Quatrefolic (new form of folate)
stephen_b 09 Jan 2012
http://www.quatrefol...Generation.html
http://www.quatrefol...nismAction.html
stephen_b 11 Jan 2012
is this better then regular methylfolate?
They make that claim:
Developed by Gnosis S.p.A, it represents the fourth generation folate providing greater stability, higher water solubility and multiple ingredient formulation flexibility compared to 5-methyltetrahydrofolate calcium salt guaranteeing an improved bioavailability.
Edited by stephen_b, 11 January 2012 - 03:54 PM.
pinnacle 31 Jul 2012
In this study you can see the 6[R]-isomer may not be so good.
Our results suggest that the 6[R] 5-MTHF isomer is stored in the body until it is released following the administration of a relatively large dosage of folic acid. Folates are stored in tissues, mainly in the liver where folates are bound tight by cytosolic and mitochondrial folate-binding proteins. This binding may not be stereospecific. The biological effects of 6[R] 5-MTHF binding are unclear. Mader et al. (1995) reported that no serious short-term side-effects were seen in patients receiving high doses of 6[R,S] 5-MTHF. Since 6[R] 5-MTHF is not metabolised, it can be speculated that it may inhibit regulatory enzymes related to folate and homocysteine metabolism. Secondly, the bioavailabity of 6[S] 5-MTHF may be reduced due to competition with the 6[R] 5-MTHF diastereoisomer.
http://www.ncbi.nlm....les/PMC1574248/
LEF's Optimized Folate looks promising.
Edited by pinnacle, 31 July 2012 - 01:06 PM.