osmosis part but did you check the first study I posted?

Does anyone know if topical DMAE can produce systemic side effects?  I had a bad reaction to centrophenoxine, which seems similar to DMAE, but I want to use it topically for it's firming effects.