Small Cell Lung Cancer, Drugs and Supplements
tham 19 Feb 2009
Oldenlandia diffusa acts vide caspase 2 and 3.
Together with Scutellaria barbata, this is a common herb
in Chinese herbal formulas for detoxification which you
can find selling along road side stalls in Malaysia.
http://www.jcimjourn...x?articleID=585
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Lindera strychnifolia. Note that SBC-3 is a SCLC line.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.kalyx.com...1010.0/file.htm
Edited by tham, 19 February 2009 - 07:12 PM.
JLL 19 Feb 2009
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.
The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this 'miracle herb' in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (Velcade(®)) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the combination of these compounds would yield increased antitumor efficacy in multiple myeloma and glioblastoma cell lines in vitro and in vivo. Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by bortezomib in vitro and in vivo. This pronounced antagonistic function of EGCG was only evident with boronic acid-based proteasome inhibitors (bortezomib, MG-262, PS-IX), but not with several non-boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir). EGCG directly reacted with bortezomib and blocked its proteasome inhibitory function; as a consequence, bortezomib could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death. Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib and suggest that consumption of green tea products may be contraindicated during cancer therapy with bortezomib.
http://www.ncbi.nlm....pubmed/19190249
sponsored ad
tham 20 Feb 2009
if Kurt decides to give him bortezomib.
tham 23 Feb 2009
immediately the full study of his abstract on Oldenladia diffusa,
Glycyrrhiza glabra, PC-SPES and SPES, after I requested it from him.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.claremont...file.asp?Fac=80
http://www.jsd.clare...sp?FacultyID=29
Glycryrrhiza glabra is licorice.
Shortly after this study, PC-SPES and SPES were taken off
the market and the marketing company, Botanic Lab, closed
down after somewhat overblown fears of PC-SPES being
contaminated with warfarin and SPES with alprazolam (Xanax).
http://www.nature.co...l/1206242a.html
http://www.annieappl...alonpcspes.html
http://www.phoenix5....2602pcspes.html
http://www.lef.org/m..._profile_01.htm
Attached Files
Edited by tham, 23 February 2009 - 05:00 PM.
tham 24 Feb 2009
" The similarities in IC50 between drug-sensitive and multidrug
-resistant cells indicates that these extracts are not affected
by the drug resistance mechanisms displayed in H69VP (drug
resistant SCLC line), including overexpression of two drug
transporters, MDR1 and MRP (drug pumps). "
In Table 1, Oldenlandia diffusa is slightly more cytotoxic (IC50
of 0.99 mg/ml) than PC-SPES (1.23 mg/dl) and significantly more
than SPES (1.71 mg/dl) on the H69VP line.
Glycyrrhiza glabra (licorice) is ruled out due to its hypertension
side effect at the relatively high dosages required. Its cytotoxicity
on SCLC is due to necrosis rather than apoptosis, due to
overexpression of Bcl-2.
PC-SPES was originally developed for hormone refractory prostate
cancer, but also exhibits cytotoxic activity in other cancers, including
SCLC.
http://www.aacrmeeti...act/2004/1/691-
Its performance in prostate cancer appears impressive, so
the outcry by prostate cancer patients in the links above
when it was taken off markets was justified.
http://jn.nutrition....full/131/1/164S
tham 24 Feb 2009
It is now being remanufactured by a UK company, Active Botanicals Ltd, as PC-SPES 2, with improved qualitiy control.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.findowner...ls-ltd/2688038/
http://jn.nutrition....ll/132/11/3513S
http://meeting.ascop...ourcetype=HWCIT
http://www.ncbi.nlm....l=pubmed_docsum
http://cat.inist.fr/...&cpsidt=1269479
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Its upregulation/inhibition of the proapoptotic/antiapoptotic genes,
BAX, Bcl-2, Bcl-xL, caspase 3 and the tumor suppressor genes, p21
and p53, would explain its activity against SCLC as well.
tham 25 Feb 2009
http://www.aacrmeeti...ourcetype=HWCIT
Drug pumps in SCLC.
http://www.aacrmeeti...ourcetype=HWCIT
tham 27 Feb 2009
http://www.ncbi.nlm....st_uids=2544304
http://www.ncbi.nlm....st_uids=7867442
Alternating chemo protocols :
http://www.ncbi.nlm....st_uids=2994472
http://www.ncbi.nlm....st_uids=7786823
tham 16 Mar 2009
The Malaysian Prime Minister's first wife died of breast cancer
in 2005 shortly after returning from Abraxane therapy in LA.
