LONGECITY

All:

See:

The Postponement of Aging by Aubrey de Grey
Developing Biomedical Tools to Repair Molecular and Cellular Damage by Aubrey de Grey

These are, to my knowledge, Aubrey's first written presentations of his vision for the use of mature nanotechnology in engineered negligible senescence (1-3). The ultimate use of it to repair (rather than obviate, as via WILT (4)) nuclear mutations is of particular interest.

Note: I have cross-posted this to the SENS subforum of Biotech:
http://www.imminst.o...t=0
... and it may be best to integrate discussion there.

-Michael

1. de Grey AD.
An engineer's approach to the development of real anti-aging medicine.
Sci Aging Knowledge Environ. 2003 Jan 8;2003(1):VP1. Review.
PMID: 12844502 [PubMed - indexed for MEDLINE]
http://www.gen.cam.a...ens/focusPP.pdf

2. de Grey AD.
Challenging but essential targets for genuine anti-ageing drugs.
Expert Opin Ther Targets. 2003 Feb;7(1):1-5. PMID: 12556198 [PubMed - as supplied by publisher]
http://www.gen.cam.a...sens/manu21.pdf

3. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJ, Stock G.
Time to talk SENS: critiquing the immutability of human aging.
Ann N Y Acad Sci. 2002 Apr;959:452-62; discussion 463-5.
PMID: 11976218 [PubMed - indexed for MEDLINE]
http://www.gen.cam.a...sens/manu12.pdf

4. de Grey AD, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CA, Porterg AC.
Total deletion of in vivo telomere elongation capacity: an ambitious but
possibly ultimate cure for all age-related human cancers.
Ann N Y Acad Sci. 2004 Jun;1019:147-70. Review.
PMID: 15247008 [PubMed - indexed for MEDLINE]
http://www.gen.cam.ac.uk/sens/WILT.pdf

Could we hope to have a personal area network of nanobots that could rebuild us in the case of a car accident?

It would be good to see the end of the WILT anachronism and something nDNA repairish to replace it..

I think nanotechnology, as a concept, is most useful for defining the limits of what is theoretically possible. How things are actually done as a practical matter-- cures for cancer, treatments for aging, etc. --will be quite different from in-situ nanomachines for a long time to come. But as a concept, nanotechnology is extremely powerful. For instance, even if the SENS approach (or any other specific approach) for the treatment of aging were to be debunked or found impractical, we still know that aging is fundamentally reversible by virtue of the fact that we are made of atoms and molecules, and atoms and molecules can in principle be manipulated in general ways. By the same reasoning, we know that WILT is fundamentally unnecessary for treatment of cancer or aging. It is purely a stop-gap measure, and may never be implemented in practice before being leap-frogged by other technologies that achieve the same objectives less invasively.

Should we use centric AGI or swarms to control the nanobots?
Edited by caston, 09 July 2006 - 03:22 PM.