Centrophenoxine Risk-Benefit Analysis
Fafner55
06 Oct 2022
Be aware that the DMAE moiety of centrophenoxine can enter the choline synthesis cycle and consequently increase the brain’s acetylcholine supply. In my case, 300 mg/day centrophenoxine led to feelings of depression within a week, probably through an increase in choline levels. I discontinued taking it after 10 days.
Acetyl-L-Carnitine might work by the same mechanism. ALCAR has a chemical structure that is similar to choline, but unlike choline, carnitine is not a neurotransmitter and has fewer reported side effects. It has been shown to reduce lipofuscin levels in aged rats.
- "Effects of Acetyl-L-Carnitine on the Brain Lipofuscin Content and Emotional Behavior in Aged Rats" (1988) https://doi.org/10.1254/jjp.48.365
- "Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment" (1989) https://doi.org/10.1...4943(89)90035-6
- “Anti-aging Effects Of Acetyl-L-Carnitine” (2000) https://www.lifeexte...e/2000/5/cover2
