Resveratrol, Green Tea Extract, Curcumin,...
smithx 14 Aug 2012
http://www.ncbi.nlm....pubmed/22451473J Gerontol A Biol Sci Med Sci. 2012 Mar 26. [Epub ahead of print]
Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice.
Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE.
Source
Department of Pharmacology and Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, TX 78245. strong@uthscsa.edu.
Abstract
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only. PMID: 22451473 [PubMed - as supplied by publisher]
tunt01 14 Aug 2012
smithx 20 Aug 2012
joelcairo 21 Aug 2012
"They Did It Again: Overdosed Animals With Resveratrol And Then Said It Didn't Work"
http://www.resveratr...didnt-work/512/
joelcairo 21 Aug 2012
Edited by joelcairo, 21 August 2012 - 03:00 PM.
Kevnzworld 21 Aug 2012
Table 1 Medium Survival for each Intervention pooled across sites for each gender.
Group Males Females
Control 786 (742-826) 866 (832- 891)
Curcumin 808 (744-838) 905 (836-933)
Green Tea 822 (769-880) 923 (887-939 )
Oxaloacetic acid 819 (756-857) 889 (859-937)
Resveratrol 813 (763-863) 907 (871-938)
One quote from the study.
" Similarly, it was reported that male C57BL/6NNia mice, fed TC the primary blood metabolite of curcumin, at a concentration of 2000 ppm in diet starting at 13 months, had an 11.7% greater mean life span as compared with mice fed the control diet, "
In the female mice group fed resveratrol, all of the mice lived longer than the medium survival of the controls.
Which mouse would you choose to be, a supplemented or control? I think I'm going to continue taking my resveratrol, gte, and curcumin!
Edited by Kevnzworld, 21 August 2012 - 06:09 PM.
smithx 21 Aug 2012
algae 24 Aug 2012
Edited by algae, 24 August 2012 - 01:52 AM.
niner 24 Aug 2012
maxwatt 24 Aug 2012
Kevnzworld 26 Aug 2012
I happened upon an old post from years ago that highlighted a study that showed a cocktail of vitamins/supplements produced an 11% increase in LS in normal mice.
http://www.longecity...ements-in-mice/