LONGECITY

What's would you include as the top cancer prevention biohacks? Based upon a couple of books I've read I would include...

• Vitamin D
• Magnesium
• C60
• Infrared light therapy
• Fasting
• Mitigate lectins (reading the Plant Paradox now)
• MItigate EMFs

What else would you include? If you had a limited budget what would you select?

Quercetin and Curcumin

Princeton suggest, curcumin 95(Jarrow) , I like the new LEF formulation, curcumin elite.

Natural factors has few formulations of quercetin.

Get thee to a blood bank! 

https://www.longecit...otoxic-disease/

It's human nature to believe cancer prevention must involve elaborate combinations of a Spartan diet, daily strenuous exercise, and magical supplements, but cancer free longevity may be easier than we think.  

Dorian might be on spot according to recent research on diluting or replacing blood (e.g. see the body of work at Wyss-Coray and Conboy labs):

https://www.longevit...asma-therapies/

https://www.pharmace...-buys-alkahest/

https://www.longecit...ndpost&p=893076

I also stand with Dorian since long on his iron considerations triggering my little but but so far good experimentation with IP6 (dietary phytate) as iron chelator. Not a coincidence LEF lists it as anti-cancer in its Disease Prevention & Treatment book (p. 304 of the 5th edition). Also there is recent and tantalizing research on haem metabolism and aging:

https://www.nature.c...467-020-17312-3

Something which maybe can be added here, not really discussed much in the LC forum (or am I overlooking?) …

When on nutrition, I think it is important to monitor the free fatty acid (FFA) profile which gives a pretty good picture of your dietary trends and is not really expensive to do.

You get a breakdown of all FFA. You can look a pro-inflammatory (often, but not always-see GLA, omega-6) and anti-inflammatory FFA (e.g. omega-3) with ratios which have clinical relevance. And we know how cancer is linked to inflammation! Something I am looking recently is omega-6 linoleic acid (do not confuse with linolenic) which is not carcinogen but is linked to tumor growth promotion: “…There is no direct evidence that linoleic acid is a carcinogen. There is, however, compelling evidence that in some species and under some conditions linoleic acid can act as a promoter of tumor growth…” (https://pubmed.ncbi....h.gov/28531128/).

Thomas Levy believes excess calcium in cells is a big cause of cancer

"It became apparent to me and I’ve not found an exception to this yet, which is every cell that is “diseased” has increased calcium levels inside the cell… It’s the highest levels of calcium that also result in cancer."

"I consider Vitamin C, magnesium, Vitamin D, and Vitamin K2 to be the premier, top four supplements for promoting and maintaining good health. Mainly because they’re the primary antagonists to calcium accumulation and excess calcium inside the cell"

As far as lectins go, I think that would depend on age. Lectins and one's sensitivity to them can, from what I've read, be used in a senolytic or anticancer manner and may themselves play a role in preventing cancer from taking hold. So a little bit of gut hurt and headaches from infrequent, though not chronic or low grade, exposure can kill cancer. I've been thinking that swapping out my lectin sensitivity gene for the more convenient variant might be desirable at some point, but given how it works in the landscape of my genetics, I would have to make other anticancer improvements in order to achieve a net zero or better cancer risk.

Two potentially powerful instruments:

Optimum health and inhibition of cancer progression by microbiome and resveratrol

"Resveratrol (RES) is a naturally occurring polyphenol found in fruits, green leafy vegetables, and peanuts. This versatile compound, which has potent regenerative, anti-oxidative, and cancer-fighting properties, is produced in plants, particularly in response to stress stimuli. By various mechanisms, including regulation of genes and proteins, RES inhibits the growth of pathogenic bacteria and the development of cancers. The gut has a prominent role in nutrient assimilation, metabolism, immunity, and cancer regression, and the endogenous microbiome protects the host from invasive bacteria that facilitate the progression of various diseases. Short-chain fatty acids (SFCAs) are the byproducts of microbial fermentation in the gastrointestinal tract. Native microflora regulates internal homeostasis, influence the activity of host immune cells, and regress some cancers via the action of SCFAs produced from a plant-based diet. This review shows the relevance of dietary constituents and gut microbial activity in ensuring optimal health of the host."

https://pubmed.ncbi....h.gov/33049680/

Please don´t forget this thread for cancer prevention :

https://www.longecit...vention-thread/

With the insights of this community and some books I've read, I've created a prevention protocol, involving...

• Superantioxidants - C60
• The Plant Paradox diet
• EMF mitigation
• Red light therapy 
• Negative ion exchange with the planet
• Fasting

Some extra Links

Vitamin D - https://www.grassroo...-chart-in-ngml/

Quercetin(sold with bromelain for absorbtion)  + curcumin(brand really matters, I like Life extension)  - https://pubmed.ncbi....h.gov/30599890/

Mushroom extracts(increase natural killer cell activity 3x) + vitamin C(look for time release or take through out the day) - https://www.jeffbake...r-killer-cells/

Keto diet, many cancers love sugar(fruits, bread, pasta, sweets).  I dont recommend keto long term, but good short term for cancer.  Keto switches your body to burning fats for sugar. - https://www.carbmana...keto-and-avoid/

This was new to me. In vitro research showed that some tumor cells are vulnerable to large doses of DHA.

https://www.eurekale...l-aot061021.php

I'm not a huge fan of Dr. Gregger but this sounds interesting.

Metastatic effect of saturated fats, especially palmitic acid:

What Causes Cancer to Metastasize? - YouTube

I'm not a huge fan of Dr. Gregger but this sounds interesting.

 

Metastatic effect of saturated fats, especially palmitic acid:

 

What Causes Cancer to Metastasize? - YouTube

Good finding. It is why after several free fatty acid (FFA) panel results I try to keep in check palmitic acid in particular limiting dairy (already low in red meat) and cacao, both rich in this FFA. I find it hard though... Very interesting the point on the CD36 inhibition.
 

Interesting clinical trial on subject matter:

Bischoff-Ferrari HA, Willett WC, Manson JE, et al. Combined vitamin d, omega-3 fatty acids, and a simple home exercise program may reduce cancer risk among active adults aged 70 and older: a randomized clinical trial. Front Aging. 2022;3:852643.

https://www.frontier...022.852643/full

"...Supplementation with daily high-dose vitamin D₃ plus omega-3s, combined with SHEP, showed cumulative reduction in the cancer risk in generally healthy and active and largely vitamin D–replete adults ≥70 years..."

"...Supplemental 2000 IU/day of vitamin D₃, and/or 1 g/day of marine omega-3s, and/or a simple home strength exercise (SHEP) programme compared to placebo and control exercise...."