TO ALL METHYLPHENIDATE NONRESPONDERS!...
srd
11 Feb 2011
HELLO ALL,
I am glad to share with you all how to make methylphenidate work. Tolerance to methylphenidate developes but it takes long time like 1-2 years. Those who lose its effects in days or weeks they are having this problem due to following.
Presynaptic dopamine D2 receptors acts as auto receptors. Whenever dopamine is released these receptors get stimulated and via negative feedback mechanism decrease dopamine release. As reserpine is able to block methylphenidate's effects due to depletion of vesicular dopamine depletion, In the same way d2 autoreceptor stimulation produces similar effects by decreasing dopamine synthesis. Methylphenidate is able to release only granular dopamine, it cannot release cytoplasmic dopamine like Amphetamines. So in those who have very sensitive D2 autoreceptors few doses of methylphenidate will decrease its effects greately. After that there will be very less dopamine in granules and if u take methylphenidate it will release it so condition of complete lack of dopamine will rise which is the reason many people feel drowsy, exausted and spaced out with methylphenidate
Adding low dose Buspirone Will solve this problem which acts as D2 autoreceptor antagonist and will increase dopamine synthesis. this combination worked great for me. Try it.
I am glad to share with you all how to make methylphenidate work. Tolerance to methylphenidate developes but it takes long time like 1-2 years. Those who lose its effects in days or weeks they are having this problem due to following.
Presynaptic dopamine D2 receptors acts as auto receptors. Whenever dopamine is released these receptors get stimulated and via negative feedback mechanism decrease dopamine release. As reserpine is able to block methylphenidate's effects due to depletion of vesicular dopamine depletion, In the same way d2 autoreceptor stimulation produces similar effects by decreasing dopamine synthesis. Methylphenidate is able to release only granular dopamine, it cannot release cytoplasmic dopamine like Amphetamines. So in those who have very sensitive D2 autoreceptors few doses of methylphenidate will decrease its effects greately. After that there will be very less dopamine in granules and if u take methylphenidate it will release it so condition of complete lack of dopamine will rise which is the reason many people feel drowsy, exausted and spaced out with methylphenidate
Adding low dose Buspirone Will solve this problem which acts as D2 autoreceptor antagonist and will increase dopamine synthesis. this combination worked great for me. Try it.
