Longecity Blog

win$100 for 'best regimen'

Fri, 09 Jun 2017 09:08:00 +0000

The forum structure at the heart of LongeCity works well in facilitating a free flow of communication and information exchange.
Other more structured ways of curating information have their own advantages, but their adoption appears to be more difficult.

In 2014 we closed the 'regimen' forums for brain enhancement and general supplements in favour of a new 'stacks' function.
aiming to generating a searchable database of combinations as an easily accessible resource.

It took some time for the new feature to gain traction. In some areas this worked ok, in others we still don't have any entries.

To further promote the feature we are launching a small COMPETITION for the BEST REGIMEN in each category.

On Sept.1st LongeCity leadership will draw up a shortlist of the most promising entries for each existing category:

Life Extension, General Health;
Alertness, Cognition, Mood
Sports, Performance, Bodybuilding
Medical
Weight Loss
Beauty, Cosmetics, Skin, Anti-Aging

This shortlist will be based (but not necessarily bound) by the average of the "star ratings" an entry has received from all LongeCity readers!
The Immortality Institute Members will then vote on a winner from each shortlist
The winner in each category* will receive $100 (via paypal) and ₮100.

(* yes, that means that the winning chance in the currently empty, or sparsely populated categories might be higher)

At least for the duration of the competition, the old 'stacks' forums will re-open. We hope that by now everyone has understood the distinction we are aiming for: the 'regimen' feature is for presenting and discussing structured regimens that can be considered, compared and potentially adopted by others down the ages, the forums are for more free-wheeling conversation that might be more speculative, protracted and less likely to hold a swift take-away message for others.

CellAge fundraiser support

Sat, 28 Jan 2017 23:16:00 +0000

UPDATE Feb.9th 2017: success!

LongeCity.Org has decided to support the current CellAge Fundraiser initiative beyond its standard support for certified ‘star-rated’ community fundraiser through an extension of its affiliate lab programme. To this end we have identified a specific small ‘sub goal’ within the first work project of the CellAge programme to get behind:

The LongeCity-supported sub-goal:
The first 'work project' of the CellAge fundraiser is to design candidate synthetic promoters which would be able to accurately detect senescent cells. One of the very first scientific steps is to analyse transcription profiles of senescent cells. The team plans to cover different senescence states, in cells from different tissues and at different stage of senescence.
The LongeCity target fund is raised in support of achieving one variant of this initial sub-goal: to ascertain the unique RNA profile of induced senescence in human fibroblasts.

EXCURSE:

Why RNA profile? – this will not only allow the group to design their promoters, for the rest of the project but could also be useful to other groups working on aging research looking for a unique ‘aging signature’. This research will be publicly disseminated under the CellSense theme and potentially benefit other researchers across the globe.

Why human fibroblasts? – Fibroblast are cells that have an important role in connective tissue formation, including the formation of extracellular matrix and collagen, they play an important role in wound healing. For better or worse this cells are ubiquitous in aging research and can be obtained relatively easily as fresh biopsy samples and from cell lines. Using these cells will mean that the results are more likely to be relevant.

Why induced senescence? There is ‘replicative’ senescence where cells are grown until they stop dividing. This takes a while and may not be that important to why humans die of aging. Induced senescence comes in two forms: deliberate switching off of certain genes and triggering senescence in a roundabout way by causing specific damage to the cell. These measures may be quite a better simulation as to how damage leads to aging in humans.

By clearly defining the boundaries of this sub-goal we can be assured that contributions made towards it are directly impactful. In fact, even if the whole project should need some more time to develop, just this sub-goal alone might be a valuable contribution to anti-aging research. At the same time all the data generated in the sub-goal is directly integral to the larger whole of the project.

LongeCity has committed to match $3000 worth of donations specifically in support of this sub-goal. Priority will be given to donations made through the LongeCity site ⇒ HERE, prior to February 18th.

(NOTE (UPDATED!): when donating to this sub-goal via LongeCity, your details (name & email) will be shared with lifespan.io, so you can be eligible for the lifespan.io rewards. If you do not wish for your details to be shared in this manner and opt out of the lifespan.io rewards please indicate this in the note with your donation or ⇒ contact us, with full details and reference to your donation.)

LongeCity Newsletter April 2014

Fri, 18 Apr 2014 23:14:00 +0000

link: http://www.longecity.org/newsletter/LongeCityNewsletter_2014_04.htm

LongeCity forum upgrade

Mon, 07 Apr 2014 22:41:00 +0000

http://www.longecity.org/forum/topic/69811-forum-upgrade-april-2014/

LongeCity Guest Editors sought

Sun, 09 Mar 2014 21:12:00 +0000

see: http://www.longecity.org/forum/topic/68167-guesteditors/

LongeCity Newsletter 1/2014

Sat, 18 Jan 2014 20:00:00 +0000

gathering ideas for 2014, leadership changes, guest editors sought

http://www.longecity.org/newsletter/LongeCityNewsletter_2014_01.htm

LongeCity Newsletter 12/2013

Fri, 20 Dec 2013 00:24:00 +0000

looking back- and looking forward
http://www.longecity.org/newsletter/LongeCityNewsletter_2013_12.htm

LongeCity 2013 science support fundraiser!

Fri, 04 Oct 2013 22:17:00 +0000

http://tinyurl.com/mitosens2013

Contribute today for the greatest 'bang for your buck' effect in supporting anti-aging research you can find this year!
All donations are trebled!

LongeCity Newsletter 9/13

Tue, 24 Sep 2013 00:29:00 +0000

SCIENCE FUNDRAISER LAUNCHED! Also: local meetings, columnist, consultations http://www.longecity.org/newsletter/LongeCityNewsletter_2013_09.htm

LongeCity News Aug.2013

Thu, 08 Aug 2013 22:08:00 +0000

New design, columnist F.Cortese, ads & promos, private groups feature, scientific references & filesharing
http://www.longecity.org/newsletter/LongeCityNewsletter_2013_08.htm