Datura seeds to upregulate aChR and 5-HT?
bog 11 Jan 2011
I was wondering if low dose of datura seeds, taken at the bedtime, would efficiently upregulate acetylcholine an serotonin receptors, since atropine, hyoscamine and scopolamine antagonize aChR and 5-HT.
It would work somelike as low doses of naltrexone.
This interrest me because datura is cheap and very easy to grow.
What is your opinion?
Thanks
kikai93 11 Jan 2011
Hello,
I was wondering if low dose of datura seeds, taken at the bedtime, would efficiently upregulate acetylcholine an serotonin receptors, since atropine, hyoscamine and scopolamine antagonize aChR and 5-HT.
It would work somelike as low doses of naltrexone.
This interrest me because datura is cheap and very easy to grow.
What is your opinion?
Thanks
It really wouldn't work that way at all, and could have cumulative toxic effects. Datura sucks, both from a clinical and subjective standpoint.
bog 11 Jan 2011
Doens't antagonists upregulate the receptors?
Which toxic effects?
^ risetolower v 11 Jan 2011
Edited by ^ risetolower v, 11 January 2011 - 09:12 PM.
maxwatt 12 Jan 2011
But it is an antidote to certain kinds of mushroom poisoning. ("One pill will make you larger, one pill will make you small....")That sh*t is poison.
treetop 12 Jan 2011
SayIDoAndIDont 12 Jan 2011
^ risetolower v 12 Jan 2011
kikai93 13 Jan 2011
But it is an antidote to certain kinds of mushroom poisoning. ("One pill will make you larger, one pill will make you small....")
From Psychopharmacologia: "All parts of Datura contain dangerous levels of poison and may be fatal if ingested by humans and other animals, including livestock and pets."
It's in the same toxicity class as Deadly Nightshade. There are better ways to achieve these goals, period.
Edited by kikai93, 13 January 2011 - 06:30 AM.
maxwatt 13 Jan 2011
I doubt that one seed would kill you, but there must be a better way to antagonize aChR and 5-HT.
bog 13 Jan 2011
One as cheap as datura ? Which is easily arable and which is in my placard ? I dont' think so.I doubt that one seed would kill you, but there must be a better way to antagonize aChR and 5-HT.
It can be so easily used without any poison effects.
To have regular effects alcohol extracts are very easy to make.
What's wrong with datura, you pussies.
Would antagonize receptors with datura cause their upregulation and procure a decent nootropic effects?
Thanks
kikai93 13 Jan 2011
One as cheap as datura ? Which is easily arable and which is in my placard ? I dont' think so.I doubt that one seed would kill you, but there must be a better way to antagonize aChR and 5-HT.
It can be so easily used without any poison effects.
To have regular effects alcohol extracts are very easy to make.
What's wrong with datura, you pussies.
Would antagonize receptors with datura cause their upregulation and procure a decent nootropic effects?
Thanks
Well first, calling people "pussies" isn't generally a great way to elicit their aid. As to what's wrong with Datura, let's go to Erowid. This is a website dedicated to providing real and pertinent information on a variety of psycho-active drugs, both legal and illegal. They will gleefully tell you all about a variety of psychoactives, how to dose them, what effects to expect, their legal status, how to produce them, the chemistry and pharmacology involved, etc. This is what they say about Datura:
As a general rule, Erowid neither recommends nor discourages the use of any psychoactive, however, in the case of tropane alkaloid-containing Solanaceae plants, we think it is important to note that an overwhelming majority of those who describe to us their use of Datura (and to a lesser extent, Belladonna, Brugmansia and Brunfelsia) find their experiences extremely mentally and physically unpleasant and not infrequently physically dangerous.
There is no way to guess a reasonable dose, because potency of the plant material itself and appropriate dose for an individual appear to vary so much. The question of what "reasonable" means for something that so often leads to such ridiculously negative effects is hard to say.
As an admixture plant in some traditional ayahuasca brews, smoking blends, or other preparations, parts of these plants are generally used in very low doses. Because of the serious adverse consequences associated with tropane alkaloids (scopolamine, atropine, hyoscyamine) intoxication and the wide variation in doses used, we are unwilling to even speculate about specific dosages for the leaves, flowers, and seeds of these plants.
If you are considering ingesting Datura-group plants, please read extensively from the collected experience reports and never take them without a reliable, sober sitter who understands the likely health issues and who can stop you from walking in front of traffic. Please note that fatalities from ingesting Datura do occur and hospitalizations seem to be quite common, in spite of the relatively low rates of psychoactive use of these plants.
These statements are all factual, and backed by clinical research, adverse incident reports, toxicology studies, anecdotal reports, etc. Tropane alkaloids are extremely dangerous. I recommend finding another solution.
The Human Meteorite 14 Jan 2011
One as cheap as datura ? Which is easily arable and which is in my placard ? I dont' think so.I doubt that one seed would kill you, but there must be a better way to antagonize aChR and 5-HT.
It can be so easily used without any poison effects.
To have regular effects alcohol extracts are very easy to make.
What's wrong with datura, you pussies.
Would antagonize receptors with datura cause their upregulation and procure a decent nootropic effects?
