Celastrus Paniculatus, experiences?
Reformed-Redan 18 Jan 2012
http://www.ncbi.nlm....pubmed/20645820The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and to mice (500 and 1500 mg/kg). The results were compared to piracetam (100 mg/kg, p.o.) used as a standard drug. Chemical hypoxia was induced by subcutaneous administration of sodium nitrite (35 mg/kg), immediately after acquisition training. In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. The estimation of acetylcholinesterase enzyme in rat brain supports the plus maze and passive avoidance test by reducing acetylcholinesterase activity which helps in memory performance. The study reveals that the aqueous extract of Celastrus paniculatus seed has dose-dependent cholinergic activity, thereby improving memory performance. The mechanism by which Celastrus paniculatus enhances cognition may be due to increased acetylcholine level in rat brain.
Looks nice. Note that the control was administered Piracetam. Any experiences with it? Might be a good Piracetam substitute.
Edited by redan, 18 January 2012 - 06:32 AM.
Ark 19 Jan 2012
Nootropic activity of Celastrus paniculatus seed. 2010 Mar;48(3):324-7
http://www.ncbi.nlm....pubmed/20645820The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and to mice (500 and 1500 mg/kg). The results were compared to piracetam (100 mg/kg, p.o.) used as a standard drug. Chemical hypoxia was induced by subcutaneous administration of sodium nitrite (35 mg/kg), immediately after acquisition training. In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. The estimation of acetylcholinesterase enzyme in rat brain supports the plus maze and passive avoidance test by reducing acetylcholinesterase activity which helps in memory performance. The study reveals that the aqueous extract of Celastrus paniculatus seed has dose-dependent cholinergic activity, thereby improving memory performance. The mechanism by which Celastrus paniculatus enhances cognition may be due to increased acetylcholine level in rat brain.
Looks nice. Note that the control was administered Piracetam. Any experiences with it? Might be a good Piracetam substitute.
Nice find, looks promising I haven't seen this in any supplements yet, have you?
LeonardElijah 19 Jan 2012
LeonardElijah 19 Jan 2012
Edited by LeonardElijah, 19 January 2012 - 08:48 PM.
MrSpud 20 Jan 2012
Reformed-Redan 20 Jan 2012
Omchiherbs.com sells it. Cognition soft gels. I bought some a few years back. It's ok, not super great tho
What's super-great? For me it feels somewhat like Oxiracetam with a longer half life. Not motivating; but, you feel it.
Edited by redan, 20 January 2012 - 06:53 AM.
Reformed-Redan 20 Jan 2012
http://www.sciencedi...378874104001254
Reformed-Redan 27 Jan 2012
Any dangers of prolonged use of AChE inhibitors?
Edited by redan, 27 January 2012 - 05:38 AM.
RAFT LIFE 16 Feb 2014
Edited by RAFT LIFE, 16 February 2014 - 07:06 PM.
Aka Poe 17 Apr 2015
Sorry to dig up an old thread. I have used Celastrus paniculatus over the years. At first we could only purchase the awful tasting oil and swallowed it with droppers, until the owner of Om-Chi herbs decided to encapsulate it in small caps like Vitamin D comes in, marketing it as Cognitol. I find it is effective at sharpening the mind, diminishes an alcohol hangover if taken the following morning after drinking, provides a mental energy to keep working on hard mental tasks. It is somewhat stimulating in my case, coupled with a slight increase in positive mood and helps keep me going at work. http://www.omchiherb...as/cognitol.htm
There are other Celastrus species such as P. orbicularis in the Far East, and also a North American variety which may deserve further study. Seeds from P. orbicularis that I collected, crushed and swallowed did not have similar effects as Om-Chi's Cognitol, so I did not pursue it further. Yes, kids do crazy things
I recall about 20 years ago, we first came across Celastus paniculatus when some fellow ethnobotanists were trying to obtain obscure Indian Ayrvedic cognitive enhancers, which at the time were relatively unknown in the west. These plants were primarily utilized traditonally in India for dementia. We came up with Schizandra berries, Turmeric, Gotu Kola, Ashwaganda, Bacopa, Androphagus and Celastrus paniculata as well as the seeds from three plants from the morning glory family; Convolvulus microphylus, Convolvulus pluricaulis and Evolvulus alsinoides. We obtained each of these, John Winslow of Om-Chi made extracts of them and we tested them on ourselves. John Winslow has been a leader of bringing forth lesser known plants from around the world and marketed some of them on his small family herb company in Oregon.
