LONGECITY

Hello very intelligent people, I've been lucky to find you

this is my first speech,
There is much talk about Mao inhibitors and COMT
but often the case that these enzymes have a low expression
and therefore neurotransmitters increase and saturation occurs

someone known natural inducers of these enzymes??

(sorry for my bad English)

Are you sure you don't mean inhibitors? Do you suffer from excess catecholamines? It seems most people would want to increase their dopamine, norepinephrine, etc

I think he means that people normally want to inhibit MAO and COMT but that he wants to enhance them. As for the actual question, no idea!

I do not seek inhibitors, I Seeking MAO and COMT inducers.
People who have high levels of catecholamines have serious problems such as obsessive compulsive disorder, ezquizofrenia, hyperactivity ... etc.
Drug treatment is performed with neuroleptics, but its action is detrimental.
I am a therapist, and I look natural inducers of MAO and COMT to reduce this excess catecholamines.
But so far I can not find any. I have found plants like Rauwolfia serpentina but they are hard to get

Thank you very much for your help

This is a very interesting topic! I'm sorry for my initial ignorance...

Have you considered Ibogaine? I believe it inhibits VMAT to some degree.

Not sure you got that entirely right, low serotonin is implicated in OCD (hence SSRIs) and low dopamine in ADHD (hence MPH and AMP, some even report decent results with a MAOB-I like Selegiline). Further lowering those through increasing MAO would seem like a rather bad idea to me.

HIGH Dopamine is thought to be one of the reasons for schizophrenia but I somehow doubt that boosting MAO would be a good idea in that case, either.
Edited by nupi, 23 December 2012 - 07:05 PM.

Hello Nupi: I have enough experience in this field, I have many documented cases with rigorous analytical and really, I'm in a position to guarantee what I say.
I recently published a book on ADHD (only in spain), "natural treatment of ADHD with biological medicine" and I can assure you that there are at least 20 dysfunctions of neurotransmitters that can cause this syndrome, and many other causes.
Upload a neurotransmitter levels is easy, there is a lot of information, supplements and drugs. But lowering them is a serious problem. I have treated autistic children with sertonina levels tripled, and doubled the maximum noradrenaline, and this is a serious problem.
I've had good results with orthomolecular medicine, but I'd find effective herbal catabolizadores act on. For some reason fail to remove.
Hello Peakplasma: thank you very much for your input, I do not know the product you're saying, but I will study.
The problem often lies in getting a lab who markets the plant.




Deshacer cambios

Ibogaine is actually quite popular; although, it is a controlled substance in the United States.

Here is a quote from the first link.

In an attempt to reconcile several conflicting findings, Staley et al., (167) proposed that ibogaine might promote redistribution of intraneuronal dopamine from vesicular to cytoplasmic pools. Ibogaine displays micromolar affinity for vesicular monoamine transporters labeled with [¹²⁵I]-tetrabenazine (167); these sites are crucial for the translocation of dopamine into synaptic vesicles. The inhibitory effect of ibogaine on vesicular monoamine transporters could result in redistribution of dopamine in the cytoplasm. Under such conditions, rapid metabolism of dopamine by monoamine oxidase would account for the decrease in tissue dopamine content and the parallel increase in its metabolites.

Your work has great potential to elucidate some of the mysterious/complex mechanisms at work.

I hope this helps!

any updates

Bump, because I'm also on the lookout for these.

 

Although I'll share that COMT is a methyltransferase, and could be boosted by raising availability of methyl donors (SAM, methylB12, methylB9, trimethylglycine...). The problem with that is that those (IIRC) are also involved with production of some of the same neurotransmitters, so what your end result will be is likely to vary based on your personal biochemistry. Which is why I'm still looking for outright COMT inducers.

Edited by Raza, 25 June 2015 - 09:25 AM.

Bump. Has anyone figured out anything constructive here?

I have a family member with very low functioning COMT due to several homozygous SNPs and female gender. She has a few mental illnesses. Anything potentially helpful? Thanks!

I do not seek inhibitors, I Seeking MAO and COMT inducers.
People who have high levels of catecholamines have serious problems such as obsessive compulsive disorder, ezquizofrenia, hyperactivity ... etc.
Drug treatment is performed with neuroleptics, but its action is detrimental.
I am a therapist, and I look natural inducers of MAO and COMT to reduce this excess catecholamines.
But so far I can not find any. I have found plants like Rauwolfia serpentina but they are hard to get

Thank you very much for your help

This is actually wrong. ocd is primarily not causes by catecholamines and if it ever is then it's very rarely. Hyperactivity is mostly a deficiency in catecholamines in specific parts of the brain. Stimulants tend to relax and focus people and not the opposite.

