Why does David Sinclair take 1 gram of resveratrol? - Resveratrol

Why does David Sinclair take 1 gram of res...

osris 17 Mar 2024

David Sinclair says he takes 1 gram of resveratrol a day. But mouse studies suggest that lower dosages of resveratrol might be more effective for longevity benefits. He will know this, so why 1 gram a day?

He also said that he doesn't take it on days he goes to the gym. Assuming he goes to the gym three days a week on Monday, Wednesday and Friday, this means he takes it 2 times between Monday and Friday, and on each day of the weekend. So he takes 1 gram four days a week.

Has this cycling got anything to do with his choice of dosage?

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stockcarman 17 Mar 2024

Sinclair will say one thing one day and another thing another day . Just watch some of his videos .

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osris 17 Mar 2024

Maybe, but he has not veered from his 1 gram a day protocol. Maybe 1 gram is best for human absorption.

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Galaxyshock 17 Mar 2024

So ChatGPT didn't provide answer to this one?

I don't really know who Mr. Sinclair is and what he takes, but I do assume he is not a mouse.

Personally I've stuck to low doses of Resveratrol, usually 100 mg and whatever I get from a few glasses of red wine.

Cycling works well for some substances, very true!

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osris 18 Mar 2024

I asked ChatGPT but it didn't know for sure. It said:

"David Sinclair, a renowned biologist and longevity researcher, indeed advocates for the use of resveratrol as a potential longevity-promoting supplement. His personal regimen of taking 1 gram of resveratrol per day may seem high compared to dosages suggested by some studies in mice. However, several factors may influence his dosage choice and cycling approach:

Individual Variation: Response to supplements can vary greatly among individuals. What works for one person may not work for another. Sinclair might have found through personal experimentation or observation that 1 gram per day works best for him.

Bioavailability: Resveratrol's bioavailability is a significant concern. The body metabolizes and eliminates it rapidly. Taking a higher dosage might be a strategy to ensure a sufficient amount reaches target tissues.

Human Studies: While mouse studies are valuable for initial insights, human studies provide more relevant data. Sinclair might be basing his dosage on human trials or anecdotal evidence rather than solely on mouse studies.

Personal Experience: Sinclair might have observed positive effects from this dosage in himself or others, which influences his recommendation.

Cycling Strategy: Cycling the supplement, such as skipping it on gym days, could be a strategic decision to avoid potential interactions or interference with exercise-induced signaling pathways. It might also be a way to manage potential tolerance or desensitization to the effects of resveratrol.

Longevity Goals: Sinclair's dosage and cycling strategy might be aligned with his specific longevity goals or theories, which could be based on his extensive research and understanding of aging processes.

Overall, while the dosage and cycling strategy may appear unconventional compared to some research findings, Sinclair likely has valid reasons based on his own research, experience, and observations. As with any supplement regimen, individual variations, personal goals, and responses should be considered."

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stockcarman 18 Mar 2024

I watched one of his videos where he said he took anywhere from 500mgs to a gram a day then another that he took a tablespoon a day without measuring .So who knows .

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