Using ultrasound to move longevity drugs p...
treonsverdery
29 Feb 2012
There are a tremendous number of potentially beneficial treatments or optimizations scientists as well as physicians would like to pass the blood brain barrier.
I just read this pubmed reference that says ultrasound permits things to pass the blood brain barrier.
A typical, ultrasound imaging mode (pulsed wave [PW] Doppler) with specific settings (transmit frequency=5.7 MHz, gate size=15 mm, pulse repetition frequency=100 Hz, system power=15%) successfully opened the BBB, which facilitates implementation using the most of commercially available clinical diagnostic scanners. Localized opening of the BBB may have potential clinical utility for the delivery of diagnostic or therapeutic agents to the brain. http://www.ncbi.nlm....pubmed/19545939 a complimentary full text article
so from our perspective we might see if resveratrol (longevity), spermidine (longevity), EGF or VEGF (the twice as smart "doogie" mouse), or a methylating agent like S adenosyl methionine (prevents mouse alzheimers) all caused mice to live longer, gain cognitive ability, as well as retain all their cognitive function throughout their lifespan. Also microglia that live just at the CNS edit the developing as well as mature brain, thus reprogramming microglia with something like siRNA or peptides gives the capacity to completely change the areas that microglia, which are motile like leukocytes seek to repair or change.
Edited by treonsverdery, 29 February 2012 - 06:22 PM.
I just read this pubmed reference that says ultrasound permits things to pass the blood brain barrier.
A typical, ultrasound imaging mode (pulsed wave [PW] Doppler) with specific settings (transmit frequency=5.7 MHz, gate size=15 mm, pulse repetition frequency=100 Hz, system power=15%) successfully opened the BBB, which facilitates implementation using the most of commercially available clinical diagnostic scanners. Localized opening of the BBB may have potential clinical utility for the delivery of diagnostic or therapeutic agents to the brain. http://www.ncbi.nlm....pubmed/19545939 a complimentary full text article
so from our perspective we might see if resveratrol (longevity), spermidine (longevity), EGF or VEGF (the twice as smart "doogie" mouse), or a methylating agent like S adenosyl methionine (prevents mouse alzheimers) all caused mice to live longer, gain cognitive ability, as well as retain all their cognitive function throughout their lifespan. Also microglia that live just at the CNS edit the developing as well as mature brain, thus reprogramming microglia with something like siRNA or peptides gives the capacity to completely change the areas that microglia, which are motile like leukocytes seek to repair or change.
Edited by treonsverdery, 29 February 2012 - 06:22 PM.
