LONGECITY

Zoom Link: April 5, 2023, @ 7pm Pacific Time

https://us02web.zoom.us/j/81643696466?pwd=bk1ZVll6SEw5dUkzZzdmcDZPSUpydz09

Evidence and insight from several recent longevity science studies constitute a turning point for Longevity Science Enthusiasts.

We now know that Aging Factors Exist in our Blood Plasma. And we know there are ways to

• reduce/dilute these factors, and by doing so
• increase health and survival probability

There are several Interventions we can do now to reduce/dilute these factors. Some of these interventions are new, others are ancient.

If done optimally in an informed way, these interventions can have a significant positive impact for 1 to 3 days; it not done optimally or done haphazardly, the Interventions make for only a marginal positive difference.

These approaches include

• ingesting anti-inflammatory foods and/or supplements
• engaging in behaviors that result in anti-inflammatory processes
• triggering the Cholinergic Anti-Inflammatory Pathway

Recently, a technology-based approach has also appeared on the scene. It’s FDA-approved to treat a large number of health disorders. It dilutes these (Inflammatory) Aging Factors more completely in a few months. Experiments demonstrate that it results in a younger gene expression profile. This Intervention is a kind of Biological Gene Expression reset and it’s called

• Therapeutic Plasma Exchange, or
• Plasmapheresis

In this talk, we will

• summarize the methods we can do now and the benefits we can derive from them
• outline the approach and usefulness of the technology approach: Therapeutic Plasma Exchange
• explain how we KNOW these two kinds of interventions are addressing the exact same profound cause of aging
• summarize a first draft Longevity-Promoting Regimen Sequence using both these intervention approaches
• explain all the graphical elements in the meetup header
• make time for Comments and Q&A

Resources for the Discussion

About the Aging Factors in the Blood Plasma

— 15 minute overview of plasma dilution by Sheekey Science

— 42 minute interview of the Conboys about plasma dilution

— 26 minute talk by Dobri Kiprov about TPE for Rejuvenation

— Dobri Kiprovs key 2013 “Hypothesis Paper”

— Conboys/Kiprov key Aug-2022 paper about Rejuvenation via Dilution

About the Cholinergic Anti-Inflammatory Pathway

— 20 minute talk by Kevin Tracey about the CAP

— 58 minute talk by Kevin Tracey about the CAP

— Kevin Tracey’s 2002 CAP ‘Hypothesis Paper”

— Kevin Tracey’s key 2009 CAP Review about intra-cellular objects

…… I’ll be referencing Figure 2 prominently in the talk

…… Figure 2 –> Most Predictively Significant Scientific Diagram Ever?

— Kevin Tracey’s key 2012 CAP description with key diagrams

My name is Steve Buss and I'm the person doing the talk next Tuesday, April 5,2023, at the Zoom link above.
 
The full talk title has been cut short in the Longecity post above. The full title appears in the image below.
 
In the talk content bullet points listed above, I mention...

• summarize a first draft Longevity-Promoting Regimen Sequence using both these intervention approaches

That summary will include

• a graphical depiction of what I now believe is the optimal sequencing of Plasmapheresis and Cholinergic Anti-Inflammatory Pathway Interventions
• the reasoning/explanation of that sequencing

I plan on attending the presentation. Thanks for alerting the community Steve!