LONGECITY

Just read a bit about this. Supposedly it can help with depression and anxiety, among other things. Has anyone tried this and had any results good or bad with it?

Thx,

D

Aside from me, I've suggested it to a few people. The dropper bottle is a little difficult to get the right dose. You have to use tiny drops or your over dosing. It's a clotting factor, so you should probably keep a few aspirins in your pocket just in case it gives you problems. That's why I switched to using the the body spray (blood pressure was getting too high on the drops).

If you've been depressed for a long time or have deep problems, get ready for an adjustment if you use the drops regularly. It could be painful to see how far away you've been from where you should be.

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Thanks cryonicsculture. In my research, I'm seeing that it (evidently) does not cross the BBB when taken as a supplement and therefore (like taking GABA) should not be able to exert any type of neurologic benefit. There do seem to be some anecdotal reports here and there that it helps...but also a lot of naysayers...

My quest is for an anxiety treatment as I've tried most of the conventional ones.

It has to be able to cross the BBB... otherwise it wouldn't work as a human bonding hormone unless it causes some other catabolism that results in something crossing the BBB. It's recycled by citric acid IIRC.

OA is known to dilate things, perhaps it dilates it's way into the brain? Of course it's primary target is nerve cells, so it could work by activating something systemic. I've caught myself behaving under it's influence after wearing a shirt I had applied it to the day before. It does something and it does work with anxiety and depression. OA also plays a role in ejaculation and erectile function which have effects on the brain from a satellite location. It may not have to cross the BBB to be effective. I have a few bottles with a little bit left in them if you'd like to try it for yourself. I'm in Delaware, so you wouldn't have to wait long. PM me if you're interested I imagine I could mail it for under $5.

I have tried oxycalm nasal spray, it has an effect for 3 or 4 minutes but i couldn't judge it too well because i was withdrawaling from opiates at the time. Almost felt like there was a comedown effect after a few minutes.

i dont think oxytocin factor has enough oxytocin in it to do much from what i remember(why i chose the oxycalm) if i remember correctly it is sold by some guy who works with autistic kids and there was some controversy about him being a scam artist or something. it all seemed kind of sketchy.

Larger doses don't do better IMO, maybe initially, but the tiny amount is really all you need as it's a hormone with considerable potency. Considering the blood pressure spikes I had from it before I realized I was squeezing the dropper too much (I had initially assumed a drop was by one particular metric and found they were using another where there were more drops/ml) I was using aspirin to stem the BP somewhat regularly and my results were sustained. I even wore it and took the drops before visiting a friend of a friend who had aspergers (and while I'm not sure I agree with it as a disease not of social pathology...) and a fellow cryonicist hopeful, I was told by the individual that our conversation (about 10 hours) was the longest he'd ever had in a sitting (I let him know that I was on it by the end and explained it to him once before) We stopped talking however, I wonder if the loss of exposure had suddenly exhausted him in terms of social stamina...

All of my tests to see if I was experiencing placebo worked and I started to understand people much more clearly and developed a powerful insight I hadn't before. I imagine therapists don't want to lose the billable hours. Though I've never heard of ocycalm, and the stuff should last much longer in my experience, so it might well have been a scam. The body spray I have is more than a year old and it still worked last time I used it, so it it's not stable in the bottle as ABC Nutriceuticals says then they might not have as high quality starting materials. There are potentially other reasons why you might not want someone to use it. I'm a conscientious objector to the handling of people in those situations though. I'd rather have someone be emotionally functioning at 100% and my feelings on having any other standards for what is essentially a medical condition and is treated as one is that it's just inhumane plain and simple. You can't force/manipulate/suggest someone into ignorance with traumatic stress... that's just not medicine and it has a history of ending badly and is a very deathist approach.

i'm glad you had such success with it Cryonics, hopefully(for other people) I just either got scammed or something

Just FYI, the lethal dosage is pretty low IIRC, so I wouldn't go trying larger doses willy nilly.

Aside from me, I've suggested it to a few people. The dropper bottle is a little difficult to get the right dose. You have to use tiny drops or your over dosing. It's a clotting factor, so you should probably keep a few aspirins in your pocket just in case it gives you problems. That's why I switched to using the the body spray (blood pressure was getting too high on the drops).

If you've been depressed for a long time or have deep problems, get ready for an adjustment if you use the drops regularly. It could be painful to see how far away you've been from where you should be.

Hey cryonics do you still take it? From which website did you acquire this substance? It sounds very promising for those looking to become more social. This article seems to indicate that it might decrease avoidance behaviours. Do you still find it beneficial?

