Can anyone help me synthesize or purchase...
User4656
19 Mar 2023
Is there anyone who synthesizes chemical compounds or has a license to purchase them from vendors?
I would pay you to synthesize or purchase the phosphodiesterase 7 inhibitor S14 from a vendor - sigmaaldrich.com, medkoo.com, ...
Or the compounds BRL50481, 3-phenyl-2,4-dithioxo-1,2,3,4-tetrahydroquinazoline, Kenpaullone, Smilagenin, or 6-fluoro-9-methyl-β-carboline.
S14 inhibits the PDE-7 enzyme, which in turn promotes the differentiation of neural stem cells towards a dopaminergic phenotype and induces the proliferation and differentiation of dopamine precursor cells. It should increase in the number of dopaminergic cells in the substantia nigra pars compacta, an increase in the density of dopaminergic fibers in the striatum.
I suffer from haloperidol-induced loss of neurons for 7 years. Haloperidol's metabolites HPP+ and RHPP+ are neurotoxic to dopaminergic and serotonergic neurons:
https://phmd.pl/resources/html/article/details?id=141897&language=en
