Emodin
edward
30 Apr 2007
Emodin, personally I'm one who doesn't tolerate it all that well. But it's nice to know that nasty bacteria, viruses and cancers tolerate it even less.
Just a sample of all the good things Emodin is doing in your body:
http://www.ncbi.nlm....1&dopt=Abstract
http://mct.aacrjourn...bstract/6/3/987
http://www.pubmedcen...gi?artid=176453
Med Sci Monit. 2006 Aug 25;12 (9):BR302-306 16940925
Inhibition of the replication of hepatitis B virus in vitro by emodin.
[My paper] Dang Shuangsuo , Zhang Zhengguo , Chen Yunru , Zhang Xin , Wang Baofeng , Yuan Lichao , Cheng Yan'an
Background: Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is derived from herbal medicines and proved to have a strong antimicrobial activity. However, its anti-virus effects are less known. The aim of the present study was to investigate the effects of emodin, interferon alpha (IFNalpha), and lamivudine (3TC) on hepatitis B virus (HBV) in vitro. Material/Methods: The human hepatoma G2.2.15 cell line stably expresses hepatitis B virus particles in culture. The cells were exposed to different concentrations of emodin, IFNalpha, and lamivudine triphosphate, respectively. MTT (methyl thiazolyl tetrazolium) assay was used to evaluate the cytotoxicity of the drugs and real-time PCR was applied to quantify extracellular HBV DNA. HBsAg and HBeAg were assessed by enzyme-linked immunosorbent assay (ELISA). Results: The results showed that exposure of HepG2.2.15 cells to emodin resulted in a time- and concentration-dependent inhibition of HBV DNA replication and HBsAg secretion. After exposed to three different concentrations of emodin for 3, 6, and 9 days, the inhibition rates of extracellular HBV DNA, HBsAg, and HBeAg of each concentration decreased significantly (P<0.05). After 9 days of treatment, the inhibition rates of extracellular HBV DNA of the different concentrations differed greatly (P<0.001). IFNalpha and 3TC had similar inhibition results to HBV DNA replication to those previously found. Conclusions: These findings suggest that emodin may prove to be a new modality to treat hepatitis B infection.
Just a sample of all the good things Emodin is doing in your body:
http://www.ncbi.nlm....1&dopt=Abstract
http://mct.aacrjourn...bstract/6/3/987
http://www.pubmedcen...gi?artid=176453
Med Sci Monit. 2006 Aug 25;12 (9):BR302-306 16940925
Inhibition of the replication of hepatitis B virus in vitro by emodin.
[My paper] Dang Shuangsuo , Zhang Zhengguo , Chen Yunru , Zhang Xin , Wang Baofeng , Yuan Lichao , Cheng Yan'an
Background: Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is derived from herbal medicines and proved to have a strong antimicrobial activity. However, its anti-virus effects are less known. The aim of the present study was to investigate the effects of emodin, interferon alpha (IFNalpha), and lamivudine (3TC) on hepatitis B virus (HBV) in vitro. Material/Methods: The human hepatoma G2.2.15 cell line stably expresses hepatitis B virus particles in culture. The cells were exposed to different concentrations of emodin, IFNalpha, and lamivudine triphosphate, respectively. MTT (methyl thiazolyl tetrazolium) assay was used to evaluate the cytotoxicity of the drugs and real-time PCR was applied to quantify extracellular HBV DNA. HBsAg and HBeAg were assessed by enzyme-linked immunosorbent assay (ELISA). Results: The results showed that exposure of HepG2.2.15 cells to emodin resulted in a time- and concentration-dependent inhibition of HBV DNA replication and HBsAg secretion. After exposed to three different concentrations of emodin for 3, 6, and 9 days, the inhibition rates of extracellular HBV DNA, HBsAg, and HBeAg of each concentration decreased significantly (P<0.05). After 9 days of treatment, the inhibition rates of extracellular HBV DNA of the different concentrations differed greatly (P<0.001). IFNalpha and 3TC had similar inhibition results to HBV DNA replication to those previously found. Conclusions: These findings suggest that emodin may prove to be a new modality to treat hepatitis B infection.
kurt
20 Aug 2008
Didn't mean to dig this old thread out, but I've been wondering if its safe to ingest emodin long-term?
