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Fisetin and Bleeding

JimWoodall's Photo JimWoodall 10 Mar 2021

My first fisetin cycle, I stopped working out with weights for a week after doing the cycle, I didnt shave or do anything in the yard.   I did this because I have read the story of the man who cut himself shaving and also read it repeated many times that bleeding could be a problem, and workouts should be minimal.

 

Slowly after several cycles I have gotten less and less strict. 

 

Now this last cycle, I did not change anything with my weight training and lifted hard as normal.  Continued normal functions.    About 7 hours ago, I went accidentally kicked my foot into a steal bar.   It was terribly painful.  Certainly some blood vessels must have broken.  I'm fine, no big bruise, my foot was sore for a few hours but it's fine now.

 

I think if there was a bleeding or body repair type problem with fisetin, I word have experienced that this last cycle.   

 

1600mg X 2 days every 3-6 months..

 

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JimWoodall's Photo JimWoodall 10 Mar 2021

I am about 24 hours since my last fisetin dose.  Maybe 1 hour ago I bit my lip and it bled.  There was no bleeding issue.  Either the fisetin I am using from donotage  is not real or there is no bleeding problem with fisetin (for me anyways).

 

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Karazantor's Photo Karazantor 13 Mar 2021

I've completed 2 cycles of 3g Fisetin plus a few other components (Quercetin, Longvida Circumin) following Piperine and Pink Grapefruit, 3 consecutive days and then repeated the next month. First end of 2019 and then Jan/Feb 2021.

 

I can confirm despite a few nicks shaving and minor scrapes over the time, absolutely no observed bleeding or healing issues outside of normal.

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kurdishfella's Photo kurdishfella 27 Jun 2022

Does your fisetin supplement contain any high vitamin K or calcium or anything with clotting agents effects? could be counteracting it.


Edited by kurdishfella, 27 June 2022 - 11:50 AM.
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ambivalent's Photo ambivalent 25 Aug 2022

Well, I was that guy. As I mentioed before, there was likely only a narrow window of vulnerability and I took quite high doses, with I hoped, improved bioavailability. A week after the wart nick while shaving, I expereinced quite a significant dental bleed and waited nervously but it was fine. The other instance was probably a couple of years later with a small cut on the hand. And I would have forgotten about if I had thought at the time it was odd it was taking so long maybe half an hour, and then realised I had taken fisetin a day or two earlier. That instance wouldn't have been noteworthy without the prior one which took 3 hours but was extremely low in volume. 

 

Now, these two events were quite unlikely and they could have easily not occurred and I would be in the "nothing to see hear" camp. And it hasn't been a regular problem with me, that aside I too have had many nicks and scratches with nothing ado. It would seem likely that if there is a problem then there is some homestatic responce, as is biology's way.

 

The other person to note a problem is lost69 who took sustained high doses over lengthy periods. A regular swimmer he picked up a skin infection and struggled to remove it with two course of anti-biotics, as I recall. That spooked him enough for him to quit the protocol. 

 

It is quite clear that it isn't a huge problem given the failure to report many instances and fisetin's widespread use. But the two reporting it were dosing outliers and as I said they were events only few in number - it remains possible at least that a high doser might marry to the wrong circumstance. And if some delayed healing does occur amongst the masses taking fisetin then many might not attirbute it to fisetin - if I hadn't known  the role of senescent cells can play in wound healing and past problems with senolytics, I may well not have paid enough attention, nor I doubt would have lost69.

 

 

 

 

 

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