Thanks
Well first, calling people "pussies" isn't generally a great way to elicit their aid. As to what's wrong with Datura, let's go to Erowid. This is a website dedicated to providing real and pertinent information on a variety of psycho-active drugs, both legal and illegal. They will gleefully tell you all about a variety of psychoactives, how to dose them, what effects to expect, their legal status, how to produce them, the chemistry and pharmacology involved, etc. This is what they say about Datura:
As a general rule, Erowid neither recommends nor discourages the use of any psychoactive, however, in the case of tropane alkaloid-containing Solanaceae plants, we think it is important to note that an overwhelming majority of those who describe to us their use of Datura (and to a lesser extent, Belladonna, Brugmansia and Brunfelsia) find their experiences extremely mentally and physically unpleasant and not infrequently physically dangerous.
There is no way to guess a reasonable dose, because potency of the plant material itself and appropriate dose for an individual appear to vary so much. The question of what "reasonable" means for something that so often leads to such ridiculously negative effects is hard to say.
As an admixture plant in some traditional ayahuasca brews, smoking blends, or other preparations, parts of these plants are generally used in very low doses. Because of the serious adverse consequences associated with tropane alkaloids (scopolamine, atropine, hyoscyamine) intoxication and the wide variation in doses used, we are unwilling to even speculate about specific dosages for the leaves, flowers, and seeds of these plants.
If you are considering ingesting Datura-group plants, please read extensively from the collected experience reports and never take them without a reliable, sober sitter who understands the likely health issues and who can stop you from walking in front of traffic. Please note that fatalities from ingesting Datura do occur and hospitalizations seem to be quite common, in spite of the relatively low rates of psychoactive use of these plants.
These statements are all factual, and backed by clinical research, adverse incident reports, toxicology studies, anecdotal reports, etc. Tropane alkaloids are extremely dangerous. I recommend finding another solution.
Standardized extracts exist for a reason
kikai93 14 Jan 2011
Standardized extracts exist for a reason
Why take a risk this great? The OP is talking about growing his own plants and then (possibly) making extracts. He was originally talking about eating the seeds. I doubt he will get the effects he desires this way, and it's a risky proposition.
Thorsten3 14 Jan 2011
I know I am totally digressing here but it's a drug I would never take for recreational purposes, I admit I would be too afraid of such a thing. I think it is definitely one of the heavyweights when it comes to trips, not to mention blatantly dangerous if you OD by taking too much.. and how much is too much? Nah not for me thank you... Even if it was micro dosing for 'nootropic' purposes.. Although DMT on the other hand I am intrigued by (I have ayahuasca in my draw here, maybe I'll get around to trying it sometime). Not sure if you've heard of low dose ayahuasca, I think there a few die hards out there who apparantly reap the benefits of such a thing - obviously it isn't very relevant to the exact effects the OP is looking for acetylcholine - but there was a study which showed it upregulated 5HT quite a bit in those tribes who used it regularly.
Edited by Thorsten, 14 January 2011 - 12:53 PM.
srd 15 Jan 2011
bog 15 Jan 2011
This is a statement for recreational doses, which would be far away from nootropic dosage.One as cheap as datura ? Which is easily arable and which is in my placard ? I dont' think so.I doubt that one seed would kill you, but there must be a better way to antagonize aChR and 5-HT.
It can be so easily used without any poison effects.
To have regular effects alcohol extracts are very easy to make.
What's wrong with datura, you pussies.
Would antagonize receptors with datura cause their upregulation and procure a decent nootropic effects?
Thanks
Well first, calling people "pussies" isn't generally a great way to elicit their aid. As to what's wrong with Datura, let's go to Erowid. This is a website dedicated to providing real and pertinent information on a variety of psycho-active drugs, both legal and illegal. They will gleefully tell you all about a variety of psychoactives, how to dose them, what effects to expect, their legal status, how to produce them, the chemistry and pharmacology involved, etc. This is what they say about Datura:
As a general rule, Erowid neither recommends nor discourages the use of any psychoactive, however, in the case of tropane alkaloid-containing Solanaceae plants, we think it is important to note that an overwhelming majority of those who describe to us their use of Datura (and to a lesser extent, Belladonna, Brugmansia and Brunfelsia) find their experiences extremely mentally and physically unpleasant and not infrequently physically dangerous.
There is no way to guess a reasonable dose, because potency of the plant material itself and appropriate dose for an individual appear to vary so much. The question of what "reasonable" means for something that so often leads to such ridiculously negative effects is hard to say.
As an admixture plant in some traditional ayahuasca brews, smoking blends, or other preparations, parts of these plants are generally used in very low doses. Because of the serious adverse consequences associated with tropane alkaloids (scopolamine, atropine, hyoscyamine) intoxication and the wide variation in doses used, we are unwilling to even speculate about specific dosages for the leaves, flowers, and seeds of these plants.
If you are considering ingesting Datura-group plants, please read extensively from the collected experience reports and never take them without a reliable, sober sitter who understands the likely health issues and who can stop you from walking in front of traffic. Please note that fatalities from ingesting Datura do occur and hospitalizations seem to be quite common, in spite of the relatively low rates of psychoactive use of these plants.
These statements are all factual, and backed by clinical research, adverse incident reports, toxicology studies, anecdotal reports, etc. Tropane alkaloids are extremely dangerous. I recommend finding another solution.