Low dose NMN increases fertility in old mi...
MikeDC 15 Feb 2020
2.0g/L has slight negative effect
0.5g/L corresponds to 340mg NR for a 50kg person
0.5g/L corresponds to 500mg NMN for a 50kg person
https://www.ncbi.nlm...ubmed/32049001/
FancyNancy 17 Feb 2020
Thanks for this information! Just curious, did you calculate the human dosage yourself or find it somewhere? I'm trying to figure out the best dosage to take, i've been taking NMN for awhile now but it seems I've been taking too much
able 17 Feb 2020
Alivebynature says the low dose equals 350 mg NMN and high dose is 1400 mg.
https://alivebynatur...ge-suggestions/
I guess that may explain why studies or self-experiments with 2 or 3 grams of NMN or NR don't find great results - may actually be worse.
I've been thinking that a large dose just increases need for methyl donors.
But if too much NMN/NR -> excess NAM -> inhibits sirtuins, would methyl donors even fix the issue?
MikeDC 18 Feb 2020
Thanks for this information! Just curious, did you calculate the human dosage yourself or find it somewhere? I'm trying to figure out the best dosage to take, i've been taking NMN for awhile now but it seems I've been taking too much
I did it myself. The number depends on assumptions. So everyone will come up with a different number.