LONGECITY

https://link.springe...2640-018-9925-z


Methamphetamine (METH), an amphetamine derivate, may increase the risk of developing Parkinson’s disease (PD). Human and animal studies have shown that METH produces persistent dopaminergic neurotoxicity in the nigrostriatal pathway, despite initial partial recovery. To determine the processes leading to early compensation, we studied the detailed morphology and distribution of tyrosine hydroxylase immunoreactive fibers (TH-ir) classified by their thickness (types I–IV) before and after METH. Applying three established neurotoxic regimens of METH: single high dose (1 × 30 mg/kg), multiple lower doses (3 × 5 mg/kg) or (3 × 10 mg/kg), we show that METH primarily damages type I fibers (the thinner ones), and to a much lesser extend types II–IV fibers including sterile axons. The striatal TH terminal partial recovery process, consisting of a progressive regrowth increases in types II, III, and IV fibers, demonstrated by co-localization of GAP-43, a sprouting marker, was observed 3 days post-METH treatment. In addition, we demonstrate the presence of growth-cone-like TH-ir structures, indicative of new terminal generation as well as improvement in motor functions after 3 days. A temporal relationship was observed between decreases in TH-expression and increases in silver staining, a marker of degeneration. Striatal regeneration was associated with an increase in astroglia and decrease in microglia expression, suggesting a possible role for the neuroimmune system in regenerative processes. Identification of regenerative compensatory mechanisms in response to neurotoxic agents could point to novel mechanisms in countering the neurotoxicity and/or enhancing the regenerative processes.

List of neuroregenerators:
EGCG(of animals treated with EGCG showed a remarkable axonal and myelin regeneration
and contained a greater number of large newly regenerated nerve fibers ) https://www.scienced...197018613000028
Curucmin (Curcumin is capable of promoting peripheral nerve regeneration in normal condition.
However, it is unclear whether its beneficial effect on nerve regeneration still exists under
diabetic mellitus.) https://www.scienced...304394015302421
Black pepper extract (Exposure of P388D1 cells to high concentrations of black pepper extract led to enhanced
proliferation of these cells) "An in vitro study of the immunomodulatory effects of Piper nigrum (black pepper) and Elettaria cardamomum (cardamom) extracts using a murine macrophage cell line"
NAC ( . Several lines of evidence suggest that oxidative stress may play a role in the behavioral
changes and neurotoxicity in rats after administration of methamphetamine (MAP).
N-acetyl-l-cysteine (NAC) is a precursor of glutathione) https://www.nature.c...rticles/1300512
Vitamins ABCDE ( as BDNF and Sir2. Keywords traumatic brain injury, hippocampus, learning, BDNF,
vitamin E Introduction … hippocampus of FPI rats. (A) FPI resulted in reduction of BDNF,
whereas vitamin E supplementation reversed these effects) http://journals.sage...545968309348318
Alpha-GPC (Lower in meth neurotoxicity) https://www.nature.c...cles/npp2009221
Cholinergics of all kinds https://www.nature.c...cles/npp2009221
Endocannabinoids https://www.scienced...028390814001099 (Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors)
Cannabinoids https://www.scienced...376871604001267 http://journals.plos...al.pone.0098079
Exercise https://estudogeral....dle/10316/28071 http://www.jneurosci.../42/11442.short
Nicotine http://jpet.aspetjou...jpet.114.221945
Niacinamide https://www.scienced...304394000008545 https://onlinelibrar...1998.71020613.x
Anti-oxidant blend(ALA melatonin etc) https://journals.lww...revents.39.aspx
seems like a valid neural regeneration kit?
Edited by Ruth, 27 July 2018 - 10:28 PM.

List of neuroregenerators:
EGCG(of animals treated with EGCG showed a remarkable axonal and myelin regeneration
and contained a greater number of large newly regenerated nerve fibers ) https://www.scienced...197018613000028
Curucmin (Curcumin is capable of promoting peripheral nerve regeneration in normal condition.
However, it is unclear whether its beneficial effect on nerve regeneration still exists under
diabetic mellitus.) https://www.scienced...304394015302421
Black pepper extract (Exposure of P388D1 cells to high concentrations of black pepper extract led to enhanced
proliferation of these cells) "An in vitro study of the immunomodulatory effects of Piper nigrum (black pepper) and Elettaria cardamomum (cardamom) extracts using a murine macrophage cell line"
NAC ( . Several lines of evidence suggest that oxidative stress may play a role in the behavioral
changes and neurotoxicity in rats after administration of methamphetamine (MAP).
N-acetyl-l-cysteine (NAC) is a precursor of glutathione) https://www.nature.c...rticles/1300512
Vitamins ABCDE ( as BDNF and Sir2. Keywords traumatic brain injury, hippocampus, learning, BDNF,
vitamin E Introduction … hippocampus of FPI rats. (A) FPI resulted in reduction of BDNF,
whereas vitamin E supplementation reversed these effects) http://journals.sage...545968309348318
Alpha-GPC (Lower in meth neurotoxicity) https://www.nature.c...cles/npp2009221
Cholinergics of all kinds https://www.nature.c...cles/npp2009221
Endocannabinoids https://www.scienced...028390814001099 (Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors)
Cannabinoids https://www.scienced...376871604001267 http://journals.plos...al.pone.0098079
Exercise https://estudogeral....dle/10316/28071 http://www.jneurosci.../42/11442.short
Nicotine http://jpet.aspetjou...jpet.114.221945
Niacinamide https://www.scienced...304394000008545 https://onlinelibrar...1998.71020613.x
Anti-oxidant blend(ALA melatonin etc) https://journals.lww...revents.39.aspx
seems like a valid neural regeneration kit?

I take all of these except black pepper extract. I have to order that now LOL

I wonder what the dosage is for the high concentrations they recommend
Edited by John250, 27 July 2018 - 10:49 PM.

I take all of these except black pepper extract. I have to order that now LOL

I wonder what the dosage is for the high concentrations they recommend

Hmmm I looked at this supplement for curcumin which contains 3mg of black pepper extract which is standardized to contain 95% piperine.

Hmmm I looked at this supplement for curcumin which contains 3mg of black pepper extract which is standardized to contain 95% piperine.

Thanks. I just ordered the 10 mg Bioperine as well as this cardamom

https://www.amazon.c...e/dp/B000JMBEEK

I have some of them (e.g. Green Tea Extract, Curcumin, N-Acetyl-Cystein, Vitamins anyway), however I'm still waiting for even small improvements to my Akathisia or sexual anhedonia from SSRI.
Edited by MattH, 28 July 2018 - 05:35 AM.