COMT

• "All flavonoids, except homoeriodictyol, enhanced COMT activity toward luteolin; genistein demonstrated the highest activity."
• Induction of catechol-O-methyltransferase in the luminal epithelium of rat uterus by progesterone.
• Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer.

MAO

• Chemotherapy-Induced Monoamine Oxidase Expression in Prostate Carcinoma Functions as a Cytoprotective Resistance Enzyme and Associates with Clinical Outcomes
• Calcium (Ca²⁺) has recently been shown to selectively increase the activity of monoamine oxidase-A (MAO-A), a mitochondria-bound enzyme that generates peroxyradicals as a natural by-product of the deamination of neurotransmitters such as serotonin. It has also been suggested that increased intracellular free Ca²⁺ levels as well as MAO-A may be contributing to the oxidative stress associated with Alzheimer disease (AD).
• Retinoic Acid Activates Monoamine Oxidase B Promoter in Human Neuronal Cells

 

I do not seek inhibitors, I Seeking MAO and COMT inducers.
People who have high levels of catecholamines have serious problems such as obsessive compulsive disorder, ezquizofrenia, hyperactivity ... etc.
Drug treatment is performed with neuroleptics, but its action is detrimental.
I am a therapist, and I look natural inducers of MAO and COMT to reduce this excess catecholamines.
But so far I can not find any. I have found plants like Rauwolfia serpentina but they are hard to get

Thank you very much for your help

This is actually wrong. ocd is primarily not causes by catecholamines and if it ever is then it's very rarely. Hyperactivity is mostly a deficiency in catecholamines in specific parts of the brain. Stimulants tend to relax and focus people and not the opposite.

 

 

i disagree. OCD is considered to be a subset of anxiety (just like panic attacks). stimulants make anxiety worse. stimulants only help focus and relax when one has too little catecholamines (depression, ADHD, too active MAOA or COMT). this is common sense and easy to check out when googling.

 

either way, the question was how to speed up MAOA or COMT. if you have anything constructive to say about it, i'm all ears.
 

I've been thinking about this very topic lately. It seems there's a number of reasons why high monoamine levels are bad.

First, and correct me if I'm wrong here, but sustained and long term levels of a given monoamine lead to post-synaptic downregulation. This post-synaptic down regulation may happen via the autoreceptors reacting to the high levels of monoamine release, due to the fact that there's a lot to release for any given stimuli. Or does it happen that post-synaptic receptors grow in numbers due to the large amount of monoamine activity, or presence of monoamines in vesicles "waiting in the wings," and so monoamine activity is enhanced for any given stimuli? In effect, it seems to me that high monoamines would lead to all the stereotypical symptoms of deficiency for a given monoamine, without there being a deficiency but in fact an excess.

The other potential problem I inagine is that we have little idea about what the actual monoamines do to brain tissue when present in large concentration over time. Does the immune system come into play and create inflammation in responce? Does the brain/immune system destroy neurons in responce, again creating a psuedo state of deficient-like symptoms?

Furthermore, how much does overmethylation play into this? Being able to produce neurotransmitters in great quantity might seem like a good thing, but not if you have defective or deficient MAO, COMT, or VMAT activity.

I have a feeling lots of people (and that includes real academics and neuroscientists) would look at the basic question of low activity of enzymes that break down monoamines and assume that couldn't be anything but a good thing. I also have searched, out of curiosity, to treatments for such a problem and haven't found much in the way of any MAO or COMT boosters.
Edited by Dichotohmy, 23 November 2016 - 06:15 AM.

Bump, this is an important topic. Niacin, nadh may help with comt by depleting excess methyl groups, no scientific research to back this up but seems to work for me a little bit.

Someone on another board claimed magnesium increases comt activity. I  have to look that up on punned.

Edited by iseethelight, 20 March 2017 - 12:23 AM.

I am a therapist, and I look natural inducers of MAO and COMT to reduce this excess catecholamines.
But so far I can not find any. I have found plants like Rauwolfia serpentina but they are hard to get

 

Don't know if this is an effective dose, but Himalaya carries Rauwolfia:

 

http://www.himalayaw...pina-tablet.htm
 

 

COMT

• "All flavonoids, except homoeriodictyol, enhanced COMT activity toward luteolin; genistein demonstrated the highest activity."
• Induction of catechol-O-methyltransferase in the luminal epithelium of rat uterus by progesterone.

 

Progesterone also increases MAO. I have high histamine from low MAO and this has been one of the few things that helped.