LONGECITY

At least this report says it is in higher dosages: 

https://www.ncbi.nlm...les/PMC2990065/

Reading this got me worried about my intake. I used to take 1000 mg sublingual, but after reading it I dropped to 500 mg and also started taking it orally instead (which might be useless?).

Anyway, what I'm wondering is if it's actually known at what dose Resveratrol starts becoming a pro oxidant? 

Also while I'm at it, what do you think about taking Resveratrol sublingual? 

No one has an opinion on this? I've stopped taking it as it seems risky if we don't know the dosages that actually do more harm than good. 

No one has an opinion on this? I've stopped taking it as it seems risky if we don't know the dosages that actually do more harm than good. 

Here's one thread, I've seen several recently about this. My opinion, if it were a huge issue, more people would be concerned than apparently are. But it is interesting, nonetheless.

https://www.longecit...atrol-a-review/

Here's one thread, I've seen several recently about this. My opinion, if it were a huge issue, more people would be concerned than apparently are. But it is interesting, nonetheless.

 

https://www.longecit...atrol-a-review/

Thanks for the link!

Yeah, well, either that or there hasn't been enough conclusive research on the matter. 

I have very limited knowledge about resveratrol and longevity overall, but if we don't know for sure what doses are harmful and at the same time don't know how helpful it can actually be (due to bad bioavailability, correct me if I'm wrong), it makes me wonder if it's worth taking at all. 

Thanks for the link!

Yeah, well, either that or there hasn't been enough conclusive research on the matter. 

 

I have very limited knowledge about resveratrol and longevity overall, but if we don't know for sure what doses are harmful and at the same time don't know how helpful it can actually be (due to bad bioavailability, correct me if I'm wrong), it makes me wonder if it's worth taking at all. 

Good point. I think it may be some good for some, not for others, dosage is unclear, and it's not cheap. But truefully, that the same for many supplements. It ends up being a personal decision.

Resveratrol's mechanism of action (as I understand it), is sirtuin activation. In some circumstances it can lead to mitochondrial fission via SIRT1 and this would lead to a short term rise in ROS, but long term would likely lead to healthier mitochondria and lower ROS. But it's not so simple as this, as in some conditions (i.e. after a large meal) SIRT4 reduces cellular proliferation and increases mitochondrial fusion and fat storage.  So it seems it can have different effects depending on the state of feeding.

I think on balance resveratrol is a healthy supplement that isn't very bioavailable. When I've taken it before it generally makes me leaner (but I took it on an empty stomach), and it aids my cognition and exercise performance. But it reduces my sex drive, so I never stay on it for long. I have more recently experimented with resveratrol (and pterostilbene, which has a longer half life) in a well fed state (see https://www.longecit...s/#entry857309)and haven't suffered from the reduced sex drive. I have a working theory (sorry, no reference) that resveratrol is great for overweight people, but if you're already lean, it may well (as an aromatase inhibitor) reduce your estrogen to such an extent it reduces your sex drive (men need a certain level of estrogen).