LONGECITY

Hi, I've been poking around to try to find any studies that give an indication of how much GHK-Cu administration alters epigenetic age, according to epigenetic clocks such as GrimAge or DunedinPACE.

There are tons of papers on the benefits of GHK-Cu, including

https://www.ncbi.nlm...les/PMC6073405/

https://www.hindawi....ri/2015/648108/

https://pubmed.ncbi....h.gov/25745767/

https://pubmed.ncbi....h.gov/29986520/

Does anyone know if any studies have been done showing an impact on epigenetic age?

GHK-Cu oral use vs topical use?  Something good for local tissue may be bad in systemic circulation (where many interactions are happening). I can vouch for GHK-Cu topical use (I checked your first link it appears topical use).  Also too high GHK-Cu topically will start circulating in your body, which may be ok, though if there is Resveratrol in circulation at that time, the effect may turn as increased DNA damage. 

It seems you use Resveratrol.  A great choice, I love taking it for oral / systemic use.  Use it topically on your skin, over time you will start appreciating my pictures (pun intended). 

What is good to flow through blood may not be good for what sits on your skin.  You want higher skin turnover for preventing wrinkles, but you want the opposite to happen within your body. 

// Few people ever explain these simple concepts, even researchers conduct incorrect research studies ignoring context sometimes (or often depending on your perspective).  Also do not assume if result will be positive or negative for systemic epigenetic age with respect to GHK-Cu in particular.  Topical (i.e. skin) age testing should certainly show reduced age

GHK-Cu oral use vs topical use?  Something good for local tissue may be bad in systemic circulation (where many interactions are happening). I can vouch for GHK-Cu topical use (I checked your first link it appears topical use).  Also too high GHK-Cu topically will start circulating in your body, which may be ok, though if there is Resveratrol in circulation at that time, the effect may turn as 

What can you say about GHK-cu topical use? 

Basically, I already stated, my overall experiences are limited despite my dawning age.  What I can say is I did find Cu intriguing, it bonds with Amino acids in a solution without even adding a catalyst, and with some HCL you can experiment making your own designer peptides with it.  As for GHK-Cu, I found it too-encouraging that I have left it alone for now, for later times when I am thinking more properly.  Few experiences/observations I can say:

a) (my bones are weirdly flexible), I applied it on a ancient bad big toe injury, a bone spur formed rapidly (on surface this was not good), however that has stopped pain since.  This to me is indicative of bone growth i.e. stabilizing an injured toe.  // my one fear is, if it hardens cartilage. 

b) Applied it on face, felt it circulating in body, with encouraging effect on face.  

c) applied it on tummy, it literally started making noises indicating that it penetrated and was doing something.  On that day when I used, I judged the effect as not positive. 

Overall, I think its a potent growth factor, that you have to be cautious, with what may/may not be circulating in your body at the time.  I think anti-oxidants floating in your circulation do not play well with GHK-Cu so timing is very important.  But thats just my one person observation.  Others have posted about GHK-Cu (as if some secretive underground drug), as people stay mum on their experience when asked any further on it.   

What can you say about GHK-cu topical use? 

I'm really looking for any sort of objective data on how it impacts epigenetic age.

I do topical and injected GHK-Cu, though I've also tried sublingual (SuperSmart brand) in the past.

Zero. Based on my experiences.

 

Looking for objective data here, and more than an N of 1.

C60 is something you should consider

 

That would be very helpful, good or bad (I cannot pass verdict), GHK-Cu is potent, it does and drives changes. I think the issue is, who would want to (except some dedicated individual wanting to finding things out), as there is little financial incentive here. 

 

I'm really looking for any sort of objective data on how it impacts epigenetic age.

Dr Brad Stanfield on C60: 

It's flat-out irresponsible to take something like that.