From another interesting article - 'Feldman’s work showed that how a 3-year-old child interacts with their best friend is determined in part by how their oxytocin system functions and in part by how their parents, particularly their mother, interacted with them. When playing with their best friend, children with higher levels of oxytocin and whose parents engaged in more parenting behaviors were more communicative and collaborative, two traits that help increase closeness and cement bonds.' and 'The child’s physiology also influenced how they behaved. Children with higher levels of oxytocin showed greater social reciprocity with their best friend.'

Aaaaand the last link, 10 pretty awesome effects of Oxytocin. Why in the world is this not more widely taken? Seems to me that it could be an excellent remedy for the widespread alienation of individuals from each other and the strengthening of social bonds.
Edited by OpaqueMind, 28 June 2013 - 02:15 PM.

After doing some research oxytocinfactor actually does provide about half what is being used in studies, the studies seem to indicate intranasal oxytocin has extremely specific effects on social cognition involving speech performance and stress response to certain facial expressions. I guess i should have given it a more thorough trial using it in social situations, i figured it would just relax me a bit even if i was just at home but maybe it only works for subtle social cues you might not even notice unless you really thoroughly exerimented with it. plus i think i was dosing far too high, possibly why i felt a sort of comedown effect. I think i will order some more oxycalm from IAS as the oxytocinfactor guys don't ship to canada.

 

Aside from me, I've suggested it to a few people. The dropper bottle is a little difficult to get the right dose. You have to use tiny drops or your over dosing. It's a clotting factor, so you should probably keep a few aspirins in your pocket just in case it gives you problems. That's why I switched to using the the body spray (blood pressure was getting too high on the drops).

If you've been depressed for a long time or have deep problems, get ready for an adjustment if you use the drops regularly. It could be painful to see how far away you've been from where you should be.

Hey cryonics do you still take it? From which website did you acquire this substance? It sounds very promising for those looking to become more social. This article seems to indicate that it might decrease avoidance behaviours. Do you still find it beneficial?

From another interesting article - 'Feldman’s work showed that how a 3-year-old child interacts with their best friend is determined in part by how their oxytocin system functions and in part by how their parents, particularly their mother, interacted with them. When playing with their best friend, children with higher levels of oxytocin and whose parents engaged in more parenting behaviors were more communicative and collaborative, two traits that help increase closeness and cement bonds.' and 'The child’s physiology also influenced how they behaved. Children with higher levels of oxytocin showed greater social reciprocity with their best friend.'

Aaaaand the last link, 10 pretty awesome effects of Oxytocin. Why in the world is this not more widely taken? Seems to me that it could be an excellent remedy for the widespread alienation of individuals from each other and the strengthening of social bonds.

 

I'd make sure to read this:
http://www.longecity...o-hard-to-beat/

I don't still use it, at least not often. I don't like the idea of long term use of things like this. You can take it, learn what you've been missing and see the world around you become more clear, but once you can grow without it, I wouldn't rely on it. Not enough is known currently.

I'd like to know how they measured the OF in children's brains though. That's kinda scary... The things I mention about assumptions in the topic I linked you to are very important when taking OF, I had assumptions I didn't even realize were assumptions and they sort of peeled off in layers and sometimes a thick layer would peel off and it would hurt alot. Eventually things normalize and your own levels should adjust as you learn to think beyond faulty assumptions. My advice would be to drop all assumptions, but this is hard if you don't know what your assumptions even are, so as a tool for learning, start by making a new assumption "You are stupid and everything you've ever done you did in ignorance," just start over, it will take less time than you think to make a considerable change to your life.

There are also foreign pharmacies that sell the stuff. 

The body spray is a very gentle experience and you have receptors in your nose for OF/OA, so keep it clean. The drops and nasal spray are a bit more dramatic at times and the drops are hard to get the dose right on sometimes as it comes down to pressure on the rubber cap by your fingers. The right dosage is the best, too much and you won't feel anything or will just get headaches. Keep some aspirin on hand as it can be a clotting factor.
 

After doing some research oxytocinfactor actually does provide about half what is being used in studies, the studies seem to indicate intranasal oxytocin has extremely specific effects on social cognition involving speech performance and stress response to certain facial expressions. I guess i should have given it a more thorough trial using it in social situations, i figured it would just relax me a bit even if i was just at home but maybe it only works for subtle social cues you might not even notice unless you really thoroughly exerimented with it. plus i think i was dosing far too high, possibly why i felt a sort of comedown effect. I think i will order some more oxycalm from IAS as the oxytocinfactor guys don't ship to canada.

How did they provide the dose? Was it a dropper or nasal spray? Did you swirl the bottle to mix it?

Edited by PerC, 24 September 2014 - 10:32 PM.

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Here's another source http://www.antiaging...tocin-love-drug
The clotting factor issue sounds pretty scarey though.