Do Antidepressants increase / alter lifesp...
accurate_atheist 21 Jul 2009
accurate_atheist 22 Jul 2009
If you've read some of the excellant works of Dr. Dilman, he clearly explains that increasing hypothalamic neurotransmitters to youthful levels can remove some effects of ageing. AD drugs and many psychedelics have an endocrinal impact. TCAs can increase melatonin synthesis (pineal grafts can even reverse menopause) Serotonin antagonists (Mianserin(Bolvidon), Mirtazapine(Remeron), aglometerine) have already shown to extend lives in worms. Chronic AD's reduce cortisol and this may increase lipespans. Lithium (and valproate and many anti-epileptics) and SSRI's and serotonin1A agonists (2A/2C antagonists) have robust neuroprotective and neurogenic effects, Lithium in particular inspite of a mood darkening "stabilising" effect; some people even take a low-dose Lithium. Of course Selegiline has undoubtable pro-longevity effects Phenytoin and Tianeptine(Stablon) reverse stress injury to the brain. There is no systematic study of AD's in life-extension, yet agents that increase lifespans are often antidepressive. So nature may want us to live "happy" ever after. I've wondered for long that we are overlooking AD's for LE. If you are optimistic do name some antidepressants that you think would lifespans, cite studies and being pragmatic name only AD's used or in trials to be used. Somewhat over-prescribed in cancer too, millions today have been taking ADs (antidepressants) for over a decade now!
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mwestbro 22 Jul 2009
accurate_atheist 22 Jul 2009
http://brainhealthha...your-life-span/
where they say that SSRI's are bad, serotonin antagonists fair better but it's equivocal. A lot of sites have come up this way, this one is not especially good though it's unfair to say I hate negatives just because I'm flesh and blood. However, wiki and a nature publication(+ve for Mianserin(31%) , Lithium(46%), Selegiline(25-40%) which no doubt increases catecholamines(Dr. Knoll's work) is rather trustworthy. Lithium low doses seem to be prophylactic in neurodegenerative diseases like Alzheimer's. Let's keep it going.
accurate_atheist 24 Jul 2009
another one favoing serotonin antagonists is this one http://www.plosone.o...al.pone.0004062
StrangeAeons 24 Jul 2009
accurate_atheist 25 Jul 2009
Psych 25 Jul 2009
Edited by Psych, 25 July 2009 - 03:38 PM.
StrangeAeons 25 Jul 2009
And secondly, what??? You're all over the place. To start a poll, just click the underlined sentence saying "Click here to manage this topic's poll options" when starting a thread. Only a navigator can do that to an already-started thread, AFAIK.
accurate_atheist 25 Jul 2009
What do we know about St. John's Wort, specifically hyperforin?
accurate_atheist 25 Jul 2009
StrangeAeons 25 Jul 2009
Try to formulate a point in your mind, state it, then substantiate it with technical details. I think there's some intelligence buried in your posts, but it looks more like coprolaila from a kid who was taught ligands instead of swear words. I'm not trying to be mean, it just makes you impossible to understand.
accurate_atheist 26 Jul 2009
AgeVivo 26 Jul 2009
You talk a lot about countering the aging hormonal changes; but i'm not sure this usually extends lifespan. Typically, if the effects of hormonal replacement therapies were clearly extending women's lifespans we would know it well. Same with human growth hormon.
You seem to talk about "pro-longevity" effects of some drugs; namely lithium and those:
are you referring to rodent studies? human studies? ThanksMetformin supposedly increases the sensitivity, we already know it's pro-long life. (...) Mirtazapine(Remeron) and the appetizer Cyproheptadine (Periactin) are strong 5HT-2C antagonists, suggesting a cause why they extend life in studies.
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tham 06 Aug 2009
http://brainhealthha...your-life-span/
http://www.plosone.o...al.pone.0004062