LONGECITY

So I've been taking TA-65 at a dose of 6 a day for nearly 3 months now and have noticed in the last few weeks an exponential growth of new moles on my skin. I hadn't noticed any new ones in many years now. Obviously, people can grow new ones will into their 40's, so this N=1 experiment can't have much merit, but it is very noticeable and seems to continue. I actually went to the dermatologist twice just to make sure they weren't cancerous. I don't particularly like moles, aesthetically speaking so in a way it's a bummer, but the article below suggests it at least has a possible up side and my experience may not be sheer coincidence.

Anyone else any experience with this?


http://www.examiner....d-to-age-slowly

"According to a 10-year study at the University of London King's College, people with more moles age at a slower rate. The study researched over 900 sets of twins and found that people with more than 100 moles on their body have an an average biological age of 6-7 years younger than people with less than 25 moles on their body. Biological age was estimated by researchers by using telomere length."

"To produce a visible mole from a signal cell requires about 30 cell doublings," explains Dr. William Andrews, CEO of Sierra Sciences, LLC. "People with shorter telomeres wouldn't be able to produce visible moles, while those with longer telomeres often have many moles."
With that being said, it should be no surprise that the study found that people with a lot of moles were found to have longer telomeres.
"I would go further than saying that those people with longer telomeres 'looked' up to seven years younger; I'd say that, biologically, they were up to seven years younger," says Dr. Andrews. "Because they have longer telomeres than average people, their 'clock of aging' runs a little longer than the average."

How intriguing!

How many new moles have you noticed?

Somewhere between 25-35....

Do you feel younger, more energetic, whatever since commencing the TA-65?

No. I feel as unhealthy as ever...

Dr Andrews has also said that younger adults shouldn't be affected by TA65 because their telomeres are already pretty long. I'm not sure how much he's tested that but when he displayed that 12-person non-random collection of measurements he did mention that the only 2 subjects that showed no telomere lengthening from TA65 were younger than the others. You'd probably learn more with a measurement.

Howard

Correct, but I've also spoken with Dr. Andrews and he said he believed young people would also benefit when I confronted him about that statement he made in the video presentation.

People with moles have longer telomeres? What a bunch of malarkey. I hate it when people take like ONE scientific study and read into it whatever they want, completely blowing it out of proportion and distorting it into junk science. For the sake of argument, let's say that people with moles have longer telomeres in their skin. When I say skin, I mean only SKIN. This means NOT speculating that other parts of the body also have long telomeres. Just the skin. So first off, moles do not appear in all skin types. They typically appear in people with more even "olive" skin tones who don't freckle easily and don't burn as easily. So already, these people have more built-in protection against UV damage from the sun. And yes, people with more protection against damaging sun radiation will probably have less cumulative damage to their telomeres and everything else in their skin. If you looked at the telomeres in skin cells of people with coal black skin, you'd probably find the same thing. This doesn't mean that they have a general golden ticket to the fountain of youth for their whole bodies. I don't think it's any great secret that people with more melanin in their skin have fewer wrinkles as they age. They may be more resistant to developing actual wrinkles, but their skin still sags the same. The fat pads that give our skin that youthful suppleness dissolve away the same in them as the rest of us.

People with moles have longer telomeres? What a bunch of malarkey. I hate it when people take like ONE scientific study and read into it whatever they want, completely blowing it out of proportion and distorting it into junk science. For the sake of argument, let's say that people with moles have longer telomeres in their skin. When I say skin, I mean only SKIN. This means NOT speculating that other parts of the body also have long telomeres. Just the skin. So first off, moles do not appear in all skin types. They typically appear in people with more even "olive" skin tones who don't freckle easily and don't burn as easily. So already, these people have more built-in protection against UV damage from the sun. And yes, people with more protection against damaging sun radiation will probably have less cumulative damage to their telomeres and everything else in their skin. If you looked at the telomeres in skin cells of people with coal black skin, you'd probably find the same thing. This doesn't mean that they have a general golden ticket to the fountain of youth for their whole bodies. I don't think it's any great secret that people with more melanin in their skin have fewer wrinkles as they age. They may be more resistant to developing actual wrinkles, but their skin still sags the same. The fat pads that give our skin that youthful suppleness dissolve away the same in them as the rest of us.

You sure got out of bed on the wrong side today. Take out your hate/frustration somewhere else please. Only a few possible inferences were made, nothing to get crazy about.

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For the sake of argument, let's say that people with moles have longer telomeres in their skin.
...

Here's what I think is the full-text of the study described in the news report:
http://cebp.aacrjour.../16/7/1499.full

It looks like the actual telomere measurements were for their while cells. Btw, all of the 2,786 subjects were Caucasian females so there is a built in bias.

Howard
Edited by hav, 23 August 2013 - 10:18 PM.

...
For the sake of argument, let's say that people with moles have longer telomeres in their skin.
...

Here's what I think is the full-text of the study described in the news report:
http://cebp.aacrjour.../16/7/1499.full

It looks like the actual telomere measurements were for their while cells. Btw, all of the 2,786 subjects were Caucasian females so there is a built in bias.

What's the bias? It appears that in Caucasian women, nevus count is highly correlated (p < 0.0001) with telomere length. And not just in skin.

What's the bias? It appears that in Caucasian women, nevus count is highly correlated (p < 0.0001) with telomere length. And not just in skin.

Maybe bias is the wrong word. I only mentioned it because it supports a critical post above in that none of the news articles I've seen mentioned the possible limitation of the conclusion applying only to caucasian women. But it could be there's a newer broader study by the same folks.

Howard
Edited by hav, 24 August 2013 - 02:46 PM.