LONGECITY

According to ChatGPT, Thiazole-based derivatives activate SIRT1 more than resveratrol:

 

 

"Resveratrol is not the only supplement that activates SIRT1. While resveratrol has been widely studied for its potential to activate SIRT1, there are other compounds that have shown to be more potent in activating this enzyme.

 

A study published in the journal Molecules tested multiple thiazole-based derivatives and found that some of these compounds activate SIRT1 more than resveratrol. These derivatives were shown to have a greater potential for activating SIRT1, indicating that resveratrol is not the only supplement capable of activating this enzyme.

 

Furthermore, the study mentioned earlier also highlights that there are seven human homologs of the yeast Sir2 protein, known as sirtuins, including SIRT1-7, which are NAD-dependent enzymes. These sirtuins play significant roles in various cellular processes and are potential targets for activation.

 

It's important to note that while resveratrol has been extensively studied and has shown promising effects on SIRT1 activation, there is ongoing research exploring other compounds and their potential to activate sirtuins. Future studies may identify additional supplements or compounds that can effectively activate SIRT1 or other sirtuins.

 

Thiazole-based derivatives are chemical compounds that contain the thiazole moiety as a structural component. Thiazoles are five-membered heterocyclic rings composed of three carbon atoms, one nitrogen atom, and one sulfur atom. Thiazole derivatives have gained significant attention in medicinal chemistry due to their diverse biological activities and potential applications in drug development.

 

Thiazole-based derivatives have been extensively studied for their pharmaceutical properties, including antifungal, antimicrobial, anti-inflammatory, analgesic, anticancer, anticonvulsant, and antiviral activities. They have been used in the development of drugs for the treatment of allergies, inflammation, HIV infections, hypertension, bacterial infections, schizophrenia, pain, and as antithrombotic agents.

 

Thiazole derivatives have been considered as a promising scaffold for generating new molecules with improved potency, lower toxicity, and desired pharmacokinetic profiles. Researchers have focused on synthesizing and characterizing novel thiazole-based derivatives to explore their potential as antitumor agents, antifungal agents, antimicrobial agents, acetylcholinesterase inhibitors, and as inhibitors of enzymes such as EGFR/HER2 kinase and DHFR.

 

Thiazole-based derivatives exist in supplement form. Thiazole is a five-membered aromatic heterocycle containing three carbon atoms, one nitrogen atom, and one sulfur atom. It is commonly found in various pharmacologically active compounds. Thiazole-based derivatives have been studied for their pharmacological potential and exhibited antibacterial, antifungal, anti-inflammatory, antioxidant, antiproliferative, and acetylcholinesterase inhibitory activities. Thiazole derivatives have also been recognized for their wide spectrum of biological activities and have been considered as a scaffold to generate new molecules with improved potency and lower toxicity. However, it is important to note that specific thiazole-based derivatives in supplement form would require more specific information or a targeted search to provide a comprehensive answer.

 

 

 

 

 

 

 

 

 

Generally you have to be very careful with ChatGPT and other language models because they make stuff up, including fake references. You have to double check everything manually.

 

In this case, there does seem to be some truth in it:

 

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives
https://www.ncbi.nlm...les/PMC9570679/

 

Only one tested compound activated SIRT1 more than reseveratrol, and it was 16% more. And that one was synthetic and not available anywhere.