At the time we had little understanding of each plant's effects other than their known traditional usage for dementia, and I personally was seeking natural mental and physical energy enhancers so was disappointed that Bacopa was so sedative, made me feel sluggish, as did to a lesser degrees the morning glory plants, so gave up on them. I did stick with Schizandra (Schisandra), Ashwaganda and as mentioned, Celastrus once Om-Chi encapulated the foul tasting seed extract. I did not think to take the sedative Bacopa nor Morning Glory seeds extracts in the late evening for long term which might be the best protocol to avoid tiredness.
I think the Ayurvedic Indian morning glory plants may be helpful for people who seek a sedative in the evening to help with sleep and it may meanwhile help with long term cognitive function. Please note that none of these morning glory plants are hallucinogenic like some other varieties. It is possible they may have similar benefits as cognitive enhancers in a manner similar to other ergot derived medicines such as hydergine and bromocryptine and nicergoline. Seems further study is warranted.
A nice summary of some potential cognitive enhancing Ayurvedic herbs http://www.ncbi.nlm....les/PMC3506936/
Twice edited for spelling errors, I need cognitive help
Edited by Aka Poe, 17 April 2015 - 07:43 PM.
Flex 17 Apr 2015
I had a paste of those paniculatus seeds and the taste was awful: bitter with a sweet component ...
it didnt help me personally that much, I have to say that Cholinergics dont give me any enhancement in terms of intelligence or something like that.
It might be that I just dont notice any improvements.
All in one: Actually dissapionted but I do respond more to monoamine- or glutamergic stuff.
Edited by Flex, 17 April 2015 - 10:43 PM.
mait 18 Apr 2015
Similar experiences to Flex from my side. Made me sleepy as hell if taken at morning. Made me wake up after 3-4 hours of sleep if taken before bed. Only worked really really well if 2-3 hours of napping was possible after dosing after which superb clarity for hours was present. I have noticed similar "take substance, nap, get good effects" pattern with other cholinergic drugs such as Huperzine A, Shankhpushpi also. It may be theoretically interesting, but practically it is hindrance.
Flex 18 Apr 2015
Its nevertheless interresting. I didnt even know that this works.
I´m in the evening usually exhausted from Huperzine, when taken in the morning
but I´m also not able to sleep untill I become exhausted, so this could be problematic to reach it.
Btw: when I dont sleep the whole night and go to work, then is for me Huperzine one of the best supp for it.
normalizing 03 Feb 2016
how does huperzine benefit you? so would you suggest it as some type of replacement for caffeine based bevarages in the mornings?
gintrux 28 Jul 2020
It feels mentally warming seeing that someone also stumbled upon something this obscure and hidden 8 years ago on this forum. I just found this substance an ayurvedic herb book.
Pharmacological action- Oil is rubefacient; seeds are alterative, stimulant, and nervine tonic. Seeds and oil stimulate intellect and sharpen memory. 1 • 3 The seed oil produced sedation and anticonvulsant activity in rats and produced a gradual fall in blood pressure in cats. 260 Aerial parts of the plant indicated antiviral activity against Ranikhet disease virus. 11 An active fraction isolated from the oil by the countercurrent distribution method had a tranquilizing effect on rats, mice, monkeys, and cats.Z61 Medicinal properties and uses - Decoction of the seeds with or without the addition of some aromatics is recommended in rheumatism, gout, paralysis, and leprosy. Oil with benzoin, cloves, nutmeg, and mace is a sovereign remedy in beriberi and a powerful stimulant in doses of 10 to 15 minim. The leaves are emmenagogue, and the leaf sap is used as an antidote for opium poisoning. The bark is abortifacient, and the seeds are bitter, laxative, emetic, and tonic. Doses - Oil - 1 to 2 ml; powder -1 to 3 gr; decoction - 28 to 56 ml.
Could anyone share more experiences?
Edited by gintrux, 28 July 2020 - 10:13 AM.