Her twin sister died from the same disease in 2002.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://en.wikipedia....i/Endon_Mahmood
Docataxel (Taxotere), second generation taxane.
http://www.asco.org/...abstractID=2872
http://www.asco.org/...bstractID=33392
http://www.ncbi.nlm....l=pubmed_docsum
http://www.asco.org/...bstractID=13876
http://www.asco.org/...abstractID=2881
http://www.ncbi.nlm....l=pubmed_docsum
Marimastat.
http://www.asco.org/...p;abstractID=11
tunt01 30 Mar 2009
i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).
tham 31 Mar 2009
anyone know of any good protocols/suggestions for NSCLC? preferably for ex-smokers?
i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).
In Malaysia, you can commonly find vendors selling "cooling"
herbal drinks by the roadside.
These drinks are a concoction of herbs for general detoxification
and typically include two very common herbs used in tradional
Chinese Medicine :
Oldenlandia diffusa
Scutellaria barbata, or a related species, Scutellaria baicalensis
All three have anticancer activity against NSCLC, with Oldenlandia
also active against SCLC.
You could make a herbal drink of Oldenlandia and either of
the Scutellaria species, taking it say twice a week for prevention.
They can be found as whole herbs, powders, extracts or granules
in any Chinese herbal store. Extracts or granules are more
convenient. Extracts need only be steeped in hot water. Granules
are the most convenient - they dissolve instantly in hot or room
temperature water and drunk like a beverage. Whole herbs or
powders would need to be boiled for a few hours before their
essence is extracted.
http://www.kalyx.com...2855.0/file.htm
http://www.kalyx.com...6020.0/file.htm
http://www.kalyx.com...D/10.0/file.htm
http://www.kalyx.com...6020.0/file.htm
http://www.itmonline...oldenlandia.htm
http://www.cancerdec...81504_page.html
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
A549 is an NSCLC adenocarcinoma line.
http://www.ncbi.nlm....l=pubmed_docsum
Scutellaria baicalensis's anticancer actions are due largely
to its flavonoids, baicalen, baicalin, wogonin and chrysin.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Another herb which you could substitute in place of Scutellaria
is Lindera strychifolia, which has activity against both SCLC
and NSCLC.
SBC-3 is an SCLC line frequently used in testing drug resistance.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.kalyx.com...1010.0/file.htm
http://www.kalyx.com...6020.0/file.htm
A suggested dosage might be 1/3 to 1/2 teaspoon each of
the extracts or granules of the following in a glass of water
(extracts in hot water) taken twice a week. Otherwise, you
could ask the owner or counter staff of any Chinese herbal
store there for advice.
Oldenlandia
Scutellaria or Lindera
Frankly, Bill should be taking Oldenlandia and Lindera regularly,
but I wonder why he doesn't seem to have shown much interest.
http://www.ncbi.nlm....l=pubmed_docsum
tham 11 Apr 2009
The rationale for including imatinib is because it is also a
BCRP inhibitor.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://cancerres.aac.../full/64/7/2333
Expression of BCRP is linked to poor survival in SCLC.
http://www.ncbi.nlm....l=pubmed_docsum
tham 11 Apr 2009
http://www.ncbi.nlm....l=pubmed_docsum
Platinum-based chemo protocols have no advantage in survival
over non-platinum ones, and in fact worsens quality of life.
This is why I've never favoured Kurt giving Bill cisplatin and
then carboplatin.
http://www.ncbi.nlm....l=pubmed_docsum
Scottish SCLC patients fare worse than their counterparts in
British Columbia.
http://www.ncbi.nlm....l=pubmed_docsum
Raised serum urea before chemo worsens survival.
http://www.ncbi.nlm....l=pubmed_docsum
tham 11 Apr 2009
Many of the latest drug regimens have good responses,
but so far none of them have made any difference to
survival times over the past 20 or 30 years.
Resistance rapidly sets in after the initial response.
http://www.ncbi.nlm....l=pubmed_docsum
This is why I had suggested to Bill that he try alternative
medicine like homeopathy or perhaps traditional Chinese
medicine, along with methyl jasmonate and the other
adjuvant drugs, herbs and supplements, excluding resveratrol
and quercetin.
bixbyte 06 Nov 2009
anyone know of any good protocols/suggestions for NSCLC? preferably for ex-smokers?
i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).
Here is a Cancer "Cure" medication approved only for use in Russia called NOV-002
Currently being tested under FDA Phase III trials under Special Protocol Assessment and Fast Track in the USA.
The test patients appear to be failing to die from their cancer and the tests has been continued for an extra 6 months and might be continued for even another 3 or 6 more months!
Standard Chemo 17%
NOV-002 adjunctive with Chemo Increased Cancer survival to 63%
http://www.novelos.com/
http://www.novelos.c...ls_frameset.htm
http://en.wikipedia.org/wiki/NOV-002
http://www.cancer.go...earchid=2669713
http://clinicaltrial...how/NCT00347412
If you need this medicine right away and have a lot of money you can make an appointment, the only Doctor, for the "Cure"
http://www.tiopoietine.info/index.htm
Good Luck